论文信息 - Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41. - 字舞流文

Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41.

A. Debnath | A. Katritzky | Hong Lu | Shibo Jiang | Peng Zou | T. Ibrahim | S. R. Tala | I. Avan | Abdelmotaal Abdelmajeid | Nader E Abo-Dya | İ. Avan

[1] A. Debnath,et al. Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41. , 2011, Journal of medicinal chemistry.

[2] A. Debnath,et al. Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors. , 2009, Journal of medicinal chemistry.

[3] Shibo Jiang,et al. HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds. , 2007, Current pharmaceutical design.

[4] A. Debnath,et al. N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion , 2004, Antimicrobial Agents and Chemotherapy.

[5] R. Doms,et al. The entry of entry inhibitors: A fusion of science and medicine , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[6] P S Kim,et al. Mechanisms of viral membrane fusion and its inhibition. , 2001, Annual review of biochemistry.

[7] P S Kim,et al. Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8] F. Arndt,et al. Synthesen von Thiazolo- und [1,3]Thiazino[1,2,4]triazinonen , 1984 .