Gold Nanocages for Biomedical Applications

Nanostructured materials provide a promising platform for early cancer detection and treatment. Here we highlight recent advances in the synthesis and use of Au nanocages for such biomedical applications. Gold nanocages represent a novel class of nanostructures, which can be prepared via a remarkably simple route based on the galvanic replacement reaction between Ag nanocubes and HAuCl(4). The Au nanocages have a tunable surface plasmon resonance peak that extends into the near-infrared, where the optical attenuation caused by blood and soft tissue is essentially negligible. They are also biocompatible and present a well-established surface for easy functionalization. We have tailored the scattering and absorption cross-sections of Au nanocages for use in optical coherence tomography and photothermal treatment, respectively. Our preliminary studies show greatly improved spectroscopic image contrast for tissue phantoms containing Au nanocages. Our most recent results also demonstrate the photothermal destruction of breast cancer cells in vitro by using immuno-targeted Au nanocages as an effective photo-thermal transducer. These experiments suggest that Au nanocages may be a new class of nanometer-sized agents for cancer diagnosis and therapy.

[1]  Meyer H. Birnboim,et al.  Composite structures for the enhancement of nonlinear-optical susceptibility , 1989 .

[2]  Younan Xia,et al.  Shape-Controlled Synthesis of Gold and Silver Nanoparticles , 2002, Science.

[3]  F. Fiévet,et al.  Preparing Monodisperse Metal Powders in Micrometer and Submicrometer Sizes by the Polyol Process , 1989 .

[4]  M. Faraday X. The Bakerian Lecture. —Experimental relations of gold (and other metals) to light , 1857, Philosophical Transactions of the Royal Society of London.

[5]  Younan Xia,et al.  Mechanistic studies on the galvanic replacement reaction between multiply twinned particles of Ag and HAuCl4 in an organic medium. , 2007, Journal of the American Chemical Society.

[6]  Younan Xia,et al.  Multiple‐Walled Nanotubes Made of Metals , 2004 .

[7]  E. Coronado,et al.  The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment , 2003 .

[8]  R. Murray,et al.  Monolayer-protected cluster molecules. , 2000, Accounts of chemical research.

[9]  Younan Xia,et al.  Template-Engaged Replacement Reaction: A One-Step Approach to the Large-Scale Synthesis of Metal Nanostructures with Hollow Interiors , 2002 .

[10]  S. L. Westcott,et al.  Infrared extinction properties of gold nanoshells , 1999 .

[11]  Paul Mulvaney,et al.  Synthesis of Nanosized Gold−Silica Core−Shell Particles , 1996 .

[12]  M. El-Sayed,et al.  Spectral Properties and Relaxation Dynamics of Surface Plasmon Electronic Oscillations in Gold and Silver Nanodots and Nanorods , 1999 .

[13]  C. E. Moran,et al.  Reduced symmetry metallodielectric nanoparticles: Chemical synthesis and plasmonic properties , 2003 .

[14]  U. Kreibig,et al.  Optical properties of aggregates of small metal particles , 1986 .

[15]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[16]  Joseph M. McLellan,et al.  Facile synthesis of gold-silver nanocages with controllable pores on the surface. , 2006, Journal of the American Chemical Society.

[17]  Younan Xia,et al.  Mechanistic study on the replacement reaction between silver nanostructures and chloroauric acid in aqueous medium. , 2004, Journal of the American Chemical Society.

[18]  Naomi J Halas,et al.  Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. , 2003, Annual review of biomedical engineering.

[19]  C. Schönenberger,et al.  Aqueous Gold Sols of Rod-Shaped Particles , 1997 .

[20]  Michele Follen,et al.  Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. , 2003, Cancer research.

[21]  Younan Xia,et al.  Gold Nanocages: Engineering Their Structure for Biomedical Applications , 2005 .

[22]  Younan Xia,et al.  Polyol Synthesis of Uniform Silver Nanowires: A Plausible Growth Mechanism and the Supporting Evidence , 2003 .

[23]  Hui Zhang,et al.  Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. , 2005, Nano letters.

[24]  Leon Hirsch,et al.  Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer , 2004, Technology in cancer research & treatment.

[25]  Naomi J. Halas,et al.  Plasmon Resonance Shifts of Au-Coated Au 2 S Nanoshells: Insight into Multicomponent Nanoparticle Growth , 1997 .

[26]  D. Feldheim,et al.  Assembly of Phenylacetylene-Bridged Silver and Gold Nanoparticle Arrays , 2000 .

[27]  Joseph M. McLellan,et al.  Rapid synthesis of small silver nanocubes by mediating polyol reduction with a trace amount of sodium sulfide or sodium hydrosulfide. , 2006, Chemical physics letters.

[28]  Cheng-Dah Chen,et al.  The Shape Transition of Gold Nanorods , 1999 .

[29]  Younan Xia,et al.  Increased sensitivity of surface plasmon resonance of gold nanoshells compared to that of gold solid colloids in response to environmental changes. , 2002, Analytical chemistry.

[30]  Joseph M. McLellan,et al.  Fabrication of cubic nanocages and nanoframes by dealloying Au/Ag alloy nanoboxes with an aqueous etchant based on Fe(NO3)3 or NH4OH. , 2007, Nano letters.

[31]  J. Fujimoto Optical coherence tomography for ultrahigh resolution in vivo imaging , 2003, Nature Biotechnology.

[32]  M. El-Sayed,et al.  Some interesting properties of metals confined in time and nanometer space of different shapes. , 2001, Accounts of chemical research.

[33]  Younan Xia,et al.  Alloying and Dealloying Processes Involved in the Preparation of Metal Nanoshells through a Galvanic Replacement Reaction , 2003 .

[34]  Hongwei Liao,et al.  Biomedical applications of plasmon resonant metal nanoparticles. , 2006, Nanomedicine.

[35]  Naomi J. Halas,et al.  Linear optical properties of gold nanoshells , 1999 .

[36]  Younan Xia,et al.  Shape-controlled synthesis of metal nanostructures: the case of silver. , 2005, Chemistry.

[37]  Xingde Li,et al.  Shape-Controlled Synthesis of Silver and Gold Nanostructures , 2005 .

[38]  Yi Lu,et al.  A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles. , 2003, Journal of the American Chemical Society.

[39]  Catherine J. Murphy,et al.  CONTROLLING THE ASPECT RATIO OF INORGANIC NANORODS AND NANOWIRES , 2002 .

[40]  C. R. Chris Wang,et al.  Gold Nanorods: Electrochemical Synthesis and Optical Properties , 1997 .

[41]  G. Whitesides,et al.  Unconventional Methods for Fabricating and Patterning Nanostructures. , 1999, Chemical reviews.

[42]  Younan Xia,et al.  Polyol Synthesis of Silver Nanoparticles: Use of Chloride and Oxygen to Promote the Formation of Single-Crystal, Truncated Cubes and Tetrahedrons , 2004 .

[43]  M. Abrams,et al.  Metal compounds in therapy and diagnosis. , 1993, Science.

[44]  Michael Vollmer,et al.  Optical properties of metal clusters , 1995 .

[45]  B A Huberman,et al.  Cooperative Solution of Constraint Satisfaction Problems , 1991, Science.

[46]  Younan Xia,et al.  Gold nanostructures: engineering their plasmonic properties for biomedical applications. , 2006, Chemical Society reviews.

[47]  Jae Hee Song,et al.  Photochemical synthesis of gold nanorods. , 2002, Journal of the American Chemical Society.

[48]  Naomi J. Halas,et al.  Nanoengineering of optical resonances , 1998 .

[49]  Naomi J. Halas,et al.  GENERAL VECTOR BASIS FUNCTION SOLUTION OF MAXWELL'S EQUATIONS , 1997 .

[50]  K. Suslick,et al.  Engineered microsphere contrast agents for optical coherence tomography. , 2003, Optics letters.

[51]  Younan Xia,et al.  Gold nanocages as contrast agents for spectroscopic optical coherence tomography. , 2005, Optics letters.

[52]  Younan Xia,et al.  Metal Nanostructures with Hollow Interiors , 2003 .

[53]  Younan Xia,et al.  Large-scale synthesis of silver nanocubes: the role of HCl in promoting cube perfection and monodispersity. , 2005, Angewandte Chemie.

[54]  J. Creighton,et al.  Plasma resonance — enhanced raman scattering by absorbates on gold colloids: The effects of aggregation , 1982 .

[55]  Milton Kerker,et al.  Scattering of Electromagnetic Waves from Two Concentric Spheres , 1951 .

[56]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[57]  R.R. Anderson,et al.  Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. , 1983, Science.

[58]  Alfons van Blaaderen,et al.  Metallodielectric Colloidal Core−Shell Particles for Photonic Applications , 2002 .

[59]  Charles R. Martin,et al.  Template Synthesized Nanoscopic Gold Particles: Optical Spectra and the Effects of Particle Size and Shape , 1994 .

[60]  J. Fujimoto,et al.  Spectroscopic optical coherence tomography. , 2000 .

[61]  Igor L. Medintz,et al.  Quantum dot bioconjugates for imaging, labelling and sensing , 2005, Nature materials.

[62]  U. Kreibig,et al.  OPTICAL ABSORPTION OF SMALL METALLIC PARTICLES , 1985 .