Measuring health status and quality of life in HIV and AIDS

Abstract HIV can diminish quality of life profoundly, and it is important to understand and measure such effects of HIV and its treatments Although the term quality of life is commonly used, “health status” more accurately describes dimensions that are directly health related and that may be affected by traditional interventions. There is a substantial literature on general health status measurement, and several of the most established measures have been applied or adapted for use in HIV infected populations These measures include the Medical Outcomes Study health ratings, the Quality of Well-Being scale, and the Sickness Impact Profile. Cancer-specific measures such as the EORTC Quality of Life Core Questionnaire and the CARES have also been adapted. In the last three years, health status measures for HIV have been completed by several thousand patients, and have generally proved to be reliable and valid indicators of relevant clinical differences such as disease stage, numbers of symptoms, and other psy...

[1]  J. Morrow,et al.  Quality of life of hospitalized persons with AIDS. , 1992, Image--the journal of nursing scholarship.

[2]  J. Fleishman,et al.  Quality of Life in Persons with Human Immunodeficiency Virus Infection: Measurement by the Medical Outcomes Study Instrument , 1992, Annals of Internal Medicine.

[3]  H. Rubin,et al.  A Health Status Questionnaire Using 30 Items From The Medical Outcomes Study: Preliminary Validation in Persons With Early HIV Infection , 1991, Medical care.

[4]  E. Nelson,et al.  The Functional Status of Patients: How Can It Be Measured in Physicians' Offices? , 1990, Medical care.

[5]  J. Morrow,et al.  Quality of Life as a Function Of HIV Classification , 1990, Nursing research.

[6]  Douglas D. Richman,et al.  The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection a double-blind, placebo-controlled trial , 1990 .

[7]  S W Lagakos,et al.  Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection , 1990 .

[8]  R. Angel,et al.  Self-rated health and mortality in the NHANES-I Epidemiologic Follow-up Study. , 1990, American journal of public health.

[9]  M. Nettleman Outcome measurements in decision analysis: life versus quality of life. , 1989 .

[10]  Edward B. Perrin,et al.  The Medical Outcomes Study. An application of methods for monitoring the results of medical care , 1989 .

[11]  M. Bergner Quality of Life, Health Status, and Clinical Research , 1989, Medical care.

[12]  R M Kaplan,et al.  The Quality of Well-Being Scale: Applications in AIDS, Cystic Fibrosis, and Arthritis , 1989, Medical care.

[13]  A. Stewart,et al.  The MOS short-form general health survey. Reliability and validity in a patient population. , 1988, Medical care.

[14]  M A Fischl,et al.  The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. , 1987, The New England journal of medicine.

[15]  M A Fischl,et al.  The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. , 1987, The New England journal of medicine.

[16]  M. Bergner,et al.  A cross-cultural comparison of health status values. , 1985, American journal of public health.

[17]  M. Ganguli,et al.  Assessing depression in primary medical and psychiatric practices. , 1985, Archives of general psychiatry.

[18]  R. Deyo,et al.  Observer variability in the interpretation of lumbar spine radiographs. , 1985, Arthritis and rheumatism.

[19]  J. Ware Conceptualizing Disease Impact and Treatment Outcomes , 1984, Cancer.

[20]  R. Deyo,et al.  Measuring Functional Outcomes in Chronic Disease: A Comparison of Traditional Scales and a Self- Administered Health Status Questionnaire in Patients With Rheumatoid Arthritis , 1983, Medical care.

[21]  L. Chambers,et al.  The McMaster Health Index Questionnaire as a measure of quality of life for patients with rheumatoid disease. , 1982, The Journal of rheumatology.

[22]  F. Dam,et al.  Quality of Life: Some Theoretical Issues , 1981, Journal of clinical pharmacology.

[23]  E. Wagner,et al.  The Duke-UNC Health Profile: An Adult Health Status Instrument for Primary Care , 1981, Medical care.

[24]  M. Bergner,et al.  The Sickness Impact Profile: Development and Final Revision of a Health Status Measure , 1981, Medical care.

[25]  S P McKenna,et al.  The Nottingham Health Profile: subjective health status and medical consultations. , 1981, Social science & medicine. Part A, Medical sociology.

[26]  E. Berkanovic The effect of inadequate language translation on Hispanics' responses to health surveys. , 1980, American journal of public health.

[27]  M. Bergner,et al.  A Chicano version of the sickness impact profile (SIP) , 1980, Culture, medicine and psychiatry.

[28]  R. Brook Studies of process-outcome correlations in medical care evaluations. , 1979, Medical care.

[29]  P. Gertman,et al.  Utilization review in the United States: results from a 1976-1977 national survey of hospitals. , 1979, Medical care.

[30]  D. Karnofsky,et al.  The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma , 1948 .

[31]  Robert M. Kaplan,et al.  The Quality of Well-being Scale: rationale for a single quality of life index , 1993 .

[32]  M. Guttadauria,et al.  Methotrexate in Rheumatoid Arthritis: Impact on Quality of Life Assessed by Traditional Standard-Item and Individualized Patient Preference Health Status Questionnaires , 1990 .

[33]  P. Ganz,et al.  Assessing the quality of life--a study in newly-diagnosed breast cancer patients. , 1990, Journal of clinical epidemiology.

[34]  I Grant,et al.  Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex. , 1990, Journal of acquired immune deficiency syndromes.

[35]  M. Gottlieb,et al.  The relationship between medical and psychological status in newly diagnosed gay men with AIDS. , 1989, Psychiatric medicine.

[36]  Hellinger Fj National forecasts of the medical care costs of AIDS: 1988-1992. , 1988 .

[37]  N. Aaronson,et al.  A modular approach to quality-of-life assessment in cancer clinical trials. , 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[38]  A. Dobson,et al.  Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. , 1981, Journal of chronic diseases.

[39]  T. Hutchinson,et al.  Scientific problems in clinical scales, as demonstrated in the Karnofsky index of performance status. , 1979, Journal of chronic diseases.

[40]  K. Motamedi The quality of American life , 1976 .