Histologic and histochemical evidence concerning the presence of morphologically distinct cellular zones within the rabbit atrioventricular node

The rabbit atrioventricular nodal region has been studied using a method of tissue preparation allowing direct comparison of adjacent sections processed by histological and histochemical techniques. By this means, specialized cardiac tissue is found to occupy the region defined electrophysiologically as the atrioventricular node. This region is more extensive than that previously defined by light microscopy. Within this region three types of cell are distinguishable; transitional cells, and upper and lower nodal cells. The last are continuous with and identical to the cells of the atrioventricular bundle. The cell types also exhibit differences in their pattern of innervation. The significance of these cellular zones and their associated nerves is discussed with reference to previous electrophysiological findings and the mechanism of nodal delay.

[1]  R. Anderson,et al.  The cellular architecture of the human atrioventricular node, with a note on its morphology in the presence of a left superior vena cava. , 1971, Journal of anatomy.

[2]  J. Gosling,et al.  Morphologic evidence that rhe renal calyx and pelvis control ureteric activity in the rabbit. , 1971, The American journal of anatomy.

[3]  C. E. Challice,et al.  Studies on the impulse conducting pathways in the atrium of the mammalian heart. , 1970, American heart journal.

[4]  M J Janse,et al.  Influence of the direction of the atrial wave front on A-V nodal transmission in isolated hearts of rabbits. , 1969, Circulation research.

[5]  L. DeFelice,et al.  Anatomical and Ultrastructural Study of the Electrophysiological Atrioventricular Node of the Rabbit , 1969, Circulation research.

[6]  A. Wallace,et al.  The Identification and Surgical Significance of the Atrial Internodal Conduction Tracts , 1968, Annals of surgery.

[7]  T. N. James,et al.  Anatomy of the Cardiac Conduction System in the Rabbit , 1967, Circulation research.

[8]  P. Rees,et al.  Controlled formaldehyde-catecholamine condensation in cryostat sections to show adrenergic nerves by fluorescence. , 1966, Stain technology.

[9]  G. Moe,et al.  Demonstration of a Dual A‐V Nodal Conduction System in the Isolated Rabbit Heart , 1966, Circulation research.

[10]  C. Wensing.  Nature of Impulse Origin and Conduction in the Mammalian Heart , 1966, Nature.

[11]  B. Hoffman,et al.  Nature of Impulse Origin and Conduction in the Mammalian Heart , 1966, Nature.

[12]  L. Dreifus,et al.  Inhomogeneous conduction in the A-V node. A model for re-entry. , 1965, American heart journal.

[13]  C. Wensing.  Evidence for Neurogenic Conduction in the Mammalian Heart , 1965, Nature.

[14]  T. N. James,et al.  THE CONNECTING PATHWAYS BETWEEN THE SINUS NODE AND A-V NODE AND BETWEEN THE RIGHT AND THE LEFT ATRIUM IN THE HUMAN HEART. , 1963, American heart journal.

[15]  H. Torii.  Electron Microscope Observations of the S.A and A.V Nodes and Purkinje Fibers of the Rabbit , 1962 .

[16]  T. N. James,et al.  Morphology of the human atrioventricular node, with remarks pertinent to its electrophysiology. , 1961, American heart journal.

[17]  A. Kistin.  Mechanisms determining reciprocal rhythm initiated by ventricular premature systoles; multiple pathways of conduction. , 1959, The American journal of cardiology.

[18]  B. Hoffman,et al.  Effects of Acetylcholine on Single Fibers of the Atrioventricular Node , 1959, Circulation research.

[19]  B. Hoffman,et al.  Electrical Activity of Single Fibers of the Atrioventricular Node , 1959, Circulation research.

[20]  J. B. Preston,et al.  Physiologic Evidence for a Dual A‐V Transmission System , 1956, Circulation research.

[21]  D. Glomset,et al.  A morphologic study of the cardiac conduction system in ungulates, dog, and man , 1940 .

[22]  W. Lloyd.  The form and function of the auriculo-ventricular bundle in the rabbit† , 1930 .

[23]  W. J. Meek,et al.  EXPERIMENTS ON THE ORIGIN AND CONDUCTION OF THE CARDIAC IMPULSE: VI. CONDUCTION OF THE EXCITATION FROM THE SINO-AURICULAR NODE TO THE RIGHT AURICLE AND AURICULOVENTRICULAR NODE , 1916 .

[24]  A. Todrick,et al.  The use of a selective acetylcholinesterase inhibitor in the estimation of pseudocholinesterase activity in rat brain. , 1956, The Biochemical journal.