Optimal Control of Boolean Control Networks with Discounted Cost: An Efficient Approach based on Deterministic Markov Decision Process

This paper deals with the infinite-horizon optimal control problem for Boolean control networks (BCNs) with a discounted-cost criterion. This problem has been investigated in existing studies with algorithms characterized by high computational complexity. We thus attempt to develop more efficient approaches for this problem from a deterministic Markov decision process (DMDP) perspective. First, we show the eligibility of a DMDP to model the control process of a BCN and the existence of an optimal solution. Next, two approaches are developed to handle the optimal control problem in a DMDP. One approach adopts the well-known value iteration algorithm, and the other resorts to the Madani’s algorithm specifically designed for DMDPs. The latter approach can find an exact optimal solution and outperform existing methods in terms of time efficiency, while the former value iteration based approach usually obtains a near-optimal solution much faster than all others. The 9-state-4-input ara operon network of the bacteria E. coli is used to verify the effectiveness and performance of our approaches. Results show that both approaches can reduce the running time dramatically by several orders of magnitude compared with existing work.