Synthesis, magnetic and spectral studies of chromium(III), manganese(III), iron(III) and cobalt(III) complexes of thiosemicarbazones derived from benzil α-monoxime and unsubstituted/substituted thiosemicarbazides as biological agents

Cr(III), Mn(III), Fe(III) and Co(III) complexes of thiosemicarbazones, derived from benzil α-monoxime and thiosemicarbazides (BMTH2), benzil α-monoxime and phenyl thiosemicarbazides (BMPTH2), benzil α-monoxime and 4-bromophenyl thiosemicarbazides (BMBTH2), benzil α-monoxime and 4-chlorophenyl thiosemicarbazides (BMCTH2) and benzil α-monoxime and 4-nitrophenyl thiosemicarbazides (BMNTH2), have been prepared. These complexes have been characterized by elemental analyses, magnetic susceptibilities, molar conductance measurements, electronic, IR, 1H and 13C NMR spectra (in the case of Co(III) complexes), FAB mass spectra and thermogravimetric analysis to arrive at the geometry of the ligand environment around the metal ion and to elucidate the bonding sites of the ligands with the central metal. The complexes contain two monoprotonic tridentate ligands with NNS donor sites. Coordination to metal ion the oxime nitrogen, imine nitrogen and thione sulfur is confirmed in the complexes by IR spectral studies. The antifungal and antibacterial activities of the ligands and complexes have been screened.

[1]  S. Keller.  Polyhedron , 2020, Encyclopedia of Database Systems.

[2]  S. Perlepes,et al.  The Coordination Chemistry of Pyridyl Oximes , 2006 .

[3]  A. El-asmy,et al.  Synthesis and spectroscopic characterization of new mono- and binuclear complexes of some NH(1) thiosemicarbazides , 2005 .

[4]  N. S. Youssef,et al.  Synthesis and Characterization of some Transition Metal Complexes of Thiosemicarbazones Derived from 2‐acetylpyrrole and 2‐acetylfuran , 2005 .

[5]  M. Maurya,et al.  Novel bidentate complexes of Cu(II) derived from 5-nitrofuran-2-carboxaldehyde thiosemicarbazones with antiamoebic activity against E. histolytica. , 2005, European journal of medicinal chemistry.

[6]  M. El-Shahawi,et al.  Spectral, magnetic, thermal and electrochemical studies on new copper(II) thiosemicarbazone complexes , 2005 .

[7]  S. Srivastava,et al.  Synthesis, Spectroscopic and Antifungal Studies of Trivalent Chromium, Manganese, Iron and Cobalt Complexes with Hydrazones Derived from Benzil α‐Monoxime and Various Aromatic Hydrazides , 2005 .

[8]  M. El-Shahawi,et al.  Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes. , 2005, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[9]  L. Zakharov,et al.  Appended 1,2-naphthoquinones as anticancer agents 1: synthesis, structural, spectral and antitumor activities of ortho-naphthaquinone thiosemicarbazone and its transition metal complexes ☆ , 2004 .

[10]  S. Chandra,et al.  EPR, magnetic and spectral studies of copper(II) and nickel(II) complexes of schiff base macrocyclic ligand derived from thiosemicarbazide and glyoxal. , 2004, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[11]  A. Sousa-Pedrares,et al.  Copper(II) and nickel(II) complexes of 5-methyl-2-hydroxyacetophenone N(4)-substituted thiosemicarbazones , 2003 .

[12]  P. Chaudhuri.  Homo- and hetero-polymetallic exchange coupled metal-oximates , 2003 .

[13]  R. Butcher,et al.  Synthesis and spectroscopic characterisation of cobalt(III) and nickel(II) complexes with 5-methyl-3-formylpyrazole-N(4)-dibutylthiosemicarbazone (HMPzNBu2): X-ray crystallography of [Co(MPzNBu2)2]NO3·H2O (I) and [Ni(HMPzNBu2)2](ClO4)2 (II) , 2003 .

[14]  K. Cavell,et al.  Synthesis, characterisation and catalytic behaviour of a novel class of chromium(III) and vanadium(III) complexes containing bi- and tri-dentate imidazole chelating ligands: a comparative study , 2002 .

[15]  R. Karvembu,et al.  SYNTHESIS, CHARACTERISATION, CATALYTIC, AND BIOCIDAL STUDIES OF RUTHENIUM(III) COMPLEXES WITH THIOSEMICARBAZONES OF β-DIKETOESTERS , 2002 .

[16]  R. Butcher,et al.  Synthesis and spectroscopic studies of cobalt(III) complexes with 5-methyl-3-formylpyrazole-N(4)-diethylthiosemicarbazone (HMPzNEt2): X-ray crystallography of [Co(MPzNEt2)2]ClO4·2H2O (I) and [Co(MPzNEt2)2]BF4·2H2O (II) , 2002 .

[17]  H. Beraldo,et al.  Cobalt(II) and nickel(II) complexes of N(4′) substituted 3- and 4-acetylpyridine thiosemicarbazones , 2002 .

[18]  J. Turner.  Ligand Field Theory and Its Applications (Book) , 2002 .

[19]  Yi-zhi Li,et al.  Antitumour activity of transition metal complexes with the thiosemicarbazone derived from 3-acetylumbelliferone , 2001 .

[20]  J. Casas,et al.  Corrigendum to “Main group metal complexes of semicarbazones and thiosemicarbazones. A structural review” , 2000 .

[21]  P. Lunghi,et al.  Synthesis, spectroscopic characterization and biological properties of new natural aldehydes thiosemicarbazones. , 2000, Bioorganic & medicinal chemistry.

[22]  B. Figgis,et al.  Ligand Field Theory and Its Applications , 1999 .

[23]  B. K. Srivastava,et al.  Synthesis, structural and biochemical aspects of titanocene and zirconocene chelates of acetylferrocenyl thiosemicarbazones , 1998 .

[24]  K. Reddy,et al.  Synthesis and spectral studies of novel copper(II) chelates of sulphur-containing oximes , 1994 .

[25]  S. Cotton.  Elements of Magnetochemistry , 1994 .

[26]  B. Douglas,et al.  Synthesis and characterization of hexadentate cobalt(III) complexes with new edta-type ligands Part 3. Circular dichroism of cobalt(III) complexes of ethylenediamine-N,N,N′-triacetic-N′-3-propionic acid and ethylenediamine-N,N,-diacetic-N′,N′-di-3-propionic acid , 1993 .

[27]  V. Sharma,et al.  Synthesis and Spectroscopic Studies on Ruthenium (III) and Rhodium (III) Derivatives with Thiohydantoins , 1993 .

[28]  S. Padhye,et al.  Thiosemicarbazone complexes of copper(II): structural and biological studies , 1993 .

[29]  M. C. Rodríguez-Argüelles,et al.  Dimethylthallium(III) and methylmercury(II) derivatives of pyridine-2-carbaldehyde thiosemicarbazone: synthesis and structure , 1993 .

[30]  V. Sharma,et al.  Synthesis and Physicochemical Studies on Ruthenium(III) and Rhodium(III) Complexes with Chalcone Oximes , 1991 .

[31]  M. Lanfranchi,et al.  Thiosemicarbazones as co-ordinating agents. Part 4. Synthesis, spectroscopic characterization and X-ray structure of two cobalt(III) complexes with pyridoxal thiosemicarbazone , 1991 .

[32]  S. Padhye,et al.  Structural and physical correlations in the biological properties of transition metal heterocyclic thiosemicarbazone and S -alkyldithiocarbazate complexes , 1991 .

[33]  Mosarraf Hossain,et al.  Ligational behaviour of two biologically active N−S donors towards cobalt(III), iron(III), iron(II) and rhodium(III) , 1990 .

[34]  Ronald Bartzatt,et al.  Synth. React. Inorg. Met-Org. Chem , 1985 .

[35]  D. L. Klayman,et al.  2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents. , 1983, Journal of medicinal chemistry.

[36]  D. D. Perrin,et al.  Viral chemotherapy: antiviral actions of metal ions and metal-chelating agents. , 1981, Pharmacology & therapeutics.

[37]  D. Petering,et al.  Some properties of copper and zinc complexes of 2-formylpyridine thiosemicarbazone , 1977 .

[38]  J. Tuite.  Plant pathological methods : fungi and bacteria , 1970 .

[39]  Stuart A. Rice,et al.  Inorganic Electronic Spectroscopy , 1968 .

[40]  C. Ballhausen,et al.  Introduction to Ligand Field Theory , 1962 .

[41]  J. W. COOK,et al.  A Text-Book of Practical Organic Chemistry , 1948, Nature.

[42]  C. A. Shull.  Phytopathology , 1929, Botanical Gazette.