Effects of combined exercise (aerobic + resistance) on the expression of miR-301a and some indicators of motor function in women with multiple sclerosis (MS)

Background & Objective: Several evidence has indicated the effective role of exercise on Multiple sclerosis (MS) patients. An aberrant expression of some Micro-RNAs such as increasing miR-301a in MS, with an impact on inflammatory pathways leading to the creation of inflammation in these patients. The purpose of this study was to investigate the effect of a combined eight-week (aerobic and resistance) exercise on expression of miR -301a and some indicators of motor function in women with multiple sclerosis. Materials & Methods: A total of 22 women with MS, who were randomly divided into experimental and control groups, participated in this study. The experimental group performed 8 weeks (4 days per week) of combined training. Expression of miR -301a was measured before and after the training period using Real-Time PCR method. Pre- and post-intervention scores of tests (TUG), (6MWT), (10 – MWT) and status scale (EDSS) were independent t-test recorded and analyzed. Results : The results of this study showed, the expression of miR -301a was significantly different between the two groups (P = 0.001). Tests TUG (P = 0.001), 6MWT (P = 0.002) and degree of disability EDSS (P = 0.015), were significantly different between the two groups. There was no significant difference between the 10MWT test between the two group (P = 0.678). Conclusion: The combined exercise for women with MS have been beneficial and improve motor function and reduce the expression of miR-301a. So, do it, plays an important role in reducing inflammation and prevent the progression of the disease Ms.

[1]  C. Javierre,et al.  Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. , 2018, Journal of sports science & medicine.

[2]  M. Khademosharie,et al.  Effect of 12-week Endurance-resistance Training on Motor and Muscular Function, Degree of Disability, Fatigue, and Quality of Life in Multiple Sclerosis Patients , 2018 .

[3]  U. Wisløff,et al.  MicroRNAs as Important Regulators of Exercise Adaptation. , 2017, Progress in cardiovascular diseases.

[4]  K. Shimizu,et al.  Ageing and free-living daily physical activity effects on salivary beta-defensin 2 secretion , 2017, Journal of sports sciences.

[5]  R. Curi,et al.  Regulation of Gene Expression by Exercise-Related Micrornas , 2016, Cellular Physiology and Biochemistry.

[6]  D. Hamar,et al.  Circulating MicroRNAs as Potential Biomarkers of Exercise Response , 2016, International journal of molecular sciences.

[7]  B. Sangelaji,et al.  A combined exercise model for improving muscle strength, balance, walking distance, and motor agility in multiple sclerosis patients: A randomized clinical trial , 2016, Iranian journal of neurology.

[8]  K. O'Halloran,et al.  Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology , 2016, Front. Physiol..

[9]  T. Olsson,et al.  High-intensity resistance training in multiple sclerosis — An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition , 2016, Journal of the Neurological Sciences.

[10]  G. Murugaiyan,et al.  Contribution of MicroRNAs to autoimmune diseases , 2016, Cellular and Molecular Life Sciences.

[11]  H. Goossens,et al.  12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis , 2016, Mediators of inflammation.

[12]  D. Hansen,et al.  Impact of 24 Weeks of Resistance and Endurance Exercise on Glucose Tolerance in Persons with Multiple Sclerosis , 2015, American journal of physical medicine & rehabilitation.

[13]  You Li,et al.  Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population , 2015, Cellular Physiology and Biochemistry.

[14]  Fatemeh Shahneh,et al.  Interleukin-17 in human inflammatory diseases , 2014, Postepy dermatologii i alergologii.

[15]  Baojun Zhang,et al.  miR-17-92 Cluster Targets Phosphatase and Tensin Homology and Ikaros Family Zinc Finger 4 to Promote TH17-mediated Inflammation* , 2014, The Journal of Biological Chemistry.

[16]  C. Watson,et al.  The Stat3 paradox: A killer and an oncogene , 2014, Molecular and Cellular Endocrinology.

[17]  M. Etemadifar,et al.  Epidemiology of Multiple Sclerosis in Iran: A Systematic Review , 2013, European Neurology.

[18]  A. Russell,et al.  Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short‐term endurance training , 2013, The Journal of physiology.

[19]  T. Ushida,et al.  Profiling of Circulating MicroRNAs after a Bout of Acute Resistance Exercise in Humans , 2013, PloS one.

[20]  Soyoung Lee,et al.  Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation , 2013, Proceedings of the National Academy of Sciences.

[21]  M. Maes,et al.  Exercising the worry away: How inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours , 2013, Neuroscience & Biobehavioral Reviews.

[22]  C. Vonarbourg,et al.  Aryl hydrocarbon receptor , 2012, Gut microbes.

[23]  Carlo Pozzilli,et al.  Assessing walking disability in multiple sclerosis , 2012, Multiple sclerosis.

[24]  K. Selmaj,et al.  microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination , 2012, Proceedings of the National Academy of Sciences.

[25]  H. Weiner,et al.  Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis , 2011, The Journal of Immunology.

[26]  Geert Alders,et al.  Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis , 2011, Multiple sclerosis.

[27]  Paul C. LaStayo,et al.  Effects of High-Intensity Resistance Training on Strength, Mobility, Balance, and Fatigue in Individuals With Multiple Sclerosis: A Randomized Controlled Trial , 2011, Journal of neurologic physical therapy : JNPT.

[28]  M. Kordi,et al.  Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis. , 2010, International immunopharmacology.

[29]  C. Schéele,et al.  Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle , 2010, The Journal of physiology.

[30]  D. Cooper,et al.  Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes. , 2010, Journal of applied physiology.

[31]  H. Erdem,et al.  Cycling Progressive Resistance Training for People with Multiple Sclerosis: A Randomized Controlled Study , 2010, American journal of physical medicine & rehabilitation.

[32]  H. J. Hansen,et al.  Fatigue, mood and quality of life improve in MS patients after progressive resistance training , 2010, Multiple sclerosis.

[33]  AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION , 2009, American journal of physical medicine & rehabilitation.

[34]  Shigetoshi Sano,et al.  Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. , 2008, Journal of dermatological science.

[35]  T. Ingemann-Hansen,et al.  Review: Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training , 2008, Multiple sclerosis.

[36]  M. Wiggins,et al.  Exercise Benefits for Multiple Sclerosis Participant: Case Study , 2007 .

[37]  L. White,et al.  Cytokine responses to resistance training in people with multiple sclerosis , 2006, Journal of sports sciences.

[38]  J. Burridge,et al.  Treadmill training for individuals with multiple sclerosis: a pilot randomised trial , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[39]  John W Chow,et al.  Resistance training improves gait kinematics in persons with multiple sclerosis. , 2005, Archives of physical medicine and rehabilitation.

[40]  A Ashburn,et al.  A pilot study of the effect of aerobic exercise on people with moderate disability multiple sclerosis , 2005, Clinical rehabilitation.

[41]  L. White,et al.  Cytokine Levels After Eight Weeks of Progressive Resistance Training in Multiple Sclerosis Patients , 2004 .

[42]  P. Thoumie,et al.  Relation between walking speed and muscle strength is affected by somatosensory loss in multiple sclerosis , 2002, Journal of neurology, neurosurgery, and psychiatry.

[43]  H. Hartung,et al.  New concepts in the immunopathogenesis of multiple sclerosis , 2002, Nature Reviews Neuroscience.

[44]  Roland Martin,et al.  The immunopathogenesis of multiple sclerosis. , 2002, Journal of rehabilitation research and development.

[45]  Peter Schjerling,et al.  Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans , 1999, The Journal of physiology.

[46]  P. Thompson,et al.  ACSM's Guidelines for Exercise Testing and Prescription , 1995 .

[47]  J A Ponichtera-Mulcare,et al.  Exercise and multiple sclerosis. , 1993, Medicine and science in sports and exercise.

[48]  T. Fog,et al.  [Multiple sclerosis; review]. , 1954, Maanedsskrift for praktisk laegegerning og social Medicin.

[49]  A. Khosravi,et al.  Association of disability with urinary and sexual dysfunction in patients with multiple sclerosis , 2018 .

[50]  S. Hemati,et al.  Effect of Six Weeks of Continuous Running on Oxidative Stress, Lipid Peroxidation and Aerobic Power in Female Survivors of Breast Cancer , 2017 .

[51]  A. Shaban,et al.  THE EFFECT OF ENDURANCE TRAINING ON MIR-155 EXPRESSION, STAT3 GENE EXPRESSION, AND INTERLEUKIN 6 PROTEIN IN MICE WITH BREAST CANCER , 2015 .

[52]  M. Hecker,et al.  MicroRNAs in multiple sclerosis and experimental autoimmune encephalomyelitis. , 2012, Autoimmunity reviews.