A novel method for retinal exudate segmentation using signal separation algorithm

Diabetic retinopathy is one of the major causes of blindness in the world. Early diagnosis of this disease is vital to the prevention of visual loss. The analysis of retinal lesions such as exudates, microaneurysms and hemorrhages is a prerequisite to detect diabetic disorders such as diabetic retinopathy and macular edema in fundus images. This paper presents an automatic method for the detection of retinal exudates. The novelty of this method lies in the use of Morphological Component Analysis (MCA) algorithm to separate lesions from normal retinal structures to facilitate the detection process. In the first stage, vessels are separated from lesions using the MCA algorithm with appropriate dictionaries. Then, the lesion part of retinal image is prepared for the detection of exudate regions. The final exudate map is created using dynamic thresholding and mathematical morphologies. Performance of the proposed method is measured on the three publicly available DiaretDB, HEI-MED and e-ophtha datasets. Accordingly, the AUC of 0.961 and 0.948 and 0.937 is achieved respectively, which are greater than most of the state-of-the-art methods.

[1]  Jacques Wainer,et al.  Points of Interest and Visual Dictionaries for Automatic Retinal Lesion Detection , 2012, IEEE Transactions on Biomedical Engineering.

[2]  Shijian Lu,et al.  Accurate and Efficient Optic Disc Detection and Segmentation by a Circular Transformation , 2011, IEEE Transactions on Medical Imaging.

[3]  Wenwu Wang,et al.  Blind Source Separation: Advances in Theory, Algorithms and Applications , 2014 .

[4]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[5]  Xuelong Li,et al.  On Combining Morphological Component Analysis and Concentric Morphology Model for Mammographic Mass Detection , 2010, IEEE Transactions on Information Technology in Biomedicine.

[6]  Manuel João Oliveira Ferreira,et al.  Exudate segmentation in fundus images using an ant colony optimization approach , 2015, Inf. Sci..

[7]  Anam Tariq,et al.  Automated detection of exudates in colored retinal images for diagnosis of diabetic retinopathy. , 2012, Applied optics.

[8]  Michael Elad,et al.  Submitted to Ieee Transactions on Image Processing Image Decomposition via the Combination of Sparse Representations and a Variational Approach , 2022 .

[9]  C. Sinthanayothin,et al.  Automated detection of diabetic retinopathy on digital fundus images , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[10]  Joni-Kristian Kämäräinen,et al.  The DIARETDB1 Diabetic Retinopathy Database and Evaluation Protocol , 2007, BMVC.

[11]  Shehzad Khalid,et al.  Detection and classification of retinal lesions for grading of diabetic retinopathy , 2014, Comput. Biol. Medicine.

[12]  Roberto Hornero,et al.  Detection of Hard Exudates in Retinal Images Using a Radial Basis Function Classifier , 2009, Annals of Biomedical Engineering.

[13]  Gwénolé Quellec,et al.  Exudate detection in color retinal images for mass screening of diabetic retinopathy , 2014, Medical Image Anal..

[14]  Edward H. Adelson,et al.  The Laplacian Pyramid as a Compact Image Code , 1983, IEEE Trans. Commun..

[15]  Alireza Osareh,et al.  A Computational-Intelligence-Based Approach for Detection of Exudates in Diabetic Retinopathy Images , 2009, IEEE Transactions on Information Technology in Biomedicine.

[16]  D. Kavitha,et al.  Automatic detection of optic disc and exudates in retinal images , 2005, Proceedings of 2005 International Conference on Intelligent Sensing and Information Processing, 2005..

[17]  Bunyarit Uyyanonvara,et al.  Automatic exudate detection for diabetic retinopathy screening , 2009 .

[18]  Hamid Reza Pourreza,et al.  Fully automated diabetic retinopathy screening using morphological component analysis , 2015, Comput. Medical Imaging Graph..

[19]  Roberto Hornero,et al.  Retinal image analysis based on mixture models to detect hard exudates , 2009, Medical Image Anal..

[20]  P. Tseng,et al.  Block Coordinate Relaxation Methods for Nonparametric Wavelet Denoising , 2000 .

[21]  Minh N. Do,et al.  Ieee Transactions on Image Processing the Contourlet Transform: an Efficient Directional Multiresolution Image Representation , 2022 .

[22]  Jacob Scharcanski,et al.  A coarse-to-fine strategy for automatically detecting exudates in color eye fundus images , 2010, Comput. Medical Imaging Graph..

[23]  Huiqi Li,et al.  Automated feature extraction in color retinal images by a model based approach , 2004, IEEE Transactions on Biomedical Engineering.

[24]  B. van Ginneken,et al.  Automated detection and differentiation of drusen, exudates, and cotton-wool spots in digital color fundus photographs for diabetic retinopathy diagnosis. , 2007, Investigative ophthalmology & visual science.

[25]  Sharib Ali,et al.  Statistical atlas based exudate segmentation , 2013, Comput. Medical Imaging Graph..

[26]  J. Olson,et al.  Automated detection of exudates for diabetic retinopathy screening , 2007, Physics in medicine and biology.

[27]  András Hajdu,et al.  Automatic exudate detection by fusing multiple active contours and regionwise classification , 2014, Comput. Biol. Medicine.

[28]  S. Kumar,et al.  Automated lesion detectors in retinal fundus images , 2015, Comput. Biol. Medicine.

[29]  Ahmed Wasif Reza,et al.  Diagnosis of Diabetic Retinopathy: Automatic Extraction of Optic Disc and Exudates from Retinal Images using Marker-controlled Watershed Transformation , 2009, Journal of Medical Systems.

[30]  Bunyarit Uyyanonvara,et al.  Automatic detection of diabetic retinopathy exudates from non-dilated retinal images using mathematical morphology methods , 2008, Comput. Medical Imaging Graph..

[31]  Kenneth W. Tobin,et al.  Exudate-based diabetic macular edema detection in fundus images using publicly available datasets , 2012, Medical Image Anal..

[32]  R A Kirsch,et al.  Computer determination of the constituent structure of biological images. , 1971, Computers and biomedical research, an international journal.

[33]  Pascale Massin,et al.  A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina , 2002, IEEE Transactions on Medical Imaging.

[34]  Wang-Q Lim,et al.  Compactly Supported Shearlets , 2010, 1009.4359.

[35]  Xuelong Li,et al.  Image Quality Assessment Based on Multiscale Geometric Analysis , 2009, IEEE Transactions on Image Processing.

[36]  Hamid Reza Pourreza,et al.  Improvement of retinal blood vessel detection using morphological component analysis , 2015, Comput. Methods Programs Biomed..