Examination of the retinal nerve fiber layer in the recognition of early glaucoma damage.

It and Direct correlations are made between retinal histology and the visible appearance of the retinal nerve fiber layer (NFL). An attempt is made to estimate the degree of damage to the NFL that must be present before it can be detected ophthalmo-scopically under ideal conditions (monkeys) and under actual clinical observations. In the monkey eyes, serial observations of the development and evolution of NFL atrophy are described in chronic experimental glaucoma for the first time. The accumulated observations of more than 3000 sets of NFL photographs in human glaucoma suspects and patients with visual field loss are used to present a practical set of findings to guide the clinician in the use of NFL examination for glaucoma management.

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