Fibroblast Growth Factor 23 and Klotho in AKI.

[1]  D. Leaf,et al.  Dysregulated Mineral Metabolism in AKI. , 2019, Seminars in nephrology.

[2]  C. Faul,et al.  FGF23 Actions on Target Tissues—With and Without Klotho , 2018, Front. Endocrinol..

[3]  Alvaro M. Gonzalez-Ibanez,et al.  Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury. , 2018, Kidney international.

[4]  S. Goldstein,et al.  Early postoperative measurement of fibroblast growth factor 23 predicts severe acute kidney injury in infants after cardiac surgery , 2018, Clinical nephrology.

[5]  D. Leaf,et al.  Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. , 2018, Clinical journal of the American Society of Nephrology : CJASN.

[6]  A. Rydzewska-Rosołowska,et al.  C‐terminal and intact FGF23 in critical illness and their associations with acute kidney injury and in‐hospital mortality , 2018, Cytokine.

[7]  Gurinder K. Singh,et al.  Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  M. Mohammadi,et al.  αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling , 2018, Nature.

[9]  G. Choukroun,et al.  Randomized Clinical Trial of Sevelamer Carbonate on Serum Klotho and Fibroblast Growth Factor 23 in CKD. , 2017, Clinical journal of the American Society of Nephrology : CJASN.

[10]  Edward R. Smith,et al.  FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction. , 2017, The international journal of biochemistry & cell biology.

[11]  M. Ivan,et al.  Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow , 2017, Haematologica.

[12]  M. van Meurs,et al.  Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease. , 2017, JCI insight.

[13]  Zhihong Liu,et al.  Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. , 2017, Kidney international.

[14]  P. Flevaris,et al.  PAI-1 is a critical regulator of FGF23 homeostasis , 2017, Science Advances.

[15]  Javier A. Neyra,et al.  Potential application of klotho in human chronic kidney disease. , 2017, Bone.

[16]  T. Sécher,et al.  Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia. , 2017, Kidney international.

[17]  Edward R. Smith,et al.  FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts , 2017, Scientific Reports.

[18]  Sherry L. Werner,et al.  Spleen contributes significantly to increased circulating levels of fibroblast growth factor 23 in response to lipopolysaccharide-induced inflammation , 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[19]  D. Leaf,et al.  Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. , 2017, Journal of the American Society of Nephrology : JASN.

[20]  W. Richards,et al.  Differential regulation of renal Klotho and FGFR1 in normal and uremic rats , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  M. Wolf,et al.  FGF23/FGFR4-mediated left ventricular hypertrophy is reversible , 2017, Scientific Reports.

[22]  K. White,et al.  Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels , 2017, Endocrinology.

[23]  Masaya Takahashi,et al.  Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy. , 2017, Kidney international.

[24]  E. Seibert,et al.  Serum klotho levels in acute kidney injury
. , 2017, Clinical nephrology.

[25]  Jun Yang,et al.  Activation of peroxisome proliferator-activated receptor γ inhibits vascular calcification by upregulating Klotho , 2016, Experimental and therapeutic medicine.

[26]  Sherry L. Werner,et al.  Spleen contributes significantly to increased circulating levels of fibroblast growth factor23 in response to lipopolysaccharide-induced inflammation. , 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[27]  J. Xie,et al.  Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes. , 2017, Journal of the American Society of Nephrology : JASN.

[28]  M. Wolf,et al.  Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. , 2016, Clinical journal of the American Society of Nephrology : CJASN.

[29]  M. Wolf,et al.  Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. , 2016, Kidney international.

[30]  Han Jun Cho,et al.  αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy. , 2016, Journal of the American Society of Nephrology : JASN.

[31]  A. Dusso,et al.  Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease. , 2016, Kidney International.

[32]  D. Leaf,et al.  Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. , 2016, Kidney International.

[33]  M. Unruh,et al.  FGF23 signaling impairs neutrophil recruitment and host defense during CKD. , 2016, The Journal of clinical investigation.

[34]  B. Kestenbaum,et al.  Renal Clearance of Mineral Metabolism Biomarkers. , 2016, Journal of the American Society of Nephrology : JASN.

[35]  J. Silver,et al.  The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. , 2016, American journal of physiology. Renal physiology.

[36]  Hyun Hee Lee,et al.  Klotho and S100A8/A9 as Discriminative Markers between Pre-Renal and Intrinsic Acute Kidney Injury , 2016, PloS one.

[37]  M. Accetturo,et al.  Complement Modulation of Anti‐Aging Factor Klotho in Ischemia/Reperfusion Injury and Delayed Graft Function , 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[38]  M. Wolf,et al.  Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production , 2015, Kidney international.

[39]  S. Sidhu,et al.  Renal Production, Uptake, and Handling of Circulating αKlotho. , 2016, Journal of the American Society of Nephrology : JASN.

[40]  M. C. Hu,et al.  αKlotho and Chronic Kidney Disease. , 2016, Vitamins and hormones.

[41]  M. Mace,et al.  Key role of the kidney in the regulation of fibroblast growth factor 23. , 2015, Kidney international.

[42]  P. He,et al.  RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation , 2015, Experimental biology and medicine.

[43]  M. Vervloet,et al.  α-Klotho is unstable in human urine. , 2015, Kidney international.

[44]  A. Ullrich,et al.  Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. , 2015, Cell metabolism.

[45]  I. Narita,et al.  Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency , 2015, Nephron.

[46]  Javier A. Neyra,et al.  Klotho, stem cells, and aging , 2015, Clinical interventions in aging.

[47]  N. Won,et al.  Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury , 2015, The Korean journal of internal medicine.

[48]  Han Jun Cho,et al.  Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. , 2015, Journal of the American Society of Nephrology : JASN.

[49]  Minying Chen,et al.  Klotho: a novel and early biomarker of acute kidney injury after cardiac valve replacement surgery in adults. , 2015, International journal of clinical and experimental medicine.

[50]  R. Erben,et al.  Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor‐23 , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  J. Xie,et al.  Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate. , 2015, Journal of the American Society of Nephrology : JASN.

[52]  F. Glorieux,et al.  Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23. , 2015, The Journal of clinical endocrinology and metabolism.

[53]  Jun Gu,et al.  Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy. , 2015, Journal of the American Society of Nephrology : JASN.

[54]  I. Torregrosa,et al.  Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography. , 2015, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

[55]  M. Mohammadi,et al.  The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[56]  Ting-ting Yang,et al.  Signals mediating Klotho-induced neuroprotection in hippocampal neuronal cells. , 2015, Acta neurobiologiae experimentalis.

[57]  D. Elashoff,et al.  Effects of acute kidney injury and chronic hypoxemia on fibroblast growth factor 23 levels in pediatric cardiac surgery patients , 2015, Pediatric Nephrology.

[58]  Youhua Liu,et al.  Klotho suppresses renal tubulo‐interstitial fibrosis by controlling basic fibroblast growth factor‐2 signalling , 2014, The Journal of pathology.

[59]  M. Kuro-o,et al.  α-Klotho protects against oxidative damage in pulmonary epithelia. , 2014, American journal of physiology. Lung cellular and molecular physiology.

[60]  M. Wacker,et al.  FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability. , 2014, American journal of physiology. Endocrinology and metabolism.

[61]  B. Turk,et al.  Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho , 2014, Biochemistry.

[62]  M. Wolf,et al.  Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease , 2014, Current opinion in nephrology and hypertension.

[63]  J. Guh,et al.  Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts , 2014, Molecular and Cellular Endocrinology.

[64]  A. Nishiyama,et al.  Calcitriol Supplementation Improves Endothelium-Dependent Vasodilation in Rat Hypertensive Renal Injury , 2014, Kidney and Blood Pressure Research.

[65]  M. Peacock,et al.  Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia. , 2014, The Journal of clinical investigation.

[66]  V. Nizet,et al.  Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis , 2014, Proceedings of the National Academy of Sciences.

[67]  S. Rivella,et al.  FGF-23 Is a Negative Regulator of Prenatal and Postnatal Erythropoiesis* , 2014, The Journal of Biological Chemistry.

[68]  Jeremiah R. Brown,et al.  Fibroblast growth factor-23 and the long-term risk of hospital-associated AKI among community-dwelling older individuals. , 2014, Clinical journal of the American Society of Nephrology : CJASN.

[69]  E. Farrow,et al.  Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[70]  B. Lanske,et al.  FGF23 promotes renal calcium reabsorption through the TRPV5 channel , 2014, The EMBO journal.

[71]  O. Moe,et al.  Klotho has dual protective effects on cisplatin-induced acute kidney injury , 2013, Kidney international.

[72]  B. Lanske,et al.  FGF23 regulates renal sodium handling and blood pressure , 2012, EMBO molecular medicine.

[73]  L. Gnudi,et al.  Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria. , 2013, Clinical journal of the American Society of Nephrology : CJASN.

[74]  D. Leaf,et al.  Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes , 2013, Clinical endocrinology.

[75]  G. Remuzzi,et al.  Renal Expression of FGF23 in Progressive Renal Disease of Diabetes and the Effect of Ace Inhibitor , 2013, PloS one.

[76]  M. Wolf,et al.  Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[77]  H. Jüppner,et al.  FGF23 and mineral metabolism in the early post-renal transplantation period , 2013, Pediatric Nephrology.

[78]  P. Aljama,et al.  The effect of phosphate binders, calcium and lanthanum carbonate on FGF23 levels in chronic kidney disease patients. , 2013, Clinical nephrology.

[79]  C. Elie,et al.  Plasma Fibroblast Growth Factor 23 Concentration Is Increased and Predicts Mortality in Patients on the Liver-Transplant Waiting List , 2013, PloS one.

[80]  Huiliang Xie,et al.  Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD. , 2013, Clinical journal of the American Society of Nephrology : CJASN.

[81]  D. Leaf,et al.  Plasma FGF23 levels increase rapidly after acute kidney injury , 2013, Kidney international.

[82]  Jianping Zhou,et al.  Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. , 2013, Human pathology.

[83]  Youhua Liu,et al.  Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling. , 2013, Journal of the American Society of Nephrology : JASN.

[84]  W. Xu,et al.  Klotho Sensitizes Human Lung Cancer Cell Line to Cisplatin via PI3k/Akt Pathway , 2013, PloS one.

[85]  D. Leaf,et al.  Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. , 2013, The Journal of clinical endocrinology and metabolism.

[86]  J. Bacchetta,et al.  Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25‐dihydroxyvitamin D in human monocytes , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[87]  C. Langman,et al.  Preoperative plasma FGF23 levels predict acute kidney injury in children: results of a pilot study , 2013, Pediatric Nephrology.

[88]  E. Farrow,et al.  Circulating αKlotho influences phosphate handling by controlling FGF23 production. , 2012, The Journal of clinical investigation.

[89]  Marc M. Takeno,et al.  Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet , 2012, Kidney international.

[90]  Herbert Chase,et al.  FGF-23 levels in patients with AKI and risk of adverse outcomes. , 2012, Clinical journal of the American Society of Nephrology : CJASN.

[91]  B. Kestenbaum,et al.  Effects of phosphate binders in moderate CKD. , 2012, Journal of the American Society of Nephrology : JASN.

[92]  Y. Furukawa,et al.  Promoter methylation confers kidney‐specific expression of the Klotho gene , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[93]  W. Richards,et al.  FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. , 2012, The Journal of clinical investigation.

[94]  Edward R. Smith,et al.  Biological variability of plasma intact and C-terminal FGF23 measurements. , 2012, The Journal of clinical endocrinology and metabolism.

[95]  M. Mitobe,et al.  Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis. , 2012, American journal of physiology. Renal physiology.

[96]  T. Isakova Fibroblast growth factor 23 and adverse clinical outcomes in chronic kidney disease , 2012, Current opinion in nephrology and hypertension.

[97]  V. Wu,et al.  KLOTHO methylation is linked to uremic toxins and chronic kidney disease. , 2012, Kidney international.

[98]  Shi-Chung Chang,et al.  Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation , 2012, Kidney international.

[99]  Jason R. Stubbs,et al.  Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[100]  M. Razzaque,et al.  FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies? , 2012, Advances in experimental medicine and biology.

[101]  M. Wolf,et al.  (1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers. , 2012, Clinical journal of the American Society of Nephrology : CJASN.

[102]  S. Bose,et al.  Epigenetic silencing of the tumor suppressor klotho in human breast cancer , 2012, Breast Cancer Research and Treatment.

[103]  A. Go,et al.  FGF23 induces left ventricular hypertrophy. , 2011, The Journal of clinical investigation.

[104]  E. Farrow,et al.  Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice , 2011, Proceedings of the National Academy of Sciences.

[105]  W. Sellers,et al.  FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF‐23 signaling and regulating FGF‐23 expression in bone , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[106]  Jian Q. Feng,et al.  Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[107]  M. Sánchez-Niño,et al.  The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. , 2011, Journal of the American Society of Nephrology : JASN.

[108]  Jiang He,et al.  Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. , 2011, JAMA.

[109]  Chi-yuan Hsu,et al.  FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study , 2011, Annals of intensive care.

[110]  H. Kobori,et al.  Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[111]  F. Liu,et al.  Klotho suppresses RIG-I-mediated senescence-associated inflammation , 2011, Nature Cell Biology.

[112]  O. Togao,et al.  Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice* , 2011, The Journal of Biological Chemistry.

[113]  M. Kuro-o,et al.  Klotho deficiency causes vascular calcification in chronic kidney disease. , 2011, Journal of the American Society of Nephrology : JASN.

[114]  M. Kuro-o,et al.  Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. , 2010, Kidney international.

[115]  K. Rosenblatt,et al.  Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[116]  D. Besselsen,et al.  Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. , 2010, Gastroenterology.

[117]  D. Leaf,et al.  Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. , 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[118]  M. Wolf,et al.  Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. , 2010, The Journal of clinical endocrinology and metabolism.

[119]  H. Jüppner,et al.  Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. , 2010, Annual review of medicine.

[120]  M. Razzaque,et al.  Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation , 2009, Proceedings of the National Academy of Sciences.

[121]  R. Pecoits-Filho,et al.  Left ventricular mass in chronic kidney disease and ESRD. , 2009, Clinical journal of the American Society of Nephrology : CJASN.

[122]  R. Pereira,et al.  Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. , 2009, Bone.

[123]  Li-jun Ma,et al.  The PPARgamma agonist pioglitazone ameliorates aging-related progressive renal injury. , 2009, Journal of the American Society of Nephrology : JASN.

[124]  P. Saftig,et al.  Klotho is a substrate for α‐, β‐ and γ‐secretase , 2009 .

[125]  M. Razzaque,et al.  Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. , 2009, Kidney international.

[126]  L. Quarles,et al.  FGFR3 and FGFR4 do not mediate renal effects of FGF23. , 2008, Journal of the American Society of Nephrology : JASN.

[127]  Jing Wu,et al.  Klotho is a target gene of PPAR-gamma. , 2008, Kidney international.

[128]  M. Wolf,et al.  Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. , 2008, The New England journal of medicine.

[129]  M. Kuro-o Klotho as a regulator of oxidative stress and senescence , 2008, Biological chemistry.

[130]  R. Kumar,et al.  Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. , 2008, The Journal of clinical investigation.

[131]  S. Leeman,et al.  Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 , 2007, Proceedings of the National Academy of Sciences.

[132]  L S Jefferson,et al.  Modified RIFLE criteria in critically ill children with acute kidney injury. , 2007, Kidney international.

[133]  John A Kellum,et al.  Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury , 2007, Critical care.

[134]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[135]  T. Strom,et al.  Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis , 2006, Journal of Biological Chemistry.

[136]  M. Mitobe,et al.  Klotho reduces apoptosis in experimental ischaemic acute renal failure. , 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[137]  K. White,et al.  Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. , 2005, Endocrinology.

[138]  M. Mitobe,et al.  Oxidative Stress Decreases Klotho Expression in a Mouse Kidney Cell Line , 2005, Nephron Experimental Nephrology.

[139]  P. Orlik,et al.  An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. , 2005, Human molecular genetics.

[140]  M. Razzaque,et al.  Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. , 2004, Matrix biology : journal of the International Society for Matrix Biology.

[141]  H. Matsubara,et al.  HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. , 2004, Cardiovascular research.

[142]  Charles E McCulloch,et al.  Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. , 2004, The New England journal of medicine.

[143]  Y. Takeuchi,et al.  Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. , 2004, The Journal of clinical investigation.

[144]  Y. Takeuchi,et al.  FGF‐23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[145]  K. White,et al.  Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. , 2003, The New England journal of medicine.

[146]  S. Takeda,et al.  Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[147]  T. Meitinger,et al.  Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 , 2000, Nature Genetics.

[148]  M. Kuro-o,et al.  Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1 , 1998, FEBS letters.

[149]  R. Nagai,et al.  Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. , 1998, Biochemical and biophysical research communications.

[150]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[151]  N. Yazaki,et al.  The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues. , 1993, Biochimica et biophysica acta.