Safety of metamizole: a systematic review of the literature

Metamizole was withdrawn from the market in the United States and several European countries following reports of fatal agranulocytosis among users, but is still available in many countries in Europe, South America and Asia. Over the past several decades, a number of epidemiologic studies have been conducted to quantify the risk of agranulocytosis and other adverse effects associated with metamizole and other non‐narcotic analgesics. The objective of this study was to perform a systematic review of the safety of metamizole.

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