Butyrylcholinesterase activity and risk factors for coronary artery disease

The aim of this study was to verify which risk factors for coronary artery disease (CAD) are independently correlated with butyrylcholinesterase (BChE) activity. We studied 88 White individuals (43 males) aged 47.3 - 15.7 years (mean - SD; range: 14.0 - 80.0 years) including 38 with hyperlipidemia, 30 with hypertension and 5 with diabetes mellitus (DM). Simple correlation analysis showed that BChE activity was positively correlated with age, sex, body mass index, hypertension and DM, as well as with triglycerides (TGs), total cholesterol, lowdensity lipoprotein cholesterol and apolipoprotein B (Apo B). However, after a step-wise multiple regression analysis, the only risk factors for CAD that showed independent correlations with BChE activity were, in descending order of importance, Apo B, TGs and DM. Our findings seem to reinforce suggested associations of BChE activity with lipoprotein synthesis and with hypertension, as well as supporting previous data on the relation of BChE activity with disturbances found in diabetes mellitus.

[1]  R. Evans,et al.  Is serum cholinesterase activity a predictor of succinyl choline sensitivity? An assessment of four methods. , 1978, Clinical chemistry.

[2]  A. Brock,et al.  Plasma cholinesterase activity in a healthy population group with no occupational exposure to known cholinesterase inhibitors: relative influence of some factors related to normal inter- and intra-individual variations. , 1990, Scandinavian journal of clinical and laboratory investigation.

[3]  M. Cucuianu,et al.  Pseudocholinesterase in obese and hyperlipemic subjects. , 1968, Clinica chimica acta; international journal of clinical chemistry.

[4]  B. Howard,et al.  Lipoprotein metabolism in diabetes mellitus. , 1987, Journal of lipid research.

[5]  A. Dietz,et al.  Correlation of Cholinesterase with Serum Lipids and Lipoproteins , 1987, Journal of clinical pharmacology.

[6]  A. Boulton,et al.  Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus. , 1993, Clinical science.

[7]  E. Alanen,et al.  Levels of serum lipids, apolipoproteins A-I and B and pseudocholinesterase activity and their discriminative values in patients with coronary by-pass operation. , 1986, Atherosclerosis.

[8]  E. Kunec-Vajić,et al.  Pseudocholinesterase in alloxan-diabetic rats. , 1992, Research communications in chemical pathology and pharmacology.

[9]  K. Kutty,et al.  Serum pseudocholinesterase and very‐low‐density lipoprotein metabolism , 1994, Journal of clinical laboratory analysis.

[10]  G. Picheth,et al.  The C5 isozyme of serum cholinesterase and adult weight. , 1991, Human heredity.

[11]  K. Kutty,et al.  Pseudocholinesterase/high-density lipoprotein cholesterol ratio in serum of normal persons and of hyperlipoproteinemics. , 1983, Clinical chemistry.

[12]  H. Sobotka,et al.  Choline-Esterase Activity of Human Sera, with Special Reference to Hyperthyroidism.∗ , 1937 .

[13]  M. Mitchard,et al.  The Possible Biological Function of Pseudo-cholinesterase , 1963, Nature.

[14]  A. Cox,et al.  Interrelationship between serum -lipoprotein and cholinesterase. , 1973, Canadian journal of biochemistry.

[15]  E. Reiner,et al.  Serum paraoxonase and cholinesterase activities in individuals with lipid and glucose metabolism disorders. , 1993, Chemico-biological interactions.

[16]  M. Crook,et al.  Serum lipids, acute phase proteins and serum cholinesterase in normal subjects. , 1994, Scandinavian journal of clinical and laboratory investigation.

[17]  E. Feldman,et al.  Lipids and lipoproteins , 1989 .

[18]  M. Cucuianu,et al.  Serum pseudocholinesterase and ceruloplasmin in various types of hyperlipoproteinemia. , 1975, Clinica chimica acta; international journal of clinical chemistry.

[19]  J. A. Lovern.  Lipids and Lipoproteins , 1960, Nature.

[20]  G. Picheth,et al.  An improved method for butyrylcholinesterase phenotyping , 1994, Biochemical Genetics.

[21]  J. Brunzell,et al.  Apoprotein measurements and their clinical application. , 1989, Clinics in laboratory medicine.

[22]  W. Castelli,et al.  Summary Estimates of Cholesterol Used to Predict Coronary Heart Disease , 1983, Circulation.

[23]  P. Fontaine,et al.  Cholinesterase in serum and low density lipoprotein of hyperlipidemic patients. , 1978, Clinica chimica acta; international journal of clinical chemistry.

[24]  J. Deslypere,et al.  Discriminative value of lipids and apoproteins in coronary heart disease. , 1982, Atherosclerosis.

[25]  A. Dietz,et al.  Colorimetric determination of serum cholinesterase and its genetic variants by the propionylthiocholine-dithiobis(nitrobenzoic acid)procedure. , 1973, Clinical chemistry.

[26]  K. Kutty,et al.  Serum pseudocholinesterase: high density lipoprotein cholesterol ratio as an index of risk for cardiovascular disease. , 1981, Clinica chimica acta; international journal of clinical chemistry.