Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy

Purpose:  High‐frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast ripples (FRs) at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate marker for the localization of the epileptogenic zone. We evaluated the relationship of the resection of focal brain regions containing high‐rate interictal HFOs and the seizure‐onset zone (SOZ) determined by visual EEG analysis with the postsurgical seizure outcome, using extraoperative intracranial EEG monitoring in pediatric patients and automated HFO detection.

[1]  Otto Muzik,et al.  Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans. , 2008, Brain : a journal of neurology.

[2]  Charles L. Wilson,et al.  Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. , 2002, Journal of neurophysiology.

[3]  Charles L. Wilson,et al.  Hippocampal and Entorhinal Cortex High‐Frequency Oscillations (100–500 Hz) in Human Epileptic Brain and in Kainic Acid‐Treated Rats with Chronic Seizures , 1999, Epilepsia.

[4]  J. Gotman,et al.  High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type. , 2009, Brain : a journal of neurology.

[5]  J. Gotman,et al.  High‐frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery , 2010, Annals of neurology.

[6]  Jeffery A. Hall,et al.  Interictal high‐frequency oscillations (80–500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain , 2008, Epilepsia.

[7]  J. Gotman,et al.  Effect of sleep stage on interictal high‐frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy , 2009, Epilepsia.

[8]  Patient with Postcentral Gyrectomy Demonstrates Reliable Localization of Hand Motor Area Using Magnetoencephalography , 2009, Pediatric Neurosurgery.

[9]  Jean Gotman,et al.  Erratum: High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes (Epilepsia (2006) 47, (1465-1476)) , 2006 .

[10]  Jean Gotman,et al.  Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients. , 2007, Brain : a journal of neurology.

[11]  H. Lüders,et al.  Proposal for a New Classification of Outcome with Respect to Epileptic Seizures Following Epilepsy Surgery , 2001 .

[12]  Pierre LeVan,et al.  High‐Frequency Intracerebral EEG Activity (100–500 Hz) Following Interictal Spikes , 2006, Epilepsia.

[13]  Charles L. Wilson,et al.  High‐frequency oscillations recorded in human medial temporal lobe during sleep , 2004, Annals of neurology.

[14]  B. Litt,et al.  High-frequency oscillations and seizure generation in neocortical epilepsy. , 2004, Brain : a journal of neurology.

[15]  Ayako Ochi,et al.  High-frequency oscillations of ictal muscle activity and epileptogenic discharges on intracranial EEG in a temporal lobe epilepsy patient , 2008, Clinical Neurophysiology.

[16]  Jean Gotman,et al.  Improving the identification of High Frequency Oscillations , 2009, Clinical Neurophysiology.

[17]  C. Bénar,et al.  Pitfalls of high-pass filtering for detecting epileptic oscillations: A technical note on “false” ripples , 2010, Clinical Neurophysiology.

[18]  C. Schroeder,et al.  Spatial characterization of interictal high frequency oscillations in epileptic neocortex , 2009, Brain : a journal of neurology.

[19]  Brian Litt,et al.  Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings , 2007, Clinical Neurophysiology.

[20]  J. Martinerie,et al.  Mapping interictal oscillations greater than 200 Hz recorded with intracranial macroelectrodes in human epilepsy. , 2010, Brain : a journal of neurology.

[21]  Josef Kittler,et al.  Minimum error thresholding , 1986, Pattern Recognit..

[22]  Eishi Asano,et al.  Statistical mapping of ictal high‐frequency oscillations in epileptic spasms , 2011, Epilepsia.

[23]  J. Gotman,et al.  High-frequency oscillations during human focal seizures. , 2006, Brain : a journal of neurology.

[24]  Eishi Asano,et al.  Spontaneous and visually driven high‐frequency oscillations in the occipital cortex: Intracranial recording in epileptic patients , 2012, Human brain mapping.

[25]  Itzhak Fried,et al.  Interictal high‐frequency oscillations (80–500Hz) in the human epileptic brain: Entorhinal cortex , 2002, Annals of neurology.

[26]  G Curio,et al.  Localization of evoked neuromagnetic 600 Hz activity in the cerebral somatosensory system. , 1994, Electroencephalography and clinical neurophysiology.

[27]  I. Módy,et al.  High‐frequency oscillations: What is normal and what is not? , 2009, Epilepsia.

[28]  W T Blume,et al.  Proposal for a New Classification of Outcome with Respect to Epileptic Seizures Following Epilepsy Surgery , 2001, Epilepsia.

[29]  J. Drake,et al.  Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex. Clinical article. , 2009, Journal of neurosurgery. Pediatrics.

[30]  J Gotman,et al.  High-frequency oscillations mirror disease activity in patients with epilepsy , 2009, Neurology.

[31]  G. Mathern,et al.  Removing interictal fast ripples on electrocorticography linked with seizure freedom in children , 2010, Neurology.

[32]  Ayako Ochi,et al.  Dynamic Changes of Ictal High‐Frequency Oscillations in Neocortical Epilepsy: Using Multiple Band Frequency Analysis , 2007, Epilepsia.

[33]  J. Klimo.  Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex , 2010 .

[34]  Ayako Ochi,et al.  Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms , 2008, Epilepsy Research.