Studies in the pathology and pathogenesis of experimental brucellosis. II. The formation of the hepatic granuloma and its evolution.

guinea pigs. In subsequent years, the occurrence of the granuloma of brucellosis has been reported in the tissues of mice by Feldman and Olson,2 of monkeys by Huddleson and Hallman,3 of dogs by Margolis et al,4 and of rats and rabbits by Nyka.5 Spink et al6 have observed granulomas in sections of liver obtained by biopsy from many patients having culturally proven brucellosis. Similar findings in sections of biopsied human bone marrow were reported by Sundberg and Spink.7 Although the uniform character of