Genetics and cytogenetics of retinoblastoma.

[1]  A. Hogg,et al.  Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing. , 1992, Oncogene.

[2]  A. Hogg,et al.  Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Cowell,et al.  Follow-up of retinoblastoma patients having prenatal and perinatal predictions for mutant gene carrier status using intragenic polymorphic probes from the RB1 gene. , 1992, British Journal of Cancer.

[4]  B. Gallie,et al.  Failure of RB1 to reverse the malignant phenotype of human tumor cell lines. , 1992, Cancer research.

[5]  M. Ewen,et al.  The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner , 1992, Cell.

[6]  L. Tsai,et al.  Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F , 1992, Nature.

[7]  M. Ewen,et al.  Interaction between human cyclin A and adenovirus E1A-associated p107 protein. , 1992, Science.

[8]  W. Lee,et al.  Intraocular tumor suppression of retinoblastoma gene-reconstituted retinoblastoma cells. , 1991, Cancer research.

[9]  M. Knowles,et al.  Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma. , 1991, Oncogene.

[10]  A. Condie,et al.  A familial RB1 mutation detected by the HOT technique is homozygous in a second primary neoplasm. , 1991, Oncogene.

[11]  N. L. La Thangue,et al.  A developmentally regulated and tissue‐dependent transcription factor complexes with the retinoblastoma gene product. , 1991, The EMBO journal.

[12]  Y. Qian,et al.  The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle , 1991, Cell.

[13]  S. Maeda,et al.  Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. , 1991, Cancer research.

[14]  S. Hirohashi,et al.  Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. , 1991, Cancer research.

[15]  Patricia L. Blount,et al.  Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. , 1991, Cancer research.

[16]  M. Ewen,et al.  Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein , 1991, Cell.

[17]  T. Hunter,et al.  Cyclins and cancer , 1991, Cell.

[18]  T. L. McGee,et al.  Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene , 1991, Nature.

[19]  G. Klein,et al.  Intraocular tumor formation of RB reconstituted retinoblastoma cells. , 1991, Cancer research.

[20]  A. Rustgi,et al.  Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product , 1991, Nature.

[21]  M. Belvin,et al.  Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. , 1991, Oncogene.

[22]  Pearl S Huang,et al.  Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product , 1991, Nature.

[23]  T. Hunt,et al.  Cyclin A and the retinoblastoma gene product complex with a common transcription factor , 1991, Nature.

[24]  J. Nevins,et al.  Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A , 1991, Cell.

[25]  W. Kaelin,et al.  The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein , 1991, Cell.

[26]  Joseph R. Nevins,et al.  The E2F transcription factor is a cellular target for the RB protein , 1991, Cell.

[27]  R. Weinmann,et al.  The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F , 1991, Cell.

[28]  N. L. Thangue,et al.  Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor , 1991, Nature.

[29]  V. Blanquet,et al.  Physical map around the retinoblastoma gene: possible genomic imprinting suggested by NruI digestion. , 1991, Genomics.

[30]  R. Weinberg,et al.  G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment , 1991, Cell.

[31]  J. Cowell,et al.  Application of PCR amplification of DNA from paraffin embedded tissue sections to linkage analysis in familial retinoblastoma. , 1991, Journal of medical genetics.

[32]  B. Horsthemke,et al.  Characterization of deletions at the retinoblastoma locus in patients with bilateral retinoblastoma. , 1991, American journal of medical genetics.

[33]  W. Gullick,et al.  Inactivation of the retinoblastoma gene does not lead to loss of TGF-beta receptors or response to TGF-beta in breast cancer cell lines. , 1991, Oncogene.

[34]  M. Sporn,et al.  Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[35]  W. Benedict,et al.  Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression. , 1991, Oncogene.

[36]  W. Lee,et al.  Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. , 1991, The EMBO journal.

[37]  J. Cowell,et al.  Genetic counselling in retinoblastoma: importance of ocular fundus examination of first degree relatives and linkage analysis. , 1991, The British journal of ophthalmology.

[38]  F. Kaye,et al.  Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product , 1991, Cell.

[39]  K. Redmond,et al.  Clinical presentation, treatment, and outcome of trilateral retinoblastoma , 1991, Cancer.

[40]  A. Okamoto,et al.  Variable mutations of the RB gene in small-cell lung carcinoma. , 1990, Oncogene.

[41]  W. Lee,et al.  Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[42]  P. Robbins,et al.  Negative regulation of human c-fos expression by thes retinoblastoma gene product , 1990, Nature.

[43]  J. Massagué,et al.  Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation , 1990, Cell.

[44]  M. Jay,et al.  Application of intragenic DNA probes in prenatal screening for retinoblastoma gene carriers in the United Kingdom. , 1990, Archives of disease in childhood.

[45]  M. Ewen,et al.  Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product , 1990, Molecular and cellular biology.

[46]  W. Lee,et al.  Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. , 1990, The EMBO journal.

[47]  S. Naylor,et al.  Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. , 1990, Cancer research.

[48]  G. Klein,et al.  Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[49]  N. Dyson,et al.  The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. , 1990, The EMBO journal.

[50]  R. Weinberg,et al.  Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[51]  W. Lee,et al.  PCR-based detection of a polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) gene. , 1990, Nucleic acids research.

[52]  W. Lee,et al.  Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. , 1990, Science.

[53]  J M Trent,et al.  Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6. , 1990, Science.

[54]  B. Gallie,et al.  A physical map around the retinoblastoma gene. , 1990, Genomics.

[55]  B. Gallie,et al.  Use of the RB1 cDNA as a diagnostic probe in retinoblastoma families , 1990, Clinical genetics.

[56]  G. S. Cowley,et al.  Detection of the XbaI RFLP within the retinoblastoma locus by PCR , 1990, Nucleic Acids Res..

[57]  E. Buckley,et al.  Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. , 1989, The New England journal of medicine.

[58]  B. Gallie,et al.  Mutations in the RB1 gene and their effects on transcription , 1989, Molecular and cellular biology.

[59]  T. Sekiya,et al.  Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. , 1989, Genomics.

[60]  P. Grabham,et al.  The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells. , 1989, Oncogene.

[61]  H. Tien,et al.  Cytogenetic evidence of multifocal origin of a unilateral retinoblastoma. A help in genetic counseling. , 1989, Cancer genetics and cytogenetics.

[62]  T. Dryja,et al.  Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing. , 1989, American journal of human genetics.

[63]  David M. Livingston,et al.  The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element , 1989, Cell.

[64]  E. Harlow,et al.  The retinoblastoma protein is phosphorylated during specific phases of the cell cycle , 1989, Cell.

[65]  Phang-lang Chen,et al.  Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation , 1989, Cell.

[66]  G. Draper,et al.  Non-ocular cancer in relatives of retinoblastoma patients. , 1989, British Journal of Cancer.

[67]  K. Tan,et al.  Linkage analysis of families with hereditary retinoblastoma: nonpenetrance of mutation, revealed by combined use of markers within and flanking the RB1 gene. , 1989, American journal of human genetics.

[68]  T. L. McGee,et al.  Structure and partial genomic sequence of the human retinoblastoma susceptibility gene. , 1989, Gene.

[69]  A. Goddard,et al.  Preferential germline mutation of the paternal allele in retinoblastoma , 1989, Nature.

[70]  Lee Wh,et al.  Studies of the retinoblastoma gene in human sarcomas. , 1989 .

[71]  W. Lee,et al.  Structure of the human retinoblastoma gene. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[72]  T. Dryja,et al.  Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[73]  T. Dryja,et al.  Parental origin of mutations of the retinoblastoma gene , 1989, Nature.

[74]  W. J. Brammar,et al.  The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. , 1989, Oncogene.

[75]  R. Weinberg,et al.  Point mutational inactivation of the retinoblastoma antioncogene. , 1989, Science.

[76]  K. Münger,et al.  The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. , 1989, Science.

[77]  E. Harlow,et al.  Cellular targets for transformation by the adenovirus E1A proteins , 1989, Cell.

[78]  Chun-Ming Huang,et al.  SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family , 1989, Cell.

[79]  W. Cavenee,et al.  Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus , 1989, Molecular and cellular biology.

[80]  P. L. Chen,et al.  Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. , 1988, Science.

[81]  B. Gallie,et al.  Identification of germline and somatic mutations affecting the retinoblastoma gene. , 1988, Science.

[82]  J. Minna,et al.  Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. , 1988, Science.

[83]  Wen-Hwa Lee,et al.  SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene , 1988, Cell.

[84]  K. Ishizaki,et al.  Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. , 1988, Cancer research.

[85]  Stephen H. Friend,et al.  Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product , 1988, Nature.

[86]  W. Lee,et al.  Inactivation of the retinoblastoma susceptibility gene in human breast cancers. , 1988, Science.

[87]  D. Brunoni,et al.  Bilateral retinoblastoma associated with 13q-mosaicism. Possible manifestation of a germinal mutation. , 1988, Cancer genetics and cytogenetics.

[88]  B. Gallie,et al.  Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors , 1988, Molecular and cellular biology.

[89]  K. Nicolaides,et al.  PRENATAL EXCLUSION OF HEREDITARY RETINOBLASTOMA , 1988, The Lancet.

[90]  A. Craft,et al.  Prediction of the risk of hereditary retinoblastoma, using DNA polymorphisms within the retinoblastoma gene. , 1988, The New England journal of medicine.

[91]  R. Weinberg,et al.  Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[92]  J. Opitz,et al.  Deletion (13) (q14.1q14.3) in two generations: Variability of ocular manifestations and definition of the phenotype , 1987 .

[93]  Wen-Hwa Lee,et al.  The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity , 1987, Nature.

[94]  M. Jay,et al.  A chromosomal breakpoint that separates the esterase D and retinoblastoma predisposition loci in a patient with del(13)(q14q31). , 1987, Cancer genetics and cytogenetics.

[95]  S. Hinrichs,et al.  Structural evidence for the authenticity of the human retinoblastoma gene. , 1987, Science.

[96]  M. Jay,et al.  An assessment of the usefulness of electrophoretic variants of esterase-D in the antenatal diagnosis of retinoblastoma in the United Kingdom. , 1987, British Journal of Cancer.

[97]  W. Lee,et al.  Human retinoblastoma susceptibility gene: cloning, identification, and sequence , 1987, Science.

[98]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[99]  T. Dryja,et al.  Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[100]  B. Gallie,et al.  Tumour induction by the retinoblastoma mutation is independent of N-myc expression , 1986, Nature.

[101]  R. Ellsworth,et al.  Chromosomal abnormalities in human retinoblastoma a review , 1986, Cancer.

[102]  J. Kingston,et al.  Second primary neoplasms in patients with retinoblastoma. , 1986, British Journal of Cancer.

[103]  Keith Cg,et al.  Retinoblastoma and Retinoma Occurring in a Child With a Translocation and Deletion of the Long Arm of Chromosome 13 , 1985 .

[104]  S. Latt,et al.  Molecular and cytologic analysis of DNA amplification in retinoblastoma. , 1985, Cancer genetics and cytogenetics.

[105]  B. Gallie,et al.  Genetic origin of mutations predisposing to retinoblastoma. , 1985, Science.

[106]  C. Junien,et al.  Cytogenetic forms of retinoblastoma: their incidence in a survey of 66 patients. , 1985, Cancer genetics and cytogenetics.

[107]  A. Knudson Hereditary cancer, oncogenes, and antioncogenes. , 1985, Cancer research.

[108]  Wen-Hwa Lee,et al.  Expression and amplification of the N-myc gene in primary retinoblastoma , 1984, Nature.

[109]  S. Latt,et al.  Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus. , 1984, Cancer genetics and cytogenetics.

[110]  Raymond L. White,et al.  Homozygosity of chromosome 13 in retinoblastoma. , 1984, The New England journal of medicine.

[111]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.

[112]  B. Gallie,et al.  Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma , 1983, Nature.

[113]  A. Sandberg,et al.  Chromosome 6 in malignant melanoma. , 1983, Cancer genetics and cytogenetics.

[114]  W. Benedict,et al.  Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. , 1983, Science.

[115]  M. Sasaki,et al.  Possible inactivation of part of chromosome 13 due to 13qXp translocation associated with retinoblastoma , 1982, Clinical genetics.

[116]  B. Gallie,et al.  Retinoma: spontaneous regression of retinoblastoma or benign manifestation of the mutation? , 1982, British Journal of Cancer.

[117]  L. Rorke,et al.  Bilateral retinoblastoma with ectopic intracranial retinoblastoma: trilateral retinoblastoma. , 1982, Cancer genetics and cytogenetics.

[118]  L. Strong,et al.  Familial retinoblastoma and chromosome 13 deletion transmitted via an insertional translocation. , 1981, Science.

[119]  W. Benedict,et al.  Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14. , 1980, Science.

[120]  T. Hida,et al.  Bilateral retinoblastoma with a 13qXp translocation. , 1980, Journal of pediatric ophthalmology and strabismus.

[121]  W. W. Nichols,et al.  Further observations on a 13qXp translocation associated with retinoblastoma. , 1980, American journal of ophthalmology.

[122]  U. Francke,et al.  Partial triplication and deletion of 13q: study of a family presenting with bilateral retinoblastomas , 1979, Clinical genetics.

[123]  J. Yunis,et al.  Retinoblastoma and subband deletion of chromosome 13. , 1978, American journal of diseases of children.

[124]  R. Ellsworth,et al.  Pleiotropic effects of the gene for retinoblastoma , 1974, Journal of medical genetics.

[125]  A. Knudson Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[126]  A. Sorsby,et al.  THE GENETICS OF RETINOBLASTOMA* , 1944, The British journal of ophthalmology.

[127]  R. Takahashi,et al.  Genomic organization of the human retinoblastoma gene. , 1989, Oncogene.

[128]  J. Cowell,et al.  Predisposition to retinoblastoma due to a translocation within the 4.7R locus. , 1989, Oncogene.

[129]  J. Nevins Mechanisms of viral-mediated trans-activation of transcription. , 1989, Advances in virus research.

[130]  M. Jay,et al.  Genetic and cytogenetic analysis of patients showing reduced esterase-D levels and mental retardation from a survey of 500 individuals with retinoblastoma. , 1989, Ophthalmic paediatrics and genetics.

[131]  B. Horsthemke,et al.  Mechanism of i(6p) formation in retinoblastoma tumor cells. , 1989, Cancer genetics and cytogenetics.

[132]  J. Yokota,et al.  Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. , 1988, Oncogene.

[133]  F. Mitelman,et al.  Amplification of the human putative oncogene INT1 in primary retinoblastoma tumors. , 1988, Cytogenetics and cell genetics.

[134]  B. Gallie,et al.  Re-evaluation of the sublocalization of esterase D and its relation to the retinoblastoma locus by in situ hybridization. , 1987, Cytogenetics and cell genetics.

[135]  R. Ellsworth,et al.  Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? , 1984, Ophthalmology.

[136]  A. Leblanc,et al.  Two cases of del(13q)-retinoblastoma and two cases of partial trisomy due to a familial insertion. , 1983, Annales de genetique.

[137]  J. Cowell,et al.  Double minutes and homogeneously staining regions: gene amplification in mammalian cells. , 1982, Annual review of genetics.

[138]  H. Stallard The conservative treatment of retinoblastoma. , 1962, Transactions of the ophthalmological societies of the United Kingdom.