High prevalence of infectious events in thrombotic thrombocytopenic purpura and genetic relationship with toll‐like receptor 9 polymorphisms: experience of the French Thrombotic Microangiopathies Reference Center

Infectious events have been reported as major environmental triggers of thrombotic thrombocytopenic purpura (TTP). We detail here the potential association between infections and TTP.

[1]  B. Lämmle,et al.  Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. , 2012, Blood.

[2]  Matthew T. McBee,et al.  Seasonal association of thrombotic thrombocytopenic purpura , 2012, Transfusion.

[3]  I. Scharrer,et al.  The role of human leukocyte antigens as predisposing and/or protective factors in patients with idiopathic thrombotic thrombocytopenic purpura , 2012, Annals of Hematology.

[4]  M. Matsumoto,et al.  Acquired Idiopathic ADAMTS13 Activity Deficient Thrombotic Thrombocytopenic Purpura in a Population from Japan , 2012, PloS one.

[5]  C. T. Ammollo,et al.  Sepsis, thrombosis and organ dysfunction. , 2012, Thrombosis research.

[6]  W. Junger,et al.  Bacterial DNA Induces Pulmonary Damage Via TLR-9 Through Cross-talk With Neutrophils , 2011, Shock.

[7]  S. Vesely,et al.  Systemic infections mimicking thrombotic thrombocytopenic purpura , 2011, American journal of hematology.

[8]  Eric Rondeau,et al.  Predictive Features of Severe Acquired ADAMTS13 Deficiency in Idiopathic Thrombotic Microangiopathies: The French TMA Reference Center Experience , 2010, PloS one.

[9]  Charles B Cairns,et al.  Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[10]  É. Azoulay,et al.  HLA‐DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency‐related idiopathic thrombotic thrombocytopenic purpura in Caucasians , 2010, Journal of thrombosis and haemostasis : JTH.

[11]  S. Vesely,et al.  Survival and relapse in patients with thrombotic thrombocytopenic purpura. , 2010, Blood.

[12]  M. Scully,et al.  Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link , 2010, Journal of thrombosis and haemostasis : JTH.

[13]  D. Young,et al.  Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors: A single‐institution experience , 2010, Journal of clinical apheresis.

[14]  W. Junger,et al.  Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury , 2009, Nature.

[15]  J. Filep,et al.  Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling1 , 2009, The Journal of Immunology.

[16]  Ian Mackie,et al.  Regional UK TTP Registry: correlation with laboratory ADAMTS 13 analysis and clinical features , 2008, British journal of haematology.

[17]  S. Vesely,et al.  Sporadic bloody diarrhoea‐associated thrombotic thrombocytopenic purpura‐haemolytic uraemic syndrome: an adult and paediatric comparison , 2008, British journal of haematology.

[18]  W. Wiersinga,et al.  Inflammation, endothelium, and coagulation in sepsis , 2008, Journal of leukocyte biology.

[19]  O. Illoh.  Infection as a cause of early relapse in patients recovering from thrombotic thrombocytopenic purpura , 2007, Journal of clinical apheresis.

[20]  É. Oksenhendler,et al.  Prognostic value of anti-ADAMTS 13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS 13 activity. , 2007, Blood.

[21]  S. Landaw,et al.  Do infections provoke exacerbations and relapses of thrombotic thrombocytopenic purpura? , 2007, Journal of clinical apheresis.

[22]  S. Vesely,et al.  Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome , 2006, Transfusion.

[23]  A. Chauhan,et al.  Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. , 2005, The Journal of clinical investigation.

[24]  K. Lassoued,et al.  Severe ADAMTS13 Deficiency in Adult Idiopathic Thrombotic Microangiopathies Defines a Subset of Patients Characterized by Various Autoimmune Manifestations, Lower Platelet Count, and Mild Renal Involvement , 2004, Medicine.

[25]  S. Vesely,et al.  Severe deficiency of VWF‐cleaving protease (ADAMTS13) activity defines a distinct population of thrombotic microangiopathy patients , 2004, Transfusion.

[26]  Peter Donnelly,et al.  A comparison of bayesian methods for haplotype reconstruction from population genotype data. , 2003, American journal of human genetics.

[27]  É. Oksenhendler,et al.  Infectious diseases as a trigger in thrombotic microangiopathies in intensive care unit (ICU) patients? , 2003, Intensive Care Medicine.

[28]  A. Houllier,et al.  Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases. , 2001, Blood.

[29]  P. Donnelly,et al.  A new statistical method for haplotype reconstruction from population data. , 2001, American journal of human genetics.

[30]  B. Beutler,et al.  Three novel mammalian toll-like receptors: gene structure, expression, and evolution. , 2000, European cytokine network.

[31]  S. Vesely,et al.  Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura‐hemolytic‐uremic syndrome , 2000 .

[32]  M. Brecher,et al.  Thrombotic thrombocytopenic purpura that is refractory to therapeutic plasma exchange in two patients with occult infection , 1998, Transfusion.

[33]  M. Brecher,et al.  Thrombotic thrombocytopenic purpura and urinary tract infections: is there a connection? , 2011, American journal of clinical pathology.