GAB2 induces tumor angiogenesis in NRAS-driven melanoma

[1]  A. Wozniak.  Challenges in the current antiangiogenic treatment paradigm for patients with non-small cell lung cancer. , 2012, Critical reviews in oncology/hematology.

[2]  P. Carmeliet,et al.  Molecular mechanisms and clinical applications of angiogenesis , 2011, Nature.

[3]  F. McCormick,et al.  Therapeutic strategies for targeting ras proteins. , 2011, Genes & cancer.

[4]  M. Shibuya,et al.  Grb-2–associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A–endothelial NOS pathway , 2011, Proceedings of the National Academy of Sciences.

[5]  J. Gershenwald,et al.  Staging and prognosis of cutaneous melanoma. , 2011, Surgical oncology clinics of North America.

[6]  G. Merlino,et al.  Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation , 2011, Oncogene.

[7]  Rong Wang,et al.  Glioblastoma stem-like cells give rise to tumour endothelium , 2010, Nature.

[8]  A. Jemal,et al.  Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.

[9]  J. Reis-Filho,et al.  Tumor and Stem Cell Biology Cancer Research A Mouse Model of Melanoma Driven by Oncogenic KRAS , 2010 .

[10]  J. Gershenwald,et al.  2010 TNM Staging System for Cutaneous Melanoma…and Beyond , 2010, Annals of Surgical Oncology.

[11]  S. Jeffrey,et al.  Focal amplification and oncogene dependency of GAB2 in breast cancer , 2010, Oncogene.

[12]  N. Dumaz,et al.  c-Kit mutants require hypoxia-inducible factor 1α to transform melanocytes , 2010, Oncogene.

[13]  Roger J Daly,et al.  Function, regulation and pathological roles of the Gab/DOS docking proteins , 2009, Cell Communication and Signaling.

[14]  D. Silvers,et al.  GAB2 Amplifications Refine Molecular Classification of Melanoma , 2009, Clinical Cancer Research.

[15]  Kathleen M Spring,et al.  Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. , 2009, Cellular signalling.

[16]  L. Chin,et al.  Genetics and genomics of melanoma. , 2009, Expert review of dermatology.

[17]  D. Rimm,et al.  Gab2-mediated signaling promotes melanoma metastasis. , 2009, The American journal of pathology.

[18]  R. DePinho,et al.  BRafV600E cooperates with Pten silencing to elicit metastatic melanoma , 2009, Nature Genetics.

[19]  L. Rönnstrand,et al.  Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit* , 2008, Journal of Biological Chemistry.

[20]  Holger Gerhardt,et al.  VEGF and endothelial guidance in angiogenic sprouting , 2008, Organogenesis.

[21]  Y. Funahashi,et al.  Notch signaling regulates tumor angiogenesis by diverse mechanisms , 2008, Oncogene.

[22]  C Blake Gilks,et al.  Amplification of 11q13 in ovarian carcinoma , 2008, Genes, chromosomes & cancer.

[23]  R. Daly,et al.  Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis , 2008, Oncogene.

[24]  G. Feng,et al.  Role of Gab2 in mammary tumorigenesis and metastasis , 2007, Oncogene.

[25]  R. DePinho,et al.  ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence , 2007, Proceedings of the National Academy of Sciences.

[26]  I. Amelio,et al.  Shp2 in PC12 cells: NGF versus EGF signalling. , 2007, Cellular signalling.

[27]  R. Stenne,et al.  The Scaffolding Adapter Gab1 Mediates Vascular Endothelial Growth Factor Signaling and Is Required for Endothelial Cell Migration and Capillary Formation* , 2007, Journal of Biological Chemistry.

[28]  R. Marais,et al.  Melanoma biology and new targeted therapy , 2007, Nature.

[29]  F. Speleman,et al.  GAB2 is a novel target of 11q amplification in AML/MDS , 2006, Genes, chromosomes & cancer.

[30]  J. Salles,et al.  The Adaptor Protein Gab1 Couples the Stimulation of Vascular Endothelial Growth Factor Receptor-2 to the Activation of Phosphoinositide 3-Kinase* , 2006, Journal of Biological Chemistry.

[31]  Soldano Ferrone,et al.  Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity. , 2006, Cancer research.

[32]  T. Takeuchi,et al.  Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast‐like cells and phosphorylation of Gab adapter proteins activated by platelet‐derived growth factor , 2006, Clinical and experimental immunology.

[33]  A. Jemal,et al.  Cancer Statistics, 2006 , 2006, CA: a cancer journal for clinicians.

[34]  Andrea Richardson,et al.  A role for the scaffolding adapter GAB2 in breast cancer , 2006, Nature Medicine.

[35]  Songshu Meng,et al.  Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. , 2005, The Biochemical journal.

[36]  Angel W. Lee,et al.  A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid–induced neuronal differentiation , 2005, The Journal of cell biology.

[37]  P. Khavari,et al.  Use of human tissue to assess the oncogenic activity of melanoma-associated mutations , 2005, Nature Genetics.

[38]  A. Trumpp,et al.  Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. , 2005, Cancer research.

[39]  D. Spandidos,et al.  Oncogenic Kinase Signaling in Human Neoplasms , 2004, Annals of the New York Academy of Sciences.

[40]  C. Springer,et al.  V599EB-RAF is an Oncogene in Melanocytes , 2004, Cancer Research.

[41]  E. Voest,et al.  Stimulation of angiogenesis by Ras proteins. , 2004, Biochimica et biophysica acta.

[42]  C. Berking,et al.  Induction of Melanoma Phenotypes in Human Skin by Growth Factors and Ultraviolet B , 2004, Cancer Research.

[43]  T. Hirano,et al.  The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors , 2003, Cancer science.

[44]  M. Hendrix,et al.  Angiogenesis: Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma , 2003, Nature Reviews Cancer.

[45]  B. Neel,et al.  The "Gab" in signal transduction. , 2003, Trends in cell biology.

[46]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[47]  H. Iwasaki,et al.  Critical role for Gab2 in transformation by BCR/ABL. , 2002, Cancer cell.

[48]  C. Maroun,et al.  Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. , 2002, Molecular biology of the cell.

[49]  L. Chin,et al.  Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas , 2001, Molecular and Cellular Biology.

[50]  J. C. Pratt,et al.  Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. , 1998, Molecular cell.

[51]  L. Chin,et al.  Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. , 1997, Genes & development.

[52]  J. Folkman,et al.  Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Bing Li,et al.  Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo , 1993, Nature.

[54]  D. Bennett,et al.  A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth , 1987, International journal of cancer.