Role of interleukin-1 in the depression of liver drug metabolism by endotoxin

Endotoxin-resistant C3H/HeJ mice were used to test the hypothesis that a macrophage product, possibly interleukin-1, might mediate the depression of liver cytochrome P-450-dependent drug metabolism in endotoxin-treated mice. Depression of liver drug metabolism by endotoxin was observed in normal mice (C3H/HeN) but not in C3H/HeJ mice. Serum transfer experiments demonstrated that a serum factor was responsible for the depression of liver drug metabolism. Experiments of passive transfer of peritoneal macrophages showed that this endotoxin-induced factor might be a macrophage product. In vitro experiments showed that endotoxin-stimulated monocytes produced a factor that depressed cytochrome P-450-dependent metabolism in cultured hepatocytes. Homogeneous human monocyte and recombinant interleukin-1 also depressed liver drug metabolism both in vivo and in vitro, suggesting that this macrophage product might be involved in the regulation of liver function by the immune system.

[1]  C. Dinarello,et al.  Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. , 1986, The Journal of clinical investigation.

[2]  H. Colten,et al.  Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1 , 1985, The Journal of experimental medicine.

[3]  P. Ghezzi,et al.  Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice. , 1985, Cancer research.

[4]  A. Mantovani,et al.  Prostacyclin synthesis induced in vascular cells by interleukin-1. , 1985, Science.

[5]  A. C. Webb,et al.  Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[6]  L. Griffeth,et al.  Effects of model traumatic injury on hepatic drug metabolism in the rat. I. In vivo antipyrine metabolism. , 1983, Drug metabolism and disposition: the biological fate of chemicals.

[7]  M. Huang,et al.  Effects of three recombinant human leukocyte interferons on drug metabolism in mice. , 1982, Drug metabolism and disposition: the biological fate of chemicals.

[8]  M. Skinner,et al.  THE ROLE OF INTERLEUKIN 1 IN ACUTE PHASE SERUM AMYLOID A (SAA) AND SERUM AMYLOID P (SAP) BIOSYNTHESIS * , 1982, Annals of the New York Academy of Sciences.

[9]  D. Rosenstreich,et al.  Defect in macrophage effector function confers Salmonella typhimurium susceptibility on C3H/HeJ mice. , 1982, Cellular immunology.

[10]  K. Renton,et al.  Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450. , 1980, Molecular pharmacology.

[11]  L. Pulliam,et al.  The activity of partially purified leukocytic endogenous mediator in endotoxin-resistant C3H/HeJ mice. , 1980, The Journal of laboratory and clinical medicine.

[12]  R. Fruncillo,et al.  Decreased aryl hydrocarbon hydroxylase after a 15% burn injury. , 1979, Biochemical pharmacology.

[13]  K. McAdam,et al.  Detection of a mediator derived from endotoxin-stimulated macrohpages that induces the acute phase serum amyloid A response in mice , 1979, The Journal of experimental medicine.

[14]  R. Fruncillo,et al.  Urinary excretion of D‐glucaric acid by severely burned patients , 1979, Clinical pharmacology and therapeutics.

[15]  A Poland,et al.  An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1978, The Journal of pharmacology and experimental therapeutics.

[16]  K. Goodrum,et al.  Elicitation of endotoxemic effects in C3H/HeJ mice with glucocorticoid antagonizing factor and partial characterization of the factor , 1978, Infection and immunity.

[17]  C. Dinarello,et al.  Human leukocytic pyrogen: purification and development of a radioimmunoassay. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Bissell,et al.  Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity. , 1976, Archives of biochemistry and biophysics.

[19]  J. Nolan,et al.  Hepatic microsomal drug metabolism after administration of endotoxin in rats. , 1976, Biochemical pharmacology.

[20]  B. Stock,et al.  Hepatic microsomal metabolism of drugs during pregnancy in the rat. , 1975, Drug metabolism and disposition: the biological fate of chemicals.

[21]  M. Ho.  Interferon-Like Viral Inhibitor in Rabbits after Intravenous Administration of Endotoxin , 1964, Science.

[22]  K. Renton,et al.  DEPRESSION OF HEPATIC CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEMS WITH ADMINISTERED INTERFERON INDUCING AGENTS , 1977 .

[23]  P. Seglen.  Preparation of isolated rat liver cells. , 1976, Methods in cell biology.