Tramadol / Dexketoprofen ( TRAM / DKP ) oral fixed dose combination is superior to tramadol / paracetamol in moderate-to-severe acute pain :

• Users may freely distribute the URL that is used to identify this publication. • Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. • User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (?) • Users may not further distribute the material nor use it for the purposes of commercial gain.

[1]  G. Varrassi,et al.  Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol , 2017, Current medical research and opinion.

[2]  Tess E. Cooper,et al.  Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. , 2016, The Cochrane database of systematic reviews.

[3]  J. Kotarski,et al.  Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy , 2016, BMC Anesthesiology.

[4]  R. Moore,et al.  Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty , 2015, British journal of anaesthesia.

[5]  C. Maggi,et al.  Pharmacokinetics of Dexketoprofen and tramadol given in combination: an open-label, randomized, 3-period crossover study in Healthy subjects , 2015 .

[6]  P. Coulthard,et al.  Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain , 2015, The Journal of Headache and Pain.

[7]  Yong Yue,et al.  Efficacy and speed of onset of pain relief of fast-dissolving paracetamol on postsurgical dental pain: two randomized, single-dose, double-blind, placebo-controlled clinical studies. , 2013, Clinical therapeutics.

[8]  S. Cooper,et al.  Evaluation of onset of pain relief from micronized aspirin in a dental pain model , 2012, Inflammopharmacology.

[9]  C. Pasero Persistent postsurgical and posttrauma pain. , 2011, Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.

[10]  P. Langley,et al.  The societal impact of pain in the European Union: health-related quality of life and healthcare resource utilization , 2010, Journal of medical economics.

[11]  S. Alahuhta,et al.  Effects of combination treatment with ketoprofen 100 mg + acetaminophen 1000 mg on postoperative dental pain: a single-dose, 10-hour, randomized, double-blind, active- and placebo-controlled clinical trial. , 2009, Clinical therapeutics.

[12]  M. Rodríguez,et al.  Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller. , 2008, Expert review of neurotherapeutics.

[13]  A. Stubhaug,et al.  Assessment of pain. , 2008, British journal of anaesthesia.

[14]  J. Ioannidis,et al.  Indirect comparisons: the mesh and mess of clinical trials , 2006, The Lancet.

[15]  D. Aronoff,et al.  New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases , 2006, Clinical pharmacology and therapeutics.

[16]  Girish P Joshi,et al.  Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. , 2005, Anesthesiology clinics of North America.

[17]  G. Graham,et al.  Mechanism of Action of Paracetamol , 2005, American journal of therapeutics.

[18]  R. Moore,et al.  Pain and analgesic response after third molar extraction and other postsurgical pain , 2004, Pain.

[19]  D. Shen,et al.  Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen , 2002, European Journal of Clinical Pharmacology.

[20]  S. Talwalker,et al.  The analgesic efficacy of valdecoxib vs. oxycodone/acetaminophen after oral surgery. , 2002, Journal of the American Dental Association.

[21]  M. McGurk,et al.  Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain. , 1998, Journal of clinical pharmacology.

[22]  F. R.,et al.  Review of head-to-head study designs in rheumatoid arthritis. , 2016, Seminars in arthritis and rheumatism.

[23]  K. Lehmann,et al.  Tramadol for the Management of Acute Pain , 2012, Drugs.

[24]  R. Moore,et al.  Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. , 2009, The Cochrane database of systematic reviews.

[25]  S. Grond,et al.  Clinical Pharmacology of Tramadol , 2004, Clinical pharmacokinetics.