Genome-wide association study of PR interval

Christian Gieger | Thomas Meitinger | Jan A. Kors | Gonçalo R. Abecasis | Eric Boerwinkle | Vilmundur Gudnason | Bertram Müller-Myhsok | Lenore J. Launer | Kenneth Rice | Joshua C. Bis | David Schlessinger | Jared W. Magnani | Fernando Rivadeneira | Man Li | Tamara B. Harris | Albert Hofman | Cornelia M. van Duijn | Aravinda Chakravarti | John Barnard | Patrick T. Ellinor | Steven A. Lubitz | Daniel Levy | Anna Köttgen | André G. Uitterlinden | Siegfried Perz | Stefan Kääb | Kathryn L. Lunetta | Serena Sanna | Jerome I. Rotter | Arne Pfeufer | Georg B. Ehret | Martin G. Larson | Bruce M. Psaty | Josef Coresh | Gudny Eiriksdottir | Thor Aspelund | Emelia J. Benjamin | Renate B. Schnabel | Susan R. Heckbert | Mina K. Chung | K. Lunetta | C. Gieger | A. Hofman | A. Uitterlinden | D. Levy | G. Abecasis | E. Boerwinkle | M. Chung | D. Schlessinger | V. Gudnason | E. Benjamin | R. Schnabel | P. Ellinor | R. Vasan | Albert Vernon Smith | A. Chakravarti | E. Lakatta | A. Köttgen | F. Rivadeneira | C. Duijn | J. Witteman | J. Coresh | T. Meitinger | M. Uda | Thomas J. Wang | B. Psaty | D. Arking | B. Stricker | C. Noord | C. Newton-Cheh | J. Rotter | A. Pfeufer | T. Harris | N. Sotoodehnia | K. Rice | C. V. van Duijn | E. Soliman | B. Müller-Myhsok | J. Bis | M. Larson | J. Barnard | G. Eiriksdottir | L. Launer | D. V. Van Wagoner | T. Aspelund | S. Heckbert | S. Perz | G. Ehret | S. Sanna | S. Najjar | G. Verwoert | Man Li | J. Kors | W. Kao | Martina Müller | S. Lubitz | Jonathan D. Smith | K. Tarasov | S. Kääb | K. Marciante | Á. Alonso | Moritz F. Sinner | B. Beckmann | J. Magnani | H. Wichmann | Christopher Newton-Cheh | Ramachandran S. Vasan | Nona Sotoodehnia | Alvaro Alonso | C. van Noord | W. Sauter | Charlotte van Noord | Dan E. Arking | Manuela Uda | Martina Müller | Wiebke Sauter | David R. Van Wagoner | Jacqueline C.M. Witteman | Elsayed Z. Soliman | Bruno H.C. Stricker | Edward Lakatta | Germaine C. Verwoert | Samer S. Najjar | Kirill V. Tarasov | Kristin D. Marciante | W.H. Linda Kao | Britt M. Beckmann | H.-Erich Wichmann | D. R. Wagoner | A. Smith | W. Kao | A. Smith | J. Coresh | A. Uitterlinden | A. Hofman | B. Psaty | Á. Alonso | D. Levy | C. Newton‐Cheh | Á. Alonso

[1]  Eric Boerwinkle,et al.  The Atherosclerosis Risk in Communities (ARIC) Study , 2011 .

[2]  Thomas Meitinger,et al.  Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation , 2010, Nature Genetics.

[3]  M. Gold,et al.  Long-term Outcomes in Individuals With Prolonged PR Interval or First-Degree Atrioventricular Block , 2010 .

[4]  Eric Boerwinkle,et al.  Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry , 2009, Nature Genetics.

[5]  Thomas Lumley,et al.  Common variants at ten loci influence QT interval duration in the QTGEN Study , 2009, Nature Genetics.

[6]  Christian Gieger,et al.  Common variants at ten loci modulate the QT interval duration in the QTSCD Study , 2009, Nature Genetics.

[7]  Zhu-ming Zhang,et al.  Ethnic Distribution of ECG Predictors of Atrial Fibrillation and Its Impact on Understanding the Ethnic Distribution of Ischemic Stroke in the Atherosclerosis Risk in Communities (ARIC) Study , 2009, Stroke.

[8]  D. Levy,et al.  Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study , 2009, The Lancet.

[9]  D. Levy,et al.  Prevention of Atrial Fibrillation: Report From a National Heart, Lung, and Blood Institute Workshop , 2009, Circulation.

[10]  Monique M. B. Breteler,et al.  The Rotterdam Study: 2016 objectives and design update , 2015, European Journal of Epidemiology.

[11]  G. Abecasis,et al.  Genotype imputation. , 2009, Annual review of genomics and human genetics.

[12]  Michael Krawczak,et al.  A comprehensive evaluation of SNP genotype imputation , 2009, Human Genetics.

[13]  K. Stankunas,et al.  Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease , 2008, Circulation research.

[14]  K. Mesbah,et al.  Tbx3 Is Required for Outflow Tract Development , 2008, Circulation research.

[15]  A. Moorman,et al.  A Gain-of-Function TBX5 Mutation Is Associated With Atypical Holt–Oram Syndrome and Paroxysmal Atrial Fibrillation , 2008, Circulation research.

[16]  M. Daly,et al.  Estimation of the multiple testing burden for genomewide association studies of nearly all common variants , 2008, Genetic epidemiology.

[17]  A. Wilde,et al.  Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations. , 2008, Trends in cardiovascular medicine.

[18]  T. Meitinger,et al.  The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG). , 2008, European heart journal.

[19]  G. Abecasis,et al.  Family-based association tests for genomewide association scans. , 2007, American journal of human genetics.

[20]  A. Hofman,et al.  The Rotterdam Study: objectives and design update , 2007, European Journal of Epidemiology.

[21]  D. Levy,et al.  Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study , 2007, BMC Medical Genetics.

[22]  Eric E. Smith,et al.  Variants conferring risk of atrial fibrillation on chromosome 4q25 , 2007, Nature.

[23]  J. Shendure,et al.  A Molecular Pathway Including Id2, Tbx5, and Nkx2-5 Required for Cardiac Conduction System Development , 2007, Cell.

[24]  Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures , 2007, Nature.

[25]  Qiong Yang,et al.  The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. , 2007, American journal of epidemiology.

[26]  M. Stephens,et al.  Imputation-Based Analysis of Association Studies: Candidate Regions and Quantitative Traits , 2007, PLoS genetics.

[27]  V. Gudnason,et al.  Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. , 2007, American journal of epidemiology.

[28]  A. Moorman,et al.  Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. , 2007, Genes & development.

[29]  Kazuko Koshiba-Takeuchi,et al.  Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. , 2006, Developmental biology.

[30]  G. Abecasis,et al.  Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians , 2006, PLoS genetics.

[31]  Christian Gieger,et al.  A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization , 2006, Nature Genetics.

[32]  A. Hofman,et al.  Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. , 2006, European heart journal.

[33]  Terence P. Speed,et al.  Genome analysis A genotype calling algorithm for affymetrix SNP arrays , 2005 .

[34]  C. Gieger,et al.  KORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[35]  M. Olivier.  A haplotype map of the human genome. , 2003, Nature.

[36]  M. Olivier.  A haplotype map of the human genome , 2003, Nature.

[37]  C. Berul,et al.  Function follows form: cardiac conduction system defects in Nkx2-5 mutation. , 2004, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[38]  J. Gamble,et al.  A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Ralph B D'Agostino,et al.  Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. , 2004, JAMA.

[40]  W. Sessa,et al.  Caveolae and Caveolins in the Cardiovascular System , 2004, Circulation research.

[41]  J. Ross,et al.  Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Michael Kühl,et al.  Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis , 2002, Nature.

[43]  Cynthia A. Carnes,et al.  C-Reactive Protein Elevation in Patients With Atrial Arrhythmias: Inflammatory Mechanisms and Persistence of Atrial Fibrillation , 2001, Circulation.

[44]  V. Lefebvre,et al.  The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. , 2001, Developmental cell.

[45]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[46]  S. Naylor,et al.  A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A , 1998, Pain.

[47]  J. L. Willems,et al.  The diagnostic performance of computer programs for the interpretation of electrocardiograms. , 1992, The New England journal of medicine.

[48]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.

[49]  J A Kors,et al.  Methodology of the Modular ECG Analysis System MEANS , 1990, Methods of Information in Medicine.

[50]  Aric Invest.  The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators , 1989 .

[51]  D. Lykken,et al.  Genetic factors in the electrocardiogram and heart rate of twins reared apart and together. , 1989, The American journal of cardiology.

[52]  A. Folsom,et al.  The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. , 1989, American journal of epidemiology.

[53]  R. Havlik,et al.  Variability of heart rate, P-R, QRS and Q-T durations in twins. , 1980, Journal of Electrocardiology.

[54]  S. Olsson,et al.  Monophasic action potential and sinus rhythm stability after conversion of atrial fibrillation. , 2009, Acta medica Scandinavica.