Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body.

Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.

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