Assessment of oral health status of children with Leukemia: A cross-sectional study.

AIM The present study was conducted with an aim to assess the oral hygiene status, gingival health status, and prevalence of dental caries, oral mucositis and xerostomia among children with leukemia and compare it with healthy children. METHODS AND RESULTS A total sample size of 220 children with 110 children with Leukemia of subtype acute lymphoblastic leukemia (ALL) undergoing treatment and 110 healthy children in the age group of 3-14 years was selected. Evaluation of caries status using dmft/DMFT indices, oral hygiene status using OHI-S and plaque index by Sillness and Loe, gingival health status using modified gingival index, oral mucositis as per WHO oral toxicity scale, xerostomia as per common terminology criteria for adverse events for dry mouth, and salivary pH using pH paper strips was done. Results revealed a lower prevalence of dental caries, good oral hygiene and mild gingivitis in children with ALL when compared to healthy children. Oral mucositis was found to occur only in children with ALL and a reduced salivary flow rate and reduced salivary pH were seen in these children when compared to healthy children. CONCLUSION It was concluded that children with ALL undergoing treatment and following an oral care protocol presented with a good Oral Health Status when compared with healthy children.

[1]  Priyakumari Thankamony,et al.  Infections during Induction Chemotherapy in Children with Acute Lymphoblastic Leukemia – Profile and Outcomes: Experience from a Cancer Center in South India , 2018, Indian Journal of Medical and Paediatric Oncology.

[2]  B. Dembowska-Baginska,et al.  Factors influencing caries incidence in permanent teeth in children/adolescents under and after anti-neoplastic treatment , 2016, Contemporary oncology.

[3]  Fareed,et al.  Oral Health Status in Jordanian Children with Cancer Undergoing Chemotherapy , 2016 .

[4]  U. Azher,et al.  Oral health status of children with acute lymphoblastic leukemia undergoing chemotherapy. , 2013, Indian journal of dental research : official publication of Indian Society for Dental Research.

[5]  E. Pels,et al.  Oral hygiene in children suffering from acute lymphoblastic leukemia living in rural and urban regions. , 2012, Annals of agricultural and environmental medicine : AAEM.

[6]  J. Dhillon,et al.  Oral Health in Children with Leukemia , 2012, Indian journal of palliative care.

[7]  S. Joshi,et al.  Evaluation of oral hygiene status, salivary characteristics and dental caries experience in acute lymphoblastic leukemic (ALL) children. , 2011, The Journal of clinical pediatric dentistry.

[8]  T. Eden,et al.  Epidemiology of childhood cancer in India. , 2009, Indian journal of cancer.

[9]  KL Girish Babu,et al.  Oral manifestations in acute lymphoblastic leukemic children under chemotherapy. , 2008, The Journal of clinical pediatric dentistry.

[10]  Christian Urban,et al.  Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. , 2007, Blood.

[11]  A. Hegde,et al.  Dental health status in children with acute lymphoblastic leukemia. , 2007, The Journal of clinical pediatric dentistry.

[12]  C Scully,et al.  An update of the etiology and management of xerostomia. , 2004, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[13]  B. Antmen,et al.  Oral Health Status in Children with Acute Lymphoblastic Leukemia and Lymphoma. , 2001, Turkish journal of haematology : official journal of Turkish Society of Haematology.

[14]  W. Kamps,et al.  Leukemia‐induced bone marrow depression: Effects of gangliosides on erythroid cell production , 1999, International journal of cancer.

[15]  C. Goho Chemoradiation therapy: effect on dental development. , 1993, Pediatric dentistry.

[16]  N. Ross,et al.  A modified gingival index for use in clinical trials. , 1986, Clinical preventive dentistry.

[17]  D. Fischer,et al.  Intracranial calcifications in childhood leukemia , 1977 .

[18]  R. Baehner,et al.  Oral manifestations of acute leukemia in children. , 1977, Journal of the American Dental Association.

[19]  R. Baehner,et al.  Management of acute leukemia. , 1973, Current problems in pediatrics.

[20]  G. E. White Oral manifestations of leukemia in children. , 1970, Oral surgery, oral medicine, and oral pathology.

[21]  I. Ship,et al.  Initial oral manifestations of leukemia. , 1967, Journal of the American Dental Association.

[22]  H. Löe,et al.  PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. , 1964, Acta odontologica Scandinavica.

[23]  J C GREENE,et al.  THE SIMPLIFIED ORAL HYGIENE INDEX. , 1964, Journal of the American Dental Association.