Packed-bed reactors for continuous-flow C-N cross-coupling.

[1]  Yangjie Wu,et al.  Amination of aryl chlorides in water catalyzed by cyclopalladated ferrocenylimine complexes with commercially available monophosphinobiaryl ligands , 2007 .

[2]  Klavs F. Jensen,et al.  Silicon-Based Microchemical Systems: Characteristics and Applications , 2006 .

[3]  J. Kobayashi,et al.  Multiphase organic synthesis in microchannel reactors. , 2006, Chemistry, an Asian journal.

[4]  Holger Löwe,et al.  Chemie in Mikrostrukturreaktoren , 2004 .

[5]  A. deMello Control and detection of chemical reactions in microfluidic systems , 2006, Nature.

[6]  S. Buchwald,et al.  Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions. , 2003 .

[7]  Paul Watts,et al.  Recent advances in synthetic micro reaction technology. , 2007, Chemical communications.

[8]  U. Scholz,et al.  Palladium‐Catalyzed CN and CO Coupling–A Practical Guide from an Industrial Vantage Point† , 2004 .

[9]  K. Gothelf,et al.  Effect of water on the palladium-catalyzed amidation of aryl bromides. , 2005, Journal of Organic Chemistry.

[10]  F. Schubert,et al.  Palladium-catalyzed amination of aromatic halides in water-containing solvent systems: a two-phase protocol , 1998 .

[11]  S. Nolan,et al.  Amination reactions of aryl halides with nitrogen-containing reagents mediated by palladium/imidazolium salt systems. , 2001, The Journal of organic chemistry.

[12]  Ryan L Hartman,et al.  Microchemical systems for continuous-flow synthesis. , 2009, Lab on a chip.

[13]  Stephen L. Buchwald,et al.  Biarylphosphanliganden in der palladiumkatalysierten Aminierung , 2008 .

[14]  T. Wirth,et al.  Advanced organic synthesis using microreactor technology. , 2007, Organic & biomolecular chemistry.

[15]  Jun-ichi Yoshida,et al.  Enhancement of Chemical Selectivity by Microreactors , 2005 .

[16]  S. Buchwald,et al.  A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides. , 2008, Journal of the American Chemical Society.

[17]  D. Popa,et al.  Towards Continuous Flow, Highly Enantioselective Allylic Amination: Ligand Design, Optimization and Supporting , 2009 .

[18]  Dominique M. Roberge,et al.  Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries? , 2005 .

[19]  S. Buchwald,et al.  Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases. , 2006, The Journal of organic chemistry.

[20]  Gerard Mignani,et al.  Successful application of microstructured continuous reactor in the palladium catalysed aromatic amination , 2005 .

[21]  Paul Watts,et al.  Benchmarking of Microreactor Applications , 2004 .

[22]  H. Löwe,et al.  Chemistry in microstructured reactors. , 2004, Angewandte Chemie.

[23]  S. Stauffer,et al.  Pd-catalyzed amination in a polar medium: rate enhancement, convenient product isolation, and tandem Suzuki cross-coupling , 2005 .

[24]  Paul Watts,et al.  Micro reactors: principles and applications in organic synthesis , 2002 .

[25]  Albert van den Berg,et al.  On-microchip multiphase chemistry - a review of microreactor design principles and reagent contacting modes , 2005 .

[26]  S. Nolan,et al.  Well-defined N-heterocyclic carbenes-palladium(II) precatalysts for cross-coupling reactions. , 2008, Accounts of chemical research.

[27]  K. Jensen Microchemical systems for discovery and development. , 2006, Ernst Schering Foundation symposium proceedings.

[28]  J. S. Carey,et al.  Analysis of the reactions used for the preparation of drug candidate molecules. , 2006, Organic & biomolecular chemistry.

[29]  D. Ripin,et al.  Survey of GMP Bulk Reactions Run in a Research Facility between 1985 and 2002 , 2005 .

[30]  S. Morin,et al.  Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. , 2008, Chemistry.

[31]  Jeremy L. Steinbacher,et al.  Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.

[32]  A. Kozikowski,et al.  Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents. , 2010, Journal of medicinal chemistry.

[33]  A. Bogdan,et al.  A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactor , 2009, Beilstein journal of organic chemistry.

[34]  M. Krohn,et al.  Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. , 2010, Journal of medicinal chemistry.

[35]  Kevin H Shaughnessy,et al.  Hydrophilic ligands and their application in aqueous-phase metal-catalyzed reactions. , 2009, Chemical reviews.

[36]  Gitte Van Baelen,et al.  Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination , 2008 .

[37]  S. Buchwald,et al.  Biaryl phosphane ligands in palladium-catalyzed amination. , 2008, Angewandte Chemie.

[38]  B. Lipshutz,et al.  Aminations of Aryl Bromides in Water at Room Temperature. , 2009, Advanced synthesis & catalysis.

[39]  M. Decker,et al.  Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. , 2010, Journal of medicinal chemistry.

[40]  Harold N Weller,et al.  Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis. , 2006, Journal of combinatorial chemistry.

[41]  K. Jensen Microreaction engineering * is small better? , 2001 .

[42]  S. Buchwald,et al.  A highly active catalyst for Pd-catalyzed amination reactions: cross-coupling reactions using aryl mesylates and the highly selective monoarylation of primary amines using aryl chlorides. , 2008, Journal of the American Chemical Society.

[43]  Peter H Seeberger,et al.  Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? , 2006, Chemistry.

[44]  J. Hartwig Evolution of a fourth generation catalyst for the amination and thioetherification of aryl halides. , 2008, Accounts of chemical research.

[45]  Volker Hessel,et al.  Organic Synthesis with Microstructured Reactors , 2005 .

[46]  Paul Watts,et al.  The application of micro reactors for organic synthesis. , 2005, Chemical Society reviews.

[47]  J. Hartwig,et al.  Aqueous hydroxide as a base for palladium-catalyzed amination of aryl chlorides and bromides. , 2002, The Journal of organic chemistry.

[48]  Klavs F Jensen,et al.  Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions. , 2007, Angewandte Chemie.

[49]  J. Verkade,et al.  Scope and limitations of Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides. , 2004, The Journal of organic chemistry.

[50]  R. SanMartin,et al.  Palladium and copper-catalysed arylation reactions in the presence of water, with a focus on carbon-heteroatom bond formation. , 2008, Chemical Society reviews.

[51]  C. Wiles,et al.  Synthesis of analytically pure compounds in flow reactors , 2007 .