Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down‐regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer. Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down‐regulated in ovarian cancers on gene expression arrays.

[1]  S Kobayashi,et al.  Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[2]  R. Bast,et al.  Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. , 2002, Cancer research.

[3]  R. Bast,et al.  Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. , 2003, Cancer research.

[4]  M. Oshimura,et al.  Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines. , 2004, DNA research : an international journal for rapid publication of reports on genes and genomes.

[5]  Ajay N. Jain,et al.  Expression of the Tumor Suppressor Gene ARHI in Epithelial Ovarian Cancer Is Associated with Increased Expression of p21WAF1/CIP1 and Prolonged Progression-Free Survival , 2004, Clinical Cancer Research.

[6]  H. Yoshioka,et al.  Epigenetic silencing of PEG3 gene expression in human glioma cell lines * , 2001, Molecular carcinogenesis.

[7]  R. Bast,et al.  Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. , 2003, Human molecular genetics.

[8]  Mark D. Johnson,et al.  Peg3/Pw1 Is a Mediator between p53 and Bax in DNA Damage-induced Neuronal Death* , 2002, The Journal of Biological Chemistry.

[9]  M. Surani,et al.  Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis , 1984, Nature.

[10]  A. Feinberg,et al.  Cancer epigenetics takes center stage. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J W Gray,et al.  NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[12]  David I. Smith,et al.  Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization. , 2002, Cancer research.

[13]  Anne Bergmann,et al.  Methylation-sensitive binding of transcription factor YY1 to an insulator sequence within the paternally expressed imprinted gene, Peg3. , 2003, Human molecular genetics.

[14]  Gordon B Mills,et al.  Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon , 2005, Clinical Cancer Research.

[15]  L. Ashworth,et al.  The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. , 1997, Genome research.

[16]  Xin Hu,et al.  Correlation between CpG methylation profiles and hormone receptor status in breast cancers , 2007, Breast Cancer Research.

[17]  R. Bast,et al.  Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer. , 1993, Journal of the National Cancer Institute.

[18]  R. Bast,et al.  Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[19]  M. Seoud,et al.  Maternal alleles acquiring paternal methylation patterns in biparental complete hydatidiform moles. , 2003, Human molecular genetics.

[20]  D. Bowtell,et al.  Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Bast,et al.  Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer , 2006, Clinical Cancer Research.

[22]  J. Gray,et al.  ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers , 2000, International journal of cancer.