MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells

Besides MDR1/P‐glycoprotein (MDR1/P‐gp), glucosylceramide synthase (GCS), an enzyme, which transfers UDP–glucose to ceramide to form glucosylceramide was also related with multidrug resistance (MDR) in breast cancer. Although many research showed that GCS could affect mdr1 in cancer cells, nobody knows that whether mdr1 can affect GCS in breast cancer. Our study aims to verify that.

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