Vancomycin-Induced Neutropenia during Treatment of Osteomyelitis in an Outpatient

A case of vancomycin-associated neutropenia occurring during long-term outpatient therapy with vancomycin is described. Pharmacokinetic studies demonstrated that the patient's vancomycin serum levels were within an acceptable range during treatment. Eighteen other reported cases of vancomycin-associated leukopenia are discussed in brief. An immunologic mechanism has been proposed but a clear understanding is lacking. Patients receiving long-term vancomycin therapy should have their white blood cell counts periodically monitored.

[1]  J. Mordenti,et al.  Vancomycin-induced neutropenia complicating bone marrow recovery in a patient with leukemia. Case report and review of the literature. , 1986, The American journal of medicine.

[2]  B. Ackerman,et al.  Vancomycin and red necks. , 1985, Annals of internal medicine.

[3]  A. Heaton,et al.  THROMBOCYTOPENIA DUE TO VANCOMYCIN , 1985, The Lancet.

[4]  R. Mackett,et al.  Vancomycin-induced neutropenia. , 1985, Canadian Medical Association journal.

[5]  Glew Rh,et al.  Delayed appearance of vancomycin-induced neutropenia in a patient with chronic renal failure. , 1984 .

[6]  B. Farber,et al.  Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981 , 1983, Antimicrobial Agents and Chemotherapy.

[7]  D. Brown,et al.  Acute idiosyncratic reaction to hydrochlorothiazide ingestion. , 1983, The Western journal of medicine.

[8]  F. R. Venezio,et al.  Vancomycin-induced neutropenia. , 1982, The Journal of infectious diseases.

[9]  J. Silva,et al.  Neutropenia associated with vancomycin therapy. , 1982, Southern medical journal.

[10]  T. Sorrell,et al.  Vancomycin therapy for methicillin-resistant Staphylococcus aureus. , 1982, Annals of internal medicine.

[11]  A. Gilbert,et al.  Intravenous antibiotic therapy in an outpatient setting. , 1982, JAMA.

[12]  P. Frame.  Outpatient intravenous antibiotic therapy. , 1982, JAMA.

[13]  West Bc.  Vancomycin-induced neutropenia. , 1981 .

[14]  W. J. Rahill,et al.  VANCOMYCIN INDUCED NEUTROPENIA , 1981, The Lancet.

[15]  C. Borland,et al.  Reversible neutropenia from vancomycin. , 1979, JAMA.

[16]  M. Roizen,et al.  Hazards of rapid administration of vancomycin. , 1979, Annals of internal medicine.

[17]  W. Johnson,et al.  Vancomycin therapy of bacterial endocarditis. , 1978, The American journal of medicine.

[18]  S. Weitzman,et al.  DRUG-INDUCED IMMUNOLOGICAL NEUTROPENIA , 1978, The Lancet.

[19]  H. D. Riley.  Vancomycin and ristocetin. , 1961, Pediatric clinics of North America.