Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence.

The inability of schizophrenics to filter irrelevant information has often been implicated in the psychopathology of schizophrenia. Despite numerous attempts at characterizing the behavior of schizophrenics in the presence of distractors, evidence of increased distractibility has been equivocal due to the difficulty of assessing simultaneously the behavioral and neurophysiological effects of distracting stimuli. We report the results of an experiment in which event-related potential and performance measures were used to assess distractibility during reaction time tasks under different distracting conditions. The results supported the view of an increased distractibility in schizophrenic patients. Event-related potential data suggested that in schizophrenic patients, a reduced amount of processing resources is allocated to process external stimuli and attention is abnormally apportioned to task-irrelevant vs task-relevant stimuli.

[1]  E. John,et al.  Evoked-Potential Correlates of Stimulus Uncertainty , 1965, Science.

[2]  T W Picton,et al.  N2 and automatic versus controlled processes. , 1986, Electroencephalography and clinical neurophysiology. Supplement.

[3]  A. Mcghie,et al.  Distractibility in Schizophrenia and Organic Cerebral Disease , 1967, British Journal of Psychiatry.

[4]  W. Pritchard.  Psychophysiology of P300. , 1981, Psychological bulletin.

[5]  J. Ford,et al.  Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. , 1984, Electroencephalography and clinical neurophysiology.

[6]  Sentence perception and distractibility in schizophrenic, manic, and depressed patients. , 1980, Journal of abnormal psychology.

[7]  D. V. van Kammen,et al.  Cerebrospinal fluid studies of monoamine metabolism in schizophrenia. , 1986, The Psychiatric clinics of North America.

[8]  J. Endicott,et al.  [Schedule for Affective Disorders and Schizophrenia (SADS)]. , 1987, Acta psychiatrica Belgica.

[9]  A. Starr,et al.  Endogenous late positive component of the evoked potential in cats corresponding to P300 in humans. , 1981, Science.

[10]  N. Swerdlow,et al.  Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics , 1986, Biological Psychiatry.

[11]  R Freedman,et al.  Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. , 1982, Biological psychiatry.

[12]  R. Steffy,et al.  Time-linked impairment in schizophrenic reaction time performance. , 1975, Journal of abnormal psychology.

[13]  M. Geyer,et al.  Prestimulus effects on human startle reflex in normals and schizophrenics. , 1978, Psychophysiology.

[14]  G. McCarthy,et al.  Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. , 1977, Science.

[15]  W. Roth,et al.  Some features of the auditory evoked response in schizophrenics. , 1972, Archives of general psychiatry.

[16]  R Galambos,et al.  Autism: processing of novel auditory information assessed by event-related brain potentials. , 1984, Electroencephalography and clinical neurophysiology.

[17]  K. Nuechterlein,et al.  Information processing and attentional functioning in the developmental course of schizophrenic disorders. , 1984, Schizophrenia bulletin.

[18]  B Renault,et al.  Onset and offset of brain events as indices of mental chronometry. , 1982, Science.

[19]  T. Oltmanns.  Selective attention in schizophrenic and manic psychoses: the effect of distraction on information processing. , 1978, Journal of abnormal psychology.

[20]  W. E. Broen.  Schizophrenia; research and theory , 1968 .

[21]  P. Venables,et al.  INPUT DYSFUNCTION IN SCHIZOPHRENIA. , 1964, Progress in experimental personality research.

[22]  H. Begleiter,et al.  Late positive component amplitude in schizophrenics and alcoholics in two different paradigms , 1987, Biological Psychiatry.

[23]  F. Rösler,et al.  Endogenous ERP components and cognitive constructs. A review. , 1986, Electroencephalography and clinical neurophysiology. Supplement.

[24]  S. Foote,et al.  Auditory event-related potentials in the squirrel monkey: Parallels to human late wave responses , 1984, Brain Research.

[25]  H. Begleiter,et al.  Event-related brain potentials to high-incentive stimuli in unmedicated schizophrenic patients. , 1983, Biological psychiatry.

[26]  S. J. Schneider.  Selective attention in schizophrenia. , 1976, Journal of abnormal psychology.

[27]  A. Öhman.  Electrodermal activity and vulnerability to schizophrenia: A review , 1981, Biological Psychology.

[28]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[29]  L. J. Chapman,et al.  The measurement of differential deficit. , 1978, Journal of psychiatric research.

[30]  C. Shagass,et al.  The attention-related somatosensory evoked potential late positive wave in psychiatric patients , 1981, Psychiatry Research.

[31]  J J Tecce,et al.  Contingent negative variation and the distraction--arousal hypothesis. , 1976, Electroencephalography and clinical neurophysiology.

[32]  S. Foote,et al.  Extrathalamic modulation of cortical function. , 1987, Annual review of neuroscience.

[33]  E. Courchesne.  15 Cognitive Components of the Event-Related Brain Potential: Changes Associated with Development , 1983 .

[34]  N. Squires,et al.  Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. , 1975, Electroencephalography and clinical neurophysiology.

[35]  R. Klorman,et al.  The late positive component of the evoked response in acute schizophrenics during a test of sustained attention. , 1980, Biological psychiatry.

[36]  Reduced range of sensory sensitivity in chronic nonparanoid schizophrenics. , 1972, Journal of abnormal psychology.

[37]  E Courchesne,et al.  Event-related brain potentials: comparison between children and adults. , 1977, Science.

[38]  W. Roth,et al.  ERPs and Psychopathology I. Behavioral Process Issues a , 1984, Annals of the New York Academy of Sciences.

[39]  Steven A. Hillyard,et al.  The effect of stimulus deviation on P3 waves to easily recognized stimuli , 1978, Neuropsychologia.

[40]  B S Kopell,et al.  Auditory evoked potentials to unpredictable shifts in pitch. , 1976, Psychophysiology.

[41]  T. Oltmanns,et al.  Schizophrenic performance when distractors are present: attentional deficit or differential task difficulty? , 1975, Journal of abnormal psychology.

[42]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[43]  A Pfefferbaum,et al.  Event-related potentials in schizophrenics. , 1980, Electroencephalography and clinical neurophysiology.

[44]  T. Oltmanns,et al.  The effect of anti-psychotic medication and diagnostic criteria on distractibility in schizophrenia. , 1978, Journal of psychiatric research.

[45]  E R John,et al.  Information Delivery and the Sensory Evoked Potential , 1967, Science.

[46]  S Sutton,et al.  Evoked potential correlates of information processing in psychiatric patients , 1973, Psychological Medicine.

[47]  O. Hornykiewicz.  Brain catecholamines in schizophrenia — a good case for noradrenaline , 1982, Nature.

[48]  W. Roth,et al.  Auditory evoked responses to unpredictable stimuli. , 1973, Psychophysiology.

[49]  E Callaway,et al.  Very short-term memory dysfunction in schizophrenia. Defective short time constant information processing in schizophrenia. , 1977, Archives of general psychiatry.

[50]  T. Picton,et al.  Schizophrenia: a neurophysiological evaluation of abnormal information processing. , 1983, Science.

[51]  E. Robins,et al.  Research diagnostic criteria: rationale and reliability. , 1978, Archives of general psychiatry.

[52]  W. Roth,et al.  P300—An Orienting Reaction in the Human Auditory Evoked Response , 1973, Perceptual and motor skills.

[53]  D Friedman,et al.  A brain event related to the making of a sensory discrimination. , 1979, Science.

[54]  B S Kopell,et al.  Effects of Stimulus Sequence on P300 and Reaction Time in Schizophrenics , 1984, Annals of the New York Academy of Sciences.

[55]  M. Geyer,et al.  Startle habituation and sensorimotor gating in schizophrenia and related animal models. , 1987, Schizophrenia bulletin.

[56]  E Courchesne,et al.  Changes in P3 waves with event repetition: long-term effects on scalp distribution and amplitude. , 1978, Electroencephalography and clinical neurophysiology.

[57]  J. Fleiss,et al.  The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. , 1976, Archives of general psychiatry.

[58]  H Begleiter,et al.  The N2 component of the event-related potential in schizophrenic patients. , 1987, Electroencephalography and clinical neurophysiology.