Microwave-Assisted Rhodium-Complex-Catalyzed Cascade Decarbonylation and Asymmetric Pauson–Khand-Type Cycli­zations

Microwave-assisted Rh–diphosphane-complex-catalyzed dual catalysis is reported. This cooperative process provides [2+2+1] cycloadducts by sequential decarbonylation of aldehyde or formate and carbonylation of enynes within a short period of time. Various O-, N-, and C-tethered enynes were transformed into the corresponding products in good yields. The first enantioselective version of this microwave-accelerated cascade cyclization was realized. In the presence of chiral Rh-(S)-bisbenzodioxanPhos complex, the cyclopentenone products were achieved with ee values up to 90 %. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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