A rabbit sized phantom for validation of quantitative imaging of magnetic nanoparticle distributions

To tailor magnetic nanoparticles (MNP) for peculiar biomedical applications qualitative and quantitative information about the particles and their magnetic characteristics is required. In biological environments effects like immobilization and aggregation may alter the magnetic behavior and biomedical functionality of the particles. In this study we deliberately aggregated MNP to examine their magnetic properties applying temperature dependent magnetorelaxometry (TMRX). We found that the underlying interaction process is independent from the macroscopic concentration and thus a well known quantification method could be employed in this case as well.