Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
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L. Moore | S. Kliewer | D. D. Mckee | B. Goodwin | S A Kliewer | D D McKee | L B Moore | B Goodwin | C M Stoltz | C. Stoltz | D. D. McKee
[1] J. Pascussi,et al. Induction of CYP2C genes in human hepatocytes in primary culture. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[2] L. Lesko,et al. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes , 2000, Xenobiotica; the fate of foreign compounds in biological systems.
[3] D W Nebert,et al. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. , 1996, Pharmacogenetics.
[4] T. Willson,et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[5] D. Moore,et al. Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR* , 1997, The Journal of Biological Chemistry.
[6] A. Anderson,et al. Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene. , 1995, Gene.
[7] S. Ekins,et al. The role of CYP2B6 in human xenobiotic metabolism. , 1999, Drug metabolism reviews.
[8] M. Denison,et al. Xenobiotic-inducible Transcription of Cytochrome P450 Genes (*) , 1995, The Journal of Biological Chemistry.
[9] L. Moore,et al. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands* , 2000, The Journal of Biological Chemistry.
[10] T. Kawamoto,et al. Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene , 1999, Molecular and Cellular Biology.
[11] D. Waxman,et al. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. , 1999, Archives of biochemistry and biophysics.
[12] R Ohlsson,et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[13] B. Neuschwander‐Tetri,et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR , 2000, Nature.
[14] B. Goodwin,et al. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. , 1999, Molecular pharmacology.
[15] J. Lehmann,et al. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.
[16] T. Sueyoshi,et al. The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene , 1998, Molecular and Cellular Biology.
[17] J. Lehmann,et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.
[18] S. Safe,et al. Reciprocal Activation of Xenobiotic Response Genes by Nuclear Receptors Sxr/pxr and Car , 2000 .
[19] I. Phillips,et al. Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics* , 2001, The Journal of Biological Chemistry.
[20] D. Waxman,et al. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. , 1997, Cancer research.
[21] D. Moore,et al. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements , 1994, Molecular and cellular biology.
[22] S. Strom,et al. Use of human hepatocytes to study P450 gene induction. , 1996, Methods in enzymology.
[23] L. Moore,et al. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[24] Oliver Burk,et al. Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin* , 2001, The Journal of Biological Chemistry.
[25] D. Moore,et al. The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR , 2000, Molecular and Cellular Biology.
[26] L. Moore,et al. The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution , 2000 .
[27] Paavo Honkakoski,et al. The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene* , 1999, The Journal of Biological Chemistry.
[28] David D. Moore,et al. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β , 1998, Nature.
[29] D. Moore,et al. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism , 2000, Nature.
[30] W. Sabbagh,et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.
[31] P. Beaune,et al. Human CYP2B6: expression, inducibility and catalytic activities. , 1999, Pharmacogenetics.