Asthma and low level air pollution in Helsinki.

The effects of relatively low levels of air pollution and weather conditions on the number of patients who had asthma attacks and who were admitted to a hospital were studied in Helsinki during a 3-y period. The number of admissions increased during cold weather (n = 4,209), especially among persons who were of working age but not among children. Even after standardization for temperature, all admissions, including emergency ward admissions, were significantly correlated with ambient air concentrations of nitrogen dioxide (NO2), nitric oxide (NO), sulfur dioxide (SO2), carbon monoxide (CO), ozone (O3), and total suspended particulates (TSP). Regression analysis revealed that NO and O3 were most strongly associated with asthma problems. Effects of air pollutants and cold were maximal if they occurred on the same day, except for O3, which had a more pronounced effect after a 1-d lag. The associations between pollutants, low temperature, and admissions were most significant among adults of working age, followed by the elderly. Among children, only O3 and NO were significantly correlated with admissions. Levels of pollutants were fairly low, the long-term mean being 19.2 micrograms/m3 for SO2, 38.6 micrograms/m3 for NO2, 22.0 micrograms/m3 or O3, and 1.3 mg/m3 for CO. In contrast, the mean concentration of TSP was high (76.3 micrograms/m3), and the mean temperature was low (+ 4.7 degrees C). These results suggest that concentrations of pollutants lower than those given as guidelines in many countries may increase the incidence of asthma attacks.

[1]  H. Boushey,et al.  Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[2]  K. Weiss.  Seasonal trends in US asthma hospitalizations and mortality. , 1990, JAMA.

[3]  G. Asnani,et al.  The influence of weather on asthma in Nairobi , 1978, International journal of biometeorology.

[4]  G. Packe,et al.  ASTHMA OUTBREAK DURING A THUNDERSTORM , 1985, The Lancet.

[5]  I. Degroot,et al.  DETECTION OF ASTHMA EPIDEMICS IN SEVEN CITIES. , 1965, Archives of environmental health.

[6]  J. Charpin,et al.  Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients. , 1976, The Journal of clinical investigation.

[7]  I. Goldstein,et al.  Air pollution and asthma: effects of exposures to short-term sulfur dioxide peaks. , 1986, Environmental research.

[8]  W P D LOGAN,et al.  Mortality in the London fog incident, 1952. , 1953, Lancet.

[9]  F A Berciano,et al.  Influence of air pollution on extrinsic childhood asthma. , 1989, Annals of allergy.

[10]  A S Whittemore,et al.  Asthma and air pollution in the Los Angeles area. , 1980, American journal of public health.

[11]  S. Hellmann,et al.  Prevalence of respiratory symptoms and diseases in schoolchildren living in a polluted and in a low polluted area in Israel. , 1988, Environmental research.

[12]  N. Wilson.  Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. , 1982, The American review of respiratory disease.

[13]  M. Imai,et al.  Mortality from asthma and chronic bronchitis associated with changes in sulfur oxides air pollution. , 1986, Archives of environmental health.

[14]  C. W. Clarke.  Relationship of bacterial and viral infections to exacerbations of asthma. , 1979, Thorax.

[15]  M. Chapman,et al.  Seasonal variation in dust mite and grass-pollen allergens in dust from the houses of patients with asthma. , 1987, The Journal of allergy and clinical immunology.

[16]  A. Murray,et al.  The seasonal variation of allergic respiratory symptoms induced by house dust mites. , 1980, Annals of allergy.

[17]  H. Heimann,et al.  Air Pollution in Donora, Pa. Epidemiology of the Unusual Smog Episode of October 1948. Preliminary Report. , 1949 .

[18]  I. Goldstein,et al.  Seasonal patterns of asthma: a clue to etiology. , 1984, Environmental research.

[19]  L. Folinsbee,et al.  Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone with moderate exercise. , 1988, JAPCA.

[20]  J. Roca,et al.  ANOTHER ASTHMA OUTBREAK IN BARCELONA: ROLE OF OXIDES OF NITROGEN , 1984, The Lancet.

[21]  P. Morrow,et al.  Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. , 2015, The American review of respiratory disease.

[22]  S. Spector,et al.  Effects of particulate air pollution on asthmatics. , 1983, American journal of public health.

[23]  D V Bates,et al.  Asthma attack periodicity: a study of hospital emergency visits in Vancouver. , 1990, Environmental research.

[24]  H. Boushey,et al.  Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. , 2015, The American review of respiratory disease.

[25]  R. Rodríguez-Roisín,et al.  Community outbreaks of asthma associated with inhalation of soybean dust. Toxicoepidemiological Committee. , 1989, The New England journal of medicine.

[26]  W. Linn,et al.  Combined effect of sulfur dioxide and cold in exercising asthmatics. , 1984, Archives of environmental health.

[27]  R W Buechley,et al.  Asthma and air pollution from a coal-fueled power plant. , 1972, American journal of public health.

[28]  L Collins,et al.  Time series analyses of respiratory responses to indoor and outdoor environmental phenomena. , 1987, Environmental research.

[29]  M B Schenker,et al.  Daily air pollution effects on children's respiratory symptoms and peak expiratory flow. , 1987, American journal of public health.