Disposable filter for microemboli. Use in cardiopulmonary bypass and massive transfusion.

A disposable, autoclavable filter passes blood at high rates of flow without excessive hemolysis. It is constructed of polypropylene, except for the filter mesh which is made of a polyester material with a pore size of about 25μ The mean rise in the plasma hemoglobin level after four hours of recirculation of banked blood at 4 liters/min in a closed circuit in which the filter was employed was 75 mge100 cc. Studies during cardiopulmonary bypass have shown that much particulate matter can be filtered from the perfusate which otherwise would be returned as emboli to the patient. The filter can reduce or eliminate pulmonary insufficiency which sometimes results from massive transfusion of banked blood during hemorrhagic shock.

[1]  R. Patterson,et al.  Cerebral blood flow and metabolism during cardiopulmonary bypass , 1971, Neurology.

[2]  J. Mcnamara,et al.  Screen filtration pressure in combat casualties. , 1970, Annals of surgery.

[3]  H. Tufo,et al.  Central nervous system dysfunction following open-heart surgery. , 1970, JAMA.

[4]  D. Doty,et al.  Death Associated with Multiple Pulmonary Emboli Soon after Battle Injury , 1970, Annals of surgery.

[5]  D. Doty,et al.  Changes in the Filtration Characteristics of Stored Blood , 1970, Annals of surgery.

[6]  R. Patterson,et al.  The production of microemboli by various blood oxygenators. , 1970, The Annals of thoracic surgery.

[7]  R. Patterson,et al.  Microemboli during cardiopulmonary bypass detected by ultrasound. , 1969, Surgery, gynecology & obstetrics.

[8]  J. Hill,et al.  Neuropathological manifestations of cardiac surgery. , 1969, The Annals of thoracic surgery.

[9]  F. Belzer,et al.  Etiology of Rising Perfusion Pressure in Isolated Organ Perfusion , 1968, Annals of surgery.

[10]  R. Swank.  Platelet aggregation: its role and cause in surgical shock. , 1968, The Journal of trauma.

[11]  P. Ashmore,et al.  The importance of microembolism in the pathogenesis of organ dysfunction caused by prolonged use of the pump oxygenator. , 1966, The Journal of thoracic and cardiovascular surgery.

[12]  R. O. Brandenburg.  MEDICAL PROBLEMS OF AORTIC VALVE REPLACEMENT. , 1965, Progress in cardiovascular diseases.

[13]  D. Weiss,et al.  PLATELET MICROEMBOLI ASSOCIATED WITH MASSIVE BLOOD TRANSFUSION. , 1964, The American journal of pathology.

[14]  J. Wellington,et al.  EMBOLI ASSOCIATED WITH CARDIOPULMONARY BYPASS. , 1964, The Journal of thoracic and cardiovascular surgery.

[15]  R. Walter,et al.  Open-Heart Surgery: Neurologic Findings and Electroencephalographic Patterns Before, During, and After Open-Heart Surgery (Two-Year Follow-Up) , 1962 .

[16]  E. Fonkalsrud,et al.  Denaturation of plasma proteins as a cause of morbidity and death after intracardiac operations. , 1961, Surgery.

[17]  J. Ehrenhaft,et al.  Cerebral complications of open-heart surgery. , 1961, The Journal of thoracic and cardiovascular surgery.