Toward maintaining the genome: DNA damage and replication checkpoints.
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[1] B. Ponder,et al. The Genetics of Inherited Breast Cancer , 1998, Journal of Mammary Gland Biology and Neoplasia.
[2] J. Newport,et al. The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint* , 2002, The Journal of Biological Chemistry.
[3] M. Lopes,et al. Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects , 2002, Science.
[4] A. Carr,et al. Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. , 2002, Genes & development.
[5] S. Jackson,et al. The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling , 2002, Nature Reviews Molecular Cell Biology.
[6] S. Kron,et al. Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair. , 2002, Journal of cell science.
[7] P. Russell,et al. CDK Phosphorylation of Drc1 Regulates DNA Replication in Fission Yeast , 2002, Current Biology.
[8] John Rouse,et al. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. , 2002, Molecular cell.
[9] S. Elledge,et al. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. , 2002, Genetics.
[10] R. Kolodner,et al. Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[11] Rodney Rothstein,et al. The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[12] T. Okamoto,et al. Cdc25C interacts with PCNA at G2/M transition , 2002, Oncogene.
[13] Stéphanie Dutertre,et al. Dephosphorylation and Subcellular Compartment Change of the Mitotic Bloom's Syndrome DNA Helicase in Response to Ionizing Radiation* , 2002, The Journal of Biological Chemistry.
[14] Lawrence C. Brody,et al. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage , 2002, Nature Genetics.
[15] T. Enoch,et al. Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase. , 2002, Molecular Biology of the Cell.
[16] A. Fornace,et al. p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony. , 2002, Current opinion in genetics & development.
[17] G. Roeder,et al. A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. , 2002, Genes & development.
[18] H. Yoshida,et al. Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition , 2002, Nature Cell Biology.
[19] T. Pandita. ATM function and telomere stability , 2002, Oncogene.
[20] James K. Chen,et al. The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition , 2002, The Journal of cell biology.
[21] S. Elledge,et al. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. , 2002, Genes & development.
[22] T. Volkert,et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. , 2002, Genes & development.
[23] Junjie Chen,et al. A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival , 2002, Molecular and Cellular Biology.
[24] J. Manfredi,et al. Multiple roles of the tumor suppressor p53 , 2002, Current opinion in oncology.
[25] Junjie Chen,et al. Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress* , 2001, The Journal of Biological Chemistry.
[26] J. Bartek,et al. Mammalian G1- and S-phase checkpoints in response to DNA damage. , 2001, Current opinion in cell biology.
[27] G. Iliakis,et al. Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. , 2001, Cancer research.
[28] H. Klein. Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions. , 2001, Genetics.
[29] Jun Qin,et al. ATR and ATRIP: Partners in Checkpoint Signaling , 2001, Science.
[30] W. Dai,et al. Plk3 Functionally Links DNA Damage to Cell Cycle Arrest and Apoptosis at Least in Part via the p53 Pathway* , 2001, The Journal of Biological Chemistry.
[31] M. Itoh,et al. Involvement of the Interaction between p21 and Proliferating Cell Nuclear Antigen for the Maintenance of G2/M Arrest after DNA Damage* , 2001, The Journal of Biological Chemistry.
[32] G. Lucchini,et al. Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression , 2001, The EMBO journal.
[33] R. Medema,et al. Inhibition of Polo-like Kinase-1 by DNA Damage Occurs in an ATM- or ATR-dependent Fashion* , 2001, The Journal of Biological Chemistry.
[34] P. Russell,et al. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1 , 2001, Nature Cell Biology.
[35] I. Hickson,et al. Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint , 2001, Molecular and Cellular Biology.
[36] Stephen J. Elledge,et al. Mrc1 transduces signals of DNA replication stress to activate Rad53 , 2001, Nature Cell Biology.
[37] D. Toczyski,et al. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. , 2001, Genes & development.
[38] Kunihiro Matsumoto,et al. Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms , 2001, Science.
[39] H. Piwnica-Worms,et al. The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators* , 2001, The Journal of Biological Chemistry.
[40] Ronald W. Davis,et al. Replication dynamics of the yeast genome. , 2001, Science.
[41] D. Botstein,et al. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. , 2001, Molecular biology of the cell.
[42] J. Hurwitz,et al. Purification and characterization of human DNA damage checkpoint Rad complexes , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[43] R. Abraham. Cell cycle checkpoint signaling through the ATM and ATR kinases. , 2001, Genes & development.
[44] H. Pospiech,et al. BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response* , 2001, The Journal of Biological Chemistry.
[45] C. Newlon,et al. The DNA replication checkpoint response stabilizes stalled replication forks , 2001, Nature.
[46] J. Diffley,et al. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint , 2001, Nature.
[47] K. Khanna,et al. Chk2 Activation Dependence on Nbs1 after DNA Damage , 2001, Molecular and Cellular Biology.
[48] E. Eder,et al. On the role of alkylating mechanisms, O-alkylation and DNA-repair in genotoxicity and mutagenicity of alkylating methanesulfonates of widely varying structures in bacterial systems. , 2001, Chemico-biological interactions.
[49] A. Forrest,et al. Cdc25B activity is regulated by 14-3-3 , 2001, Oncogene.
[50] G. Lucchini,et al. The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes. , 2001, Genes & development.
[51] L. Karnitz,et al. Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex* , 2001, The Journal of Biological Chemistry.
[52] R. Rothstein,et al. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage , 2001, The EMBO journal.
[53] C. Gilbert,et al. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. , 2001, Molecular cell.
[54] J. Petrini,et al. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. , 2001, Molecular cell.
[55] G. Lucchini,et al. Characterization of mec1Kinase-Deficient Mutants and of New Hypomorphic mec1Alleles Impairing Subsets of the DNA Damage Response Pathway , 2001, Molecular and Cellular Biology.
[56] S. Brill,et al. Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae , 2001, Molecular and Cellular Biology.
[57] Yitzhak Hadar,et al. Initial Steps of Ferulic Acid Polymerization by Lignin Peroxidase* , 2001, The Journal of Biological Chemistry.
[58] S. Elledge,et al. Direct DNA binding by Brca1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[59] E. Appella,et al. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase , 2001, Nature.
[60] Bo Xu,et al. Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation , 2001, Molecular and Cellular Biology.
[61] K. Khanna,et al. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. , 2001, Molecular biology of the cell.
[62] N. Mailand,et al. The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis , 2001, Nature.
[63] P. Graves,et al. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding , 2001, Oncogene.
[64] G. Stark,et al. Regulation of the G2/M transition by p53 , 2001, Oncogene.
[65] W. L. Fangman,et al. An origin-deficient yeast artificial chromosome triggers a cell cycle checkpoint. , 2001, Molecular cell.
[66] A. Kumagai,et al. Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. , 2001, Molecular biology of the cell.
[67] N. Rhind,et al. Roles of the Mitotic Inhibitors Wee1 and Mik1 in the G2 DNA Damage and Replication Checkpoints , 2001, Molecular and Cellular Biology.
[68] K. Khanna,et al. DNA double-strand breaks: signaling, repair and the cancer connection , 2001, Nature Genetics.
[69] E. Foss. Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. , 2001, Genetics.
[70] Katsunori Sugimoto,et al. Pie1, a Protein Interacting with Mec1, Controls Cell Growth and Checkpoint Responses in Saccharomyces cerevisiae , 2001, Molecular and Cellular Biology.
[71] Y. Shiloh. ATM and ATR: networking cellular responses to DNA damage. , 2001, Current opinion in genetics & development.
[72] J. Haber,et al. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. , 2001, Molecular cell.
[73] P. Russell,et al. Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast , 2001, Current Biology.
[74] A. Amon. Focus on cell division , 2001, Nature Cell Biology.
[75] S. Powell,et al. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. , 2001, Cancer research.
[76] K. Cimprich,et al. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint , 2000, Current Biology.
[77] P. Russell,et al. Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1 , 2000, Molecular and Cellular Biology.
[78] S. Reed,et al. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. , 2000, Current opinion in cell biology.
[79] Masaaki Adachi,et al. p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation , 2000, The EMBO journal.
[80] S. Elledge,et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. , 2000, Genes & development.
[81] M. Kastan,et al. The many substrates and functions of ATM , 2000, Nature Reviews Molecular Cell Biology.
[82] N. Lowndes,et al. DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae , 2000, FEBS letters.
[83] A. Kumagai,et al. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. , 2000, Genes & development.
[84] S. Jackson,et al. LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae , 2000, The EMBO journal.
[85] T. Kelly,et al. Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response. , 2000, Nucleic acids research.
[86] R. Medema,et al. Polo-like kinase-1 is a target of the DNA damage checkpoint , 2000, Nature Cell Biology.
[87] J. Gautier,et al. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. , 2000, Molecular cell.
[88] M. Sternberg,et al. The BRCA1 C-terminal domain: structure and function. , 2000, Mutation research.
[89] G. Lucchini,et al. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. , 2000, Genes & development.
[90] R. Weichselbaum,et al. The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin* , 2000, The Journal of Biological Chemistry.
[91] Kunihiro Matsumoto,et al. Rfc5, in Cooperation with Rad24, Controls DNA Damage Checkpoints throughout the Cell Cycle inSaccharomyces cerevisiae , 2000, Molecular and Cellular Biology.
[92] G. Lucchini,et al. Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast. , 2000, Genetics.
[93] S. Gasser,et al. RecQ-like helicases: the DNA replication checkpoint connection. , 2000, Journal of cell science.
[94] T. Halazonetis,et al. Chfr defines a mitotic stress checkpoint that delays entry into metaphase , 2000, Nature.
[95] Y. Shiloh,et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response , 2000, Nature.
[96] Matthias Mann,et al. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres , 2000, Nature Genetics.
[97] Ceslovas Venclovas,et al. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes , 2000, Nucleic Acids Res..
[98] M. Falconi,et al. DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. , 2000, Mutation research.
[99] M. Gatei,et al. Role for ATM in DNA damage-induced phosphorylation of BRCA1. , 2000, Cancer research.
[100] W. Heyer,et al. DNA Repair Protein Rad55 Is a Terminal Substrate of the DNA Damage Checkpoints , 2000, Molecular and Cellular Biology.
[101] N. Mailand,et al. Rapid destruction of human Cdc25A in response to DNA damage. , 2000, Science.
[102] Y. Shiloh,et al. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products , 2000, Nature.
[103] S. Elledge,et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. , 2000, Genes & development.
[104] A. Carr,et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice , 2000, Current Biology.
[105] K. Khanna,et al. Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity* , 2000, The Journal of Biological Chemistry.
[106] Bo Xu,et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway , 2000, Nature.
[107] T. Petes,et al. Involvement of the Checkpoint Protein Mec1p in Silencing of Gene Expression at Telomeres in Saccharomyces cerevisiae , 2000, Molecular and Cellular Biology.
[108] H. Lieberman,et al. Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. , 2000, Genomics.
[109] F. J. Geske,et al. DNA repair is activated in early stages of p53-induced apoptosis , 2000, Cell Death and Differentiation.
[110] S. Elledge,et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. , 2000, Science.
[111] Antony M. Carr,et al. Piecing Together the p53 Puzzle , 2000, Science.
[112] Jong-Soo Lee,et al. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response , 2000, Nature.
[113] Yusuke Nakamura,et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage , 2000, Nature.
[114] Myron F. Goodman,et al. The importance of repairing stalled replication forks , 2000, Nature.
[115] J. Little,et al. Role and regulation of p53 during an ultraviolet radiation-induced G1 cell cycle arrest. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[116] S. Milstein,et al. A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans. , 2000, Molecular cell.
[117] D. Baltimore,et al. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. , 2000, Genes & development.
[118] T. Halazonetis,et al. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. , 2000, Genes & development.
[119] T. Caspari,et al. Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9 , 2000, Molecular and Cellular Biology.
[120] Y Taya,et al. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. , 2000, Genes & development.
[121] A. Shinohara,et al. The controlling role of ATM in homologous recombinational repair of DNA damage , 2000, The EMBO journal.
[122] J. Hodgkin,et al. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans , 2000, Nature.
[123] S. Gasser,et al. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. , 2000, Genes & development.
[124] N. Rhind,et al. Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint , 2000, Molecular biology of the cell.
[125] H. Erdjument-Bromage,et al. A novel Rad24 checkpoint protein complex closely related to replication factor C , 2000, Current Biology.
[126] K. Isselbacher,et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. , 1999, Science.
[127] Y. Shiloh,et al. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[128] B. Koller,et al. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene , 1999, Oncogene.
[129] A. Chabes,et al. Yeast Sml1, a Protein Inhibitor of Ribonucleotide Reductase* , 1999, The Journal of Biological Chemistry.
[130] D. Meek,et al. Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2 , 1999, The EMBO journal.
[131] T. Stankovic,et al. The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder , 1999, Cell.
[132] K. Tamai,et al. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. , 1999, Molecular biology of the cell.
[133] S. Elledge,et al. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. , 1999, Science.
[134] H. Wang,et al. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. , 1999, Science.
[135] G. Roeder,et al. The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28. , 1999, Molecular cell.
[136] G. Stark,et al. Mechanisms of G2 arrest in response to overexpression of p53. , 1999, Molecular biology of the cell.
[137] J. Petrini,et al. The Mre11-Rad50-Xrs2 Protein Complex Facilitates Homologous Recombination-Based Double-Strand Break Repair inSaccharomyces cerevisiae , 1999, Molecular and Cellular Biology.
[138] A. Carr,et al. A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins , 1999, Nature Cell Biology.
[139] Y. Shiloh,et al. ATM: A mediator of multiple responses to genotoxic stress , 1999, Oncogene.
[140] K. Kinzler,et al. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage , 1999, Nature.
[141] B. Koller,et al. Brca1 controls homology-directed DNA repair. , 1999, Molecular cell.
[142] B. Stillman,et al. Cdc7p–Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway , 1999, The EMBO journal.
[143] D. Thompson,et al. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. , 1999, Genetics.
[144] T. Weinert,et al. Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. , 1999, Genetics.
[145] B. Hann,et al. Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[146] J. Murray,et al. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p , 1999, Current Biology.
[147] M. Yanagida,et al. Cdc2 phosphorylation of Crb2 is required for reestablishing cell cycle progression after the damage checkpoint. , 1999, Molecular cell.
[148] A. Matsuura,et al. Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). , 1999, Genetics.
[149] D. Morgan,et al. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. , 1999, Genes & development.
[150] C. Wang,et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. , 1999, Science.
[151] H. Piwnica-Worms,et al. Overproduction of Human Myt1 Kinase Induces a G2 Cell Cycle Delay by Interfering with the Intracellular Trafficking of Cdc2-Cyclin B1 Complexes , 1999, Molecular and Cellular Biology.
[152] R. Jensen,et al. BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair* , 1999, The Journal of Biological Chemistry.
[153] James M. Roberts,et al. CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.
[154] R. S. St Onge,et al. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. , 1999, Molecular biology of the cell.
[155] T. Weinert,et al. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast , 1999, The EMBO journal.
[156] L. Guarente,et al. MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks , 1999, Cell.
[157] F. Zindy,et al. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. , 1999, Cancer research.
[158] R. Yarden,et al. BRCA1 interacts with components of the histone deacetylase complex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[159] H. Wang,et al. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[160] E. Gilson,et al. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions , 1999, Nature Genetics.
[161] L. Karnitz,et al. Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex* , 1999, The Journal of Biological Chemistry.
[162] S. Francesconi,et al. The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast. , 1999, Molecular & general genetics : MGG.
[163] C. Iftode,et al. Replication protein A (RPA): the eukaryotic SSB. , 1999, Critical reviews in biochemistry and molecular biology.
[164] T. Miyashita,et al. Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis , 1999, Nature Cell Biology.
[165] D. Morgan,et al. Pds 1 and Esp 1 control both anaphase and mitotic exit in normal cells and after DNA damage , 1999 .
[166] S. Francesconi,et al. The S / M checkpoint at 37°C and the recovery of viability of the mutant polδts3 require the crb2 +/rhp9 + gene in fission yeast , 1999, Molecular and General Genetics MGG.
[167] T. Petes,et al. Interactions of TLC 1 ( Which Encodes the RNA Subunit of Telomerase ) , TEL 1 , and MEC 1 in Regulating Telomere Length in the Yeast Saccharomyces cerevisiae , 1999 .
[168] W. Xiao,et al. Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. , 1999, Nucleic acids research.
[169] A. Carr,et al. Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses , 1998, The EMBO journal.
[170] S. Elledge,et al. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. , 1998, Science.
[171] Liang Cheng,et al. Cell Cycle Regulation of the Saccharomyces cerevisiae Polo-Like Kinase Cdc5p , 1998, Molecular and Cellular Biology.
[172] M. O'Connell,et al. Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast , 1998, Molecular and General Genetics MGG.
[173] J. Diffley,et al. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication , 1998, Nature.
[174] J. Vialard,et al. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1‐dependent hyperphosphorylation and interacts with Rad53 after DNA damage , 1998, The EMBO journal.
[175] S. Elledge,et al. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. , 1998, Genes & development.
[176] Y Taya,et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.
[177] L. Hartwell,et al. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. , 1998, Genetics.
[178] R Rothstein,et al. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. , 1998, Molecular cell.
[179] G. Chan,et al. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. , 1998, Molecular biology of the cell.
[180] B. Koller,et al. BRCA1 required for transcription-coupled repair of oxidative DNA damage. , 1998, Science.
[181] A. Emili,et al. MEC1-dependent phosphorylation of Rad9p in response to DNA damage. , 1998, Molecular cell.
[182] V. Noskov,et al. The RFC2 Gene, Encoding the Third-Largest Subunit of the Replication Factor C Complex, Is Required for an S-Phase Checkpoint in Saccharomyces cerevisiae , 1998, Molecular and Cellular Biology.
[183] A. Parker,et al. A Human Homologue of the Schizosaccharomyces pombe rad1 + Checkpoint Gene Encodes an Exonuclease* , 1998, The Journal of Biological Chemistry.
[184] A. Carr,et al. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[185] V. Yamazaki,et al. Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells. , 1998, Cancer research.
[186] D. Morgan,et al. Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage , 1998, The Journal of cell biology.
[187] E. Nishida,et al. Nuclear export of cyclin B1 and its possible role in the DNA damage‐induced G2 checkpoint , 1998, The EMBO journal.
[188] S. Davey,et al. Fission Yeast rad12+Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene , 1998, Molecular and Cellular Biology.
[189] John R Yates,et al. The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response , 1998, Cell.
[190] T. Weinert. DNA damage checkpoints update: getting molecular. , 1998, Current opinion in genetics & development.
[191] T. Bennett,et al. The Saccharomyces cerevisiae RAD9Checkpoint Reduces the DNA Damage-Associated Stimulation of Directed Translocations , 1998, Molecular and Cellular Biology.
[192] N. Walworth,et al. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. , 1998, Genes & development.
[193] Y Taya,et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.
[194] S. Jackson,et al. The DNA-dependent protein kinase , 1999 .
[195] M. Yanagida,et al. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. , 1997, Genes & development.
[196] K. Kinzler,et al. 14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression , 1997 .
[197] L. Breeden,et al. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. , 1997, Genes & development.
[198] B. Nelms,et al. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks , 1997, Molecular and cellular biology.
[199] S. Elledge,et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. , 1997, Science.
[200] C. Peng,et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. , 1997, Science.
[201] J. Willson,et al. Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint. , 1997, Nucleic acids research.
[202] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[203] G. Lucchini,et al. A role for DNA primase in coupling DNA replication to DNA damage response , 1997, The EMBO journal.
[204] E. Salmon,et al. Identification of a Mid-anaphase Checkpoint in Budding Yeast , 1997, The Journal of cell biology.
[205] Yonghong Xiao,et al. Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells , 1997, Cell.
[206] Y. Shiloh,et al. The genetic defect in ataxia-telangiectasia. , 1997, Annual review of immunology.
[207] Y. Shiloh,et al. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. , 1997, Annual review of genetics.
[208] P. Hieter,et al. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[209] Y. Nikolsky,et al. A meiotic recombination checkpoint controlled by mitotic checkpoint genes , 1996, Nature.
[210] S. Elledge,et al. RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. , 1996, Genes & development.
[211] D. Baltimore,et al. Dual roles of ATM in the cellular response to radiation and in cell growth control. , 1996, Genes & development.
[212] G. Lucchini,et al. The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast. , 1996, Nucleic acids research.
[213] J. Petrini,et al. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair , 1996, Molecular and cellular biology.
[214] K. Nakao,et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[215] R. Bernards,et al. rad-Dependent Response of the chk1-Encoded Protein Kinase at the DNA Damage Checkpoint , 1996, Science.
[216] G. Lucchini,et al. Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression. , 1995, Journal of molecular biology.
[217] S. Leem,et al. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[218] D. Lydall,et al. Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest , 1995, Science.
[219] A. Carr,et al. Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. , 1995, The EMBO journal.
[220] L. Hartwell,et al. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint , 1995, Molecular and cellular biology.
[221] L. Hartwell,et al. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage , 1995, Cell.
[222] M. Tatsuka,et al. Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation , 1995, Nature.
[223] M. Lovett,et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. , 1995, Science.
[224] G. Wahl,et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. , 1994, Genes & development.
[225] E. Friedberg,et al. Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents. , 1994, Genetics.
[226] L. Hartwell,et al. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. , 1994, Genes & development.
[227] A. Carr,et al. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. , 1994, Molecular biology of the cell.
[228] Virginia A. Zakian,et al. Loss of a yeast telomere: Arrest, recovery, and chromosome loss , 1993, Cell.
[229] S. Elledge,et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases , 1993, Cell.
[230] A. Carr,et al. Fission yeast genes involved in coupling mitosis to completion of DNA replication. , 1992, Genes & development.
[231] Hui Zhang,et al. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA , 1992, Cell.
[232] J. Haber,et al. Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation , 1992, Molecular and cellular biology.
[233] B. Vogelstein,et al. Participation of p53 protein in the cellular response to DNA damage. , 1991, Cancer research.
[234] L. Loeb,et al. Mutator phenotype may be required for multistage carcinogenesis. , 1991, Cancer research.
[235] B. Stillman,et al. Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis. , 1991, The Journal of biological chemistry.
[236] L. Hartwell,et al. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage , 1990, Molecular and cellular biology.
[237] L. Strong,et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.
[238] L. Hartwell,et al. Checkpoints: controls that ensure the order of cell cycle events. , 1989, Science.
[239] L. Hartwell,et al. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. , 1988, Science.
[240] J. Ward,et al. Biochemistry of DNA lesions. , 1985, Radiation research. Supplement.
[241] J. Whang‐Peng,et al. Chromosomal instability in ataxia telangiectasia. , 1982, Cancer genetics and cytogenetics.
[242] R. Painter,et al. Radiosensitivity in ataxia-telangiectasia: a new explanation. , 1980, Proceedings of the National Academy of Sciences of the United States of America.