Standard Manufacturing Process and Validation of Roudra Rasa- A Rasausadhi Mentioned For Arbuda in Ayurveda

The one of the oldest system of medicine, Ayurveda is momentous in audience of worldwide by virtue of its holistic approach of life. Techniques used in Rasa Shastra like shodhana, marana, bhavana acclimatize the toxic principles into effective remedies known as herbo mineral formulations (Rasaoushadhies) in Ayurveda. Roudra rasa is a herbo mineral formulation which has been indicated to treat arbuda. Arbuda is the Sanskrit word used for tumor. According to Sushruta the three doshas (Vata, Pitta and Kapha) when aggravated, may develop a tumor; especially aggravated Kapha and Vata doshas. This affects the tissue, which might result in developing a malignant tumor. The basic material used to prepare Roudra rasa is kajjali followed by sequential bhavana (levigation) of herbal drugs. Since the poly herbo mineral formulation is heat sensitive, laghu puta is mentioned for its marana. The technique of giving bhavana to metallic or mineral preparation lies in the fact that to bring minute particles of the material in contact with the liquid media, transformation of the coarse powder to a finer state, impregnation of the properties of the media into the material so as to establish stable, unique physico-chemical changes i.e. introduction of trace elements from the herbal juices to potentiate its efficacy and further facilitate the process of marana. Two different samples of Roudra rasa have been prepared, one of which involves Hinguluttha parada, considered as the most superior as per classical literature and a complete SOP of the formulations has been validated. Moreover validation of SOP can never be free from precautionary measures. The technique of bhavana in generally leads to an increase in weight provided it is done under suitable climatic conditions to facilitate the process of drying. Thus considering the industrial aspect of the formulation loss of sample during the process of bhavana should be optimized by using technical instruments