The effect of age on the nerve fiber population of the human optic nerve.

Nerve fiber counts of 16 normal human optic nerves from subjects aged 3.5 to 82 years showed a significant effect of age (P = .0207). The delay between death or enucleation and fixation also significantly affected the result (P = .0078). The mean (+/- S.E.M.) count for the 16 nerves was 1,244,005 +/- 20,033 fibers, giving a 99% confidence level between 1,192,400 and 1,295,610 fibers.

[1]  H BRODY,et al.  Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex , 1955, The Journal of comparative neurology.

[2]  H. Quigley,et al.  Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage. , 1980, Archives of ophthalmology.

[3]  Bernard E. Tomlinson,et al.  Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer , 1980, Journal of the Neurological Sciences.

[4]  W. Green,et al.  Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. , 1982, Archives of ophthalmology.

[5]  B. Bengtsson.  THE ALTERATION AND ASYMMETRY OF CUP AND DISC DIAMETERS , 1980, Acta ophthalmologica.

[6]  A. Mccormick,et al.  Aging of the optic nerve. , 1980, Archives of ophthalmology.

[7]  C. B. Shelman,et al.  Morphology of the primate optic nerve. I. Method and total fiber count. , 1972, Investigative ophthalmology.

[8]  R D Monagle,et al.  The effects of age upon the main nucleus of the inferior olive in the human , 1974, The Journal of comparative neurology.

[9]  S. R. Bruesch,et al.  The number of myelinated and unmyelinated fibers in the optic nerve of vertebrates , 1942 .

[10]  E. Murphy,et al.  VOLUME OF THE VENTRAL COCHLEAR NUCLEUS IN MAN: ITS RELATIONSHIP TO NEURONAL POPULATION AND AGE , 1972, Journal of neuropathology and experimental neurology.

[11]  M. Motolko,et al.  The early psychophysical disturbances in chronic open-angle glaucoma. A study of visual functions with asymmetric disc cupping. , 1982, Archives of ophthalmology.

[12]  A. Sommer,et al.  The nerve fiber layer in the diagnosis of glaucoma. , 1977, Archives of ophthalmology.

[13]  C. Mcculloch,et al.  Assessment of the normal disc. , 1972, Transactions of the American Ophthalmological Society.

[14]  R. Massof,et al.  Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. , 1983, American journal of ophthalmology.

[15]  D. R. Anderson,et al.  The mode of progressive disc cupping in ocular hypertension and glaucoma. , 1980, Archives of ophthalmology.