Letter to the Editor: A Mechanism for Valproate-Induced Hyperammonemia

highly significant inhibition of citrullinogenesis in the presence of ary to an inhibition of the mitochondrial NAGA synthesis. In this succinate but not in the presence of glutamate. In the presence of way, N-carbamyl-glutamate which seems to cross freely the bioATP, oligomycin, and 2,4-dinitrophenol, the citrullinogenesis was logic membranes and activates CPS-1 (9) might be useful in the increased, but there was always a significant inhibition in val- management of patients with these valproate adverse effects. proate-treated rats. Concomitantly, there was a significant decrease of mitochondria1 N -acetylglutarnate (NAGA) level in valREFERENCES AND NOTES

[1]  W. Paik,et al.  Ammonia intoxication in rats: protection by N-carbamoyl-L-glutamate plus L-arginine. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[2]  G. H. Hogeboom.  [3] Fractionation of cell components of animal tissues , 1955 .