IgA nephropathy associated with disseminated tuberculosis.

A 59-year-old man had disseminated tuberculosis and microscopic hematuria, red cell casts, and normal renal function. Renal biopsy revealed focal mesangial proliferation with exclusively IgA deposits, diagnostic of IgA nephropathy. After institution of antituberculous therapy, the urinary abnormalities resolved. There is evidence to suggest that tuberculosis, in addition to other conditions associated with mucosal exposure to antigens producing an IgA immune response, can result in IgA nephropathy. This glomerulopathy is reported as a potential renal complication of concurrent mycobacterial infection.

[1]  T. Whiteside,et al.  IgA-containing circulating immune complexes in patients with igA nephropathy. , 1983, The American journal of medicine.

[2]  J F Fries,et al.  The 1982 revised criteria for the classification of systemic lupus erythematosus. , 1982, Arthritis and rheumatism.

[3]  J. Jennette,et al.  IgA nephropathy associated with seronegative spondylarthropathies. , 1982, Arthritis and rheumatism.

[4]  M. Ishii,et al.  Mycoplasma pneumoniae pneumonia associated with IgA nephropathy. , 1982, Scandinavian journal of infectious diseases.

[5]  H. Helin,et al.  IgA nephropathy associated with bronchial small-cell carcinoma. , 1981, American journal of clinical pathology.

[6]  M. Mcnicol,et al.  Circulating immune complexes in tuberculosis. , 1981, Thorax.

[7]  J. Gillon,et al.  Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis. , 1980, The New England journal of medicine.

[8]  L. Trnka,et al.  Immunoprofile studies in patients with pulmonary tuberculosis. II. Correlation of levels of different classes of immunoglobulins and specific antibodies with the extent of tuberculosis. , 1979, Scandinavian journal of respiratory diseases.

[9]  H. Kida,et al.  Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: Clinicopathological and immunohistological characteristics. , 1978, The Quarterly journal of medicine.

[10]  J. L. Edwards,et al.  Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. , 1978, The American journal of medicine.

[11]  R. Bhatnagar,et al.  Spectrum of immune response abnormalities in different clinical forms of tuberculosis. , 1977, The American review of respiratory disease.

[12]  R. Sinniah,et al.  Lupus nephritis: correlation between light, electron microscopic and immunofluorescent findings and renal function. , 1976, Clinical nephrology.

[13]  A. Kennedy,et al.  Tuberculosis as a Continuing Cause of Renal Amyloidosis , 1974, British medical journal.

[14]  N. Rothfield,et al.  Patterns of nuclear fluorescence and DNA-binding activity. , 1973, Annals of the rheumatic diseases.

[15]  L. Berman,et al.  Glomerular abnormalities in tuberculosis. , 1960, Archives of pathology.

[16]  B. Ansell,et al.  Anaphylactoid Purpura in Pulmonary Tuberculosis , 1950, British medical journal.