The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging.

[1]  W. Janssen,et al.  Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. , 2008, American journal of respiratory and critical care medicine.

[2]  G. Snyder,et al.  Surfactant protein D is expressed and modulates inflammatory responses in human coronary artery smooth muscle cells. , 2008, American journal of physiology. Heart and circulatory physiology.

[3]  P. Libby.  The molecular mechanisms of the thrombotic complications of atherosclerosis , 2008, Journal of internal medicine.

[4]  Günter Siegel,et al.  Atherosclerosis, an inflammatory and fibroproliferative disease , 2007 .

[5]  C. Siu,et al.  Genomic Changes in Regenerated Porcine Coronary Arterial Endothelial Cells , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[6]  A. Easton,et al.  Apoptotic Phenotype Alters the Capacity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand to Induce Human Vascular Endothelial Activation , 2007, Journal of Vascular Research.

[7]  N. Gokce,et al.  Endothelial dysfunction in obesity: etiological role in atherosclerosis , 2007, Current opinion in endocrinology, diabetes, and obesity.

[8]  C. Lowenstein,et al.  Nitric oxide regulation of protein trafficking in the cardiovascular system. , 2007, Cardiovascular research.

[9]  U. Holmskov,et al.  Plasma Surfactant Protein D Levels and the Relation to Body Mass Index in a Chinese Population , 2007, Scandinavian journal of immunology.

[10]  U. Holmskov,et al.  Surfactant protein A and surfactant protein D variation in pulmonary disease. , 2007, Immunobiology.

[11]  U. Holmskov,et al.  Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D , 2007, Respiratory research.

[12]  T. Sørensen,et al.  Surfactant Protein D of the Innate Immune Defence is Inversely Associated with Human Obesity and SP‐D Deficiency Infers Increased Body Weight in Mice , 2006, Scandinavian journal of immunology.

[13]  D. Rowlands,et al.  The Isoflavone Equol Mediates Rapid Vascular Relaxation , 2006, Journal of Biological Chemistry.

[14]  E. Falk,et al.  Surfactant protein D is proatherogenic in mice. , 2006, American journal of physiology. Heart and circulatory physiology.

[15]  J. Whitsett,et al.  In defense of the lung: surfactant protein A and surfactant protein D. , 2006, Current opinion in pharmacology.

[16]  M. Quon,et al.  Inflammatory markers and the metabolic syndrome: insights from therapeutic interventions. , 2005, Journal of the American College of Cardiology.

[17]  T. Maeda,et al.  High serum TNF-alpha level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells. , 2005, Journal of diabetes and its complications.

[18]  D. Harrison,et al.  A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription. , 2005, Journal of molecular and cellular cardiology.

[19]  Jie Wu,et al.  Flow Shear Stress Stimulates Gab1 Tyrosine Phosphorylation to Mediate Protein Kinase B and Endothelial Nitric-oxide Synthase Activation in Endothelial Cells* , 2005, Journal of Biological Chemistry.

[20]  U. Holmskov,et al.  A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D1 , 2005, The Journal of Immunology.

[21]  U. Holmskov,et al.  Purification, characterization and immunolocalization of porcine surfactant protein D , 2005, Immunology.

[22]  A. Passaniti,et al.  Insulin-like Growth Factor-1 Regulates Endogenous RUNX2 Activity in Endothelial Cells through a Phosphatidylinositol 3-Kinase/ERK-dependent and Akt-independent Signaling Pathway* , 2004, Journal of Biological Chemistry.

[23]  J. VandeBerg,et al.  Passage-dependent changes in baboon endothelial cells--relevance to in vitro aging. , 2004, DNA and cell biology.

[24]  Peter Boer,et al.  Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells. , 2004, American journal of physiology. Heart and circulatory physiology.

[25]  Z. Ungvari,et al.  Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. , 2004, Physiological genomics.

[26]  Andrew J Gow,et al.  Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. , 2004, American journal of respiratory cell and molecular biology.

[27]  U. Holmskov,et al.  Surfactant protein D in the female genital tract. , 2004, Molecular human reproduction.

[28]  I. Komuro,et al.  Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway , 2004, The EMBO journal.

[29]  S. Thiel,et al.  Collections and ficolins: humoral lectins of the innate immune defense. , 2003, Annual review of immunology.

[30]  J. Nick,et al.  By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance Inflammation , 2003, Cell.

[31]  P. Vanhoutte.  Endothelial control of vasomotor function: from health to coronary disease. , 2003, Circulation journal : official journal of the Japanese Circulation Society.

[32]  T. Benzing,et al.  Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. , 2003, Nitric oxide : biology and chemistry.

[33]  P. Secchiero,et al.  TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways , 2003, Circulation.

[34]  N. Kalinina,et al.  Proliferative Activity and Expression of Cyclin-Dependent Kinase Inhibitor p21WAF1 and p53 Protein in Endothelial Cells of Human Aorta during Replicative Aging in Vitro , 2002, Bulletin of Experimental Biology and Medicine.

[35]  K. Hartshorn,et al.  Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers. , 2002, American journal of respiratory cell and molecular biology.

[36]  M. Sack.  Tumor necrosis factor-α in cardiovascular biology and the potential role for anti-tumor necrosis factor-α therapy in heart disease , 2002 .

[37]  A. Zeiher,et al.  Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli: Important Role of Nitric Oxide , 2001, Circulation research.

[38]  I. Spyridopoulos,et al.  In Vivo Blockade of Tumor Necrosis Factor-&agr; Accelerates Functional Endothelial Recovery After Balloon Angioplasty , 2001, Circulation.

[39]  J. Bourbon,et al.  Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance. , 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[40]  I. Morita,et al.  Inhibition of phosphatidylinositol-3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-α cytotoxicity , 2001, Cell Death and Differentiation.

[41]  T. Michel,et al.  Bradykinin-regulated Interactions of the Mitogen-activated Protein Kinase Pathway with the Endothelial Nitric-oxide Synthase* , 2000, The Journal of Biological Chemistry.

[42]  U. Holmskov,et al.  Localization of Lung Surfactant Protein D on Mucosal Surfaces in Human Tissues1 , 2000, The Journal of Immunology.

[43]  F. Natividad,et al.  Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[44]  P. Vanhoutte,et al.  Phenotypic and functional changes in regenerated porcine coronary endothelial cells : increased uptake of modified LDL and reduced production of NO. , 2000, Circulation research.

[45]  H. Haagsman,et al.  Porcine Lung Surfactant Protein D: Complementary DNA Cloning, Chromosomal Localization, and Tissue Distribution1 2 , 2000, The Journal of Immunology.

[46]  R. Ross,et al.  Atherosclerosis is an inflammatory disease. , 1998, American heart journal.

[47]  P. Vanhoutte,et al.  Endothelial dysfunction and atherosclerosis. , 1997, European heart journal.

[48]  H. Rubin,et al.  Cell aging in vivo and in vitro , 1997, Mechanisms of Ageing and Development.

[49]  T. Lüscher,et al.  Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. , 1996, The Journal of clinical investigation.

[50]  A. Tauber,et al.  Mouse surfactant protein-D. cDNA cloning, characterization, and gene localization to chromosome 14. , 1995, Journal of immunology.

[51]  T. Lüscher,et al.  The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator. , 1995, Atherosclerosis.

[52]  W E Haefeli,et al.  Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. , 1995, Circulation.

[53]  N. Flavahan.  Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. , 1992, Circulation.

[54]  S. Moncada,et al.  Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[55]  H. Shimokawa,et al.  Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. , 1987, Circulation research.

[56]  R. Busse,et al.  Endothelial aging. , 2005, Cardiovascular research.

[57]  M. Sack.  Tumor necrosis factor-alpha in cardiovascular biology and the potential role for anti-tumor necrosis factor-alpha therapy in heart disease. , 2002, Pharmacology & therapeutics.

[58]  P. Vanhoutte.  Endothelial dysfunction and atherosclerosis | Dysfonctionnement endothelial et atherosclerose , 1997 .

[59]  A. Persson,et al.  Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. , 1993, The American journal of pathology.