Design and Characterization of a Tissue-Mimicking Phantom for Ultrasonic Elastography

Tissue-mimicking phantoms are essential for the investigation of ultrasonic elastography. A modified polyacrylamide gel based tissue-mimicking phantom is developed in this paper. It shows greater stability than phantom based on physical gel, such as gelatin and agar. The elastic and echographic properties of this phantom are determined by the concentration of acrylamide and graphite powder respectively. Both indentation testing and transient elastography are used to characterize the elastic properties of this phantom. The results are almost consistent with each other. Our work indicate that Young's modulus of the polyacrylamide gel based tissue-mimicking phantom is similar to that of human soft tissue, which ranged from several kilopascal to a few tens of kilopascal.

[1]  T. Krouskop,et al.  Phantom materials for elastography , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[2]  F. Kallel,et al.  A Least-Squares Strain Estimator for Elastography , 1997, Ultrasonic imaging.

[3]  M. Ziol,et al.  Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. , 2003, Ultrasound in medicine & biology.

[4]  M. Fink,et al.  Shear elasticity probe for soft tissues with 1-D transient elastography , 2002, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  M. Fink,et al.  Diffraction field of a low frequency vibrator in soft tissues using transient elastography , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  G. Pharr,et al.  An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments , 1992 .

[7]  J Bercoff,et al.  In vivo breast tumor detection using transient elastography. , 2003, Ultrasound in medicine & biology.

[8]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[9]  D. Stone,et al.  An investigation of hardness and adhesion of sputter-deposited aluminum on silicon by utilizing a continuous indentation test , 1988 .

[10]  Eugène Dieulesaint,et al.  Elastic Waves in Solids II , 2000 .

[11]  Jonathan Ophir,et al.  Comparing elastographic strain images with modulus images obtained using nanoindentation: preliminary results using phantoms and tissue samples. , 2004, Ultrasound in medicine & biology.

[12]  Stanislav Emelianov,et al.  Biophysical Bases of Elasticity Imaging , 1995 .

[13]  D. Royer,et al.  Elastic waves in solids , 1980 .

[14]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.