Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor.

[1]  T. Bäckström,et al.  3Beta-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABA(A) receptor through different channel property. , 2007, European journal of pharmacology.

[2]  T. Bäckström,et al.  Neurosteroid modulation of allopregnanolone and GABA effect on the GABA-A receptor , 2006, Neuroscience.

[3]  T. Bäckström,et al.  Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus , 2005, Brain Research.

[4]  Deepani Jinadasa,et al.  Slow Actions of Neuroactive Steroids at GABAA Receptors , 2004, The Journal of Neuroscience.

[5]  C. Zorumski,et al.  Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. , 2004, Molecular pharmacology.

[6]  K. Miczek,et al.  Neurosteroids, GABAA receptors, and escalated aggressive behavior , 2003, Hormones and Behavior.

[7]  T. Bäckström,et al.  Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3β-hydroxy-5α-pregnan-20-one (isoallopregnanolone) , 2003, Brain Research.

[8]  C. Zorumski,et al.  Activation‐Dependent Properties of Pregnenolone Sulfate Inhibition of GABAA Receptor‐Mediated Current , 2003, The Journal of physiology.

[9]  D. Reddy.  The clinical potentials of endogenous neurosteroids. , 2002, Drugs of today.

[10]  C. Zorumski,et al.  Recent developments in structure–activity relationships for steroid modulators of GABAA receptors , 2001, Brain Research Reviews.

[11]  W. Shen,et al.  Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission. , 2001, Molecular pharmacology.

[12]  S. Smith,et al.  Short-term exposure to a neuroactive steroid increases α4 GABAA receptor subunit levels in association with increased anxiety in the female rat , 2001, Brain Research.

[13]  K. Miczek,et al.  Alcohol, allopregnanolone and aggression in mice , 2001, Psychopharmacology.

[14]  R. Beninger,et al.  Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats , 2000, Pharmacology Biochemistry and Behavior.

[15]  K. Isenberg,et al.  Potential clinical uses of neuroactive steroids. , 2000, Current opinion in investigational drugs.

[16]  C. Zorumski,et al.  Pregnenolone Sulfate Modulates Inhibitory Synaptic Transmission by Enhancing GABAA Receptor Desensitization , 2000, The Journal of Neuroscience.

[17]  R. Macdonald,et al.  GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts , 1999 .

[18]  R. Chapell,et al.  Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors. , 1997, Brain research. Molecular brain research.

[19]  N L Harrison,et al.  Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform. , 1997, Biophysical journal.

[20]  S. Vicini,et al.  Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States , 1997, The Journal of Neuroscience.

[21]  G. Westbrook,et al.  Desensitized states prolong GABAA channel responses to brief agonist pulses , 1995, Neuron.

[22]  L. Stein,et al.  Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents , 1995, Psychopharmacology.

[23]  R K Wong,et al.  Multiphasic desensitization of the GABAA receptor in outside-out patches. , 1994, Biophysical journal.

[24]  S. Paul,et al.  Anxiolytic activity of an endogenous adrenal steroid , 1986, Brain Research.

[25]  Doodipala Samba Reddy,et al.  Pharmacology of endogenous neuroactive steroids. , 2003, Critical reviews in neurobiology.

[26]  J. A. Peters,et al.  Neurosteroid modulation of GABAA receptors. , 2003, Progress in neurobiology.

[27]  J. A. Peters,et al.  Steroid Modulation of GABAA Receptors , 2001 .

[28]  S. Kulkarni,et al.  Development of neurosteroid-based novel psychotropic drugs. , 2000, Progress in medicinal chemistry.

[29]  R. Macdonald,et al.  GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. , 1999, The Journal of physiology.

[30]  L. Stein,et al.  Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents. , 1995, Psychopharmacology.