The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
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[1] D. St Johnston,et al. LKB1 and AMPK maintain epithelial cell polarity under energetic stress , 2013, The Journal of cell biology.
[2] S. Gamblin,et al. AMP-activated protein kinase: also regulated by ADP? , 2011, Trends in biochemical sciences.
[3] Clemens Diwoky,et al. Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia , 2011, Science.
[4] B. Kemp,et al. AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase , 2011, Science.
[5] M. Birnbaum,et al. ADaPting to Energetic Stress , 2011, Science.
[6] G. Shulman,et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. , 2011, Cell metabolism.
[7] B. Faubert,et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. , 2011, Genes & development.
[8] John B. Thomas,et al. A Hormone-Dependent Module Regulating Energy Balance , 2011, Cell.
[9] R. Evans,et al. Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.
[10] Chawnshang Chang,et al. Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity , 2011, Diabetes.
[11] P. Rakic,et al. AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization , 2011, Science.
[12] Vincent Mirouse,et al. The LKB1/AMPK polarity pathway , 2011, FEBS letters.
[13] Mengwei Zang,et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.
[14] B. Viollet,et al. AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner , 2011, PloS one.
[15] B. Viollet,et al. AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress , 2011, Proceedings of the National Academy of Sciences.
[16] David Carling,et al. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. , 2011, The Biochemical journal.
[17] David Carling,et al. Structure of Mammalian AMPK and its regulation by ADP , 2011, Nature.
[18] Xiaodong Wang,et al. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK , 2011, Proceedings of the National Academy of Sciences.
[19] R. Lifton,et al. AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane*♦ , 2011, The Journal of Biological Chemistry.
[20] M. Montminy,et al. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals , 2011, Nature Reviews Molecular Cell Biology.
[21] G. Manning,et al. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB , 2011, Nature.
[22] D. Hardie. AMPK and autophagy get connected , 2011, The EMBO journal.
[23] B. Viollet,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.
[24] B. Viollet,et al. Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.
[25] R. Moran,et al. Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. , 2010, Cancer research.
[26] Joseph S. Takahashi,et al. Circadian Integration of Metabolism and Energetics , 2010, Science.
[27] J. Girard,et al. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. , 2010, The Journal of clinical investigation.
[28] Hong-Gang Wang,et al. The Association of AMPK with ULK1 Regulates Autophagy , 2010, PloS one.
[29] Gerd Walz,et al. Primary cilia regulate mTORC1 activity and cell size through Lkb1 , 2010, Nature Cell Biology.
[30] S. Morrison,et al. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells , 2010, Nature.
[31] B. Kemp,et al. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) , 2010, Proceedings of the National Academy of Sciences.
[32] T. Williams,et al. Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase , 2010, Molecular biology of the cell.
[33] J. Brenman,et al. Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila , 2010, PloS one.
[34] D. Hardie. Targeting the Core of Transcription , 2010, Science.
[35] David Carling,et al. Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation , 2010, Science.
[36] N. Mizushima,et al. Autophagy in mammalian development and differentiation , 2010, Nature Cell Biology.
[37] D. Klionsky,et al. Eaten alive: a history of macroautophagy , 2010, Nature Cell Biology.
[38] J. Auwerx,et al. AMP-activated protein kinase and its downstream transcriptional pathways , 2010, Cellular and Molecular Life Sciences.
[39] B. Viollet,et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.
[40] F. Ross,et al. Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010, Cell metabolism.
[41] S. Gygi,et al. Network organization of the human autophagy system , 2010, Nature.
[42] K. Kaibuchi,et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation , 2010, Nature Cell Biology.
[43] B. Viollet,et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. , 2010, Cell metabolism.
[44] N. Mizushima,et al. The role of the Atg1/ULK1 complex in autophagy regulation. , 2010, Current opinion in cell biology.
[45] A. Prescott,et al. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion , 2010, Science Signaling.
[46] B. Viollet,et al. Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways. , 2010, Experimental cell research.
[47] J. Auwerx,et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. , 2010, Cell metabolism.
[48] Charles Schmidt. GSK/Sirtris compounds dogged by assay artifacts , 2010, Nature Biotechnology.
[49] Venkataraman Thanabal,et al. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦ , 2010, The Journal of Biological Chemistry.
[50] C. Thompson,et al. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation , 2009, Proceedings of the National Academy of Sciences.
[51] N. Oshiro,et al. Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy , 2009, Molecular and Cellular Biology.
[52] D. Hardie,et al. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP , 2009, The Biochemical journal.
[53] B. Viollet,et al. AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol , 2009, Diabetes.
[54] G. Rutter,et al. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation , 2009, Islets.
[55] S. Panda,et al. AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation , 2009, Science.
[56] S. J. Deminoff,et al. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy , 2009, Proceedings of the National Academy of Sciences.
[57] R. Shaw,et al. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression , 2009, Nature Reviews Cancer.
[58] H. Clevers,et al. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. , 2009, Physiological reviews.
[59] Gaochao Zhou,et al. AMPK: an emerging drug target for diabetes and the metabolic syndrome. , 2009, Cell metabolism.
[60] P. Puigserver,et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.
[61] A. López-Rivas,et al. TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells , 2009, The EMBO journal.
[62] M. Schwartz,et al. Regulation of LKB1/STRAD Localization and Function by E-Cadherin , 2009, Current Biology.
[63] R. Roy,et al. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival , 2009, Nature.
[64] L. Marroquin,et al. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. , 2008, Toxicology and applied pharmacology.
[65] Claudio R. Santos,et al. SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth , 2008, Cell metabolism.
[66] Maria M. Mihaylova,et al. AMPK and PPARδ Agonists Are Exercise Mimetics , 2008, Cell.
[67] K. Sakamoto,et al. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. , 2008, American journal of physiology. Endocrinology and metabolism.
[68] Zhi-mei Liu,et al. Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice. , 2008, Biochemical and biophysical research communications.
[69] A. Means,et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. , 2008, Cell metabolism.
[70] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[71] B. Kemp,et al. AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.
[72] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[73] A. Nakashima,et al. AMP-activated Protein Kinase Phosphorylates Golgi-specific Brefeldin A Resistance Factor 1 at Thr1337 to Induce Disassembly of Golgi Apparatus* , 2008, Journal of Biological Chemistry.
[74] U. Stochaj,et al. Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway. , 2007, American journal of physiology. Cell physiology.
[75] S. Gygi,et al. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.
[76] S. Gygi,et al. An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans , 2007, Current Biology.
[77] D. Hardie,et al. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.
[78] Filip Rolland,et al. A central integrator of transcription networks in plant stress and energy signalling , 2007, Nature.
[79] B. Viollet,et al. Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iϵ (CKIϵ)-dependent Degradation of Clock Protein mPer2* , 2007, Journal of Biological Chemistry.
[80] B. Spiegelman,et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.
[81] Jun Hee Lee,et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase , 2007, Nature.
[82] T. Wandless,et al. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes , 2007, Nature Medicine.
[83] P. Fisher,et al. Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. , 2007, Molecular biology of the cell.
[84] S. Okamoto,et al. Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase , 2007, Molecular and Cellular Biology.
[85] Gordon B. Mills,et al. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.
[86] P. Sengupta,et al. KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC , 2007, The EMBO journal.
[87] L. Cantley,et al. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase , 2007, Proceedings of the National Academy of Sciences.
[88] D. Hardie,et al. AMP-activated protein kinase as a drug target. , 2007, Annual review of pharmacology and toxicology.
[89] E. Inoue,et al. AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. , 2006, Biochemical and biophysical research communications.
[90] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[91] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[92] M. Caplan,et al. AMP-activated protein kinase regulates the assembly of epithelial tight junctions , 2006, Proceedings of the National Academy of Sciences.
[93] Michael D. Schneider,et al. A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.
[94] D. Vertommen,et al. New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases , 2006, Molecular and Cellular Biology.
[95] D. Hardie. Neither LKB1 nor AMPK are the direct targets of metformin. , 2006, Gastroenterology.
[96] Mengwei Zang,et al. Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice , 2006, Diabetes.
[97] D. Hardie,et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes , 2006, The Journal of experimental medicine.
[98] Kei Sakamoto,et al. LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.
[99] L. Kifle,et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.
[100] M. Febbraio,et al. Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. , 2006, American journal of physiology. Endocrinology and metabolism.
[101] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[102] A. Means,et al. The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.
[103] A. Edelman,et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.
[104] R. Heath,et al. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.
[105] E. Olson,et al. An expression screen reveals modulators of class II histone deacetylase phosphorylation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[106] B. Viollet,et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. , 2005, Diabetes.
[107] Russell G. Jones,et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.
[108] Mengwei Zang,et al. AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells* , 2004, Journal of Biological Chemistry.
[109] H. Ronne,et al. Snf1‐related protein kinase 1 is needed for growth in a normal day–night light cycle , 2004, The EMBO journal.
[110] Lewis C Cantley,et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[111] B. Lu,et al. PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila , 2004, Cell.
[112] Jérôme Boudeau,et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.
[113] Hans C Clevers,et al. Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD , 2004, Cell.
[114] David Carling,et al. Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .
[115] Jérôme Boudeau,et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.
[116] Yu Hong,et al. AMP-activated Protein Kinase Regulates HNF4α Transcriptional Activity by Inhibiting Dimer Formation and Decreasing Protein Stability* , 2003, Journal of Biological Chemistry.
[117] Daniel St Johnston,et al. A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.
[118] R. Drenan,et al. The FKBP12‐rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase , 2002, EMBO reports.
[119] E. Gulve,et al. Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations. , 2002, Biochemical and biophysical research communications.
[120] H. Yamashita,et al. Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription , 2002, The Journal of Biological Chemistry.
[121] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[122] P. Roach,et al. Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p , 2001, Molecular and Cellular Biology.
[123] K. Petersen,et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. , 2000, Diabetes.
[124] Kazuya Nagano,et al. Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex , 2000, The Journal of cell biology.
[125] D. Morton,et al. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.
[126] A. Prescott,et al. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. , 1998, The Biochemical journal.
[127] G. Drewes,et al. MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption , 1997, Cell.
[128] J. Goldstein,et al. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[129] David Carling,et al. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis , 1987, FEBS letters.
[130] E. Olson,et al. The many roles of histone deacetylases in development and physiology: implications for disease and therapy , 2009, Nature Reviews Genetics.
[131] M. Carlson,et al. SNF1/AMPK pathways in yeast. , 2008, Frontiers in bioscience : a journal and virtual library.
[132] I. Macara,et al. Regulates LKB 1 Localization by Blocking Access to Importin-, and by Association with Crm 1 and Exportin-7 , 2007 .
[133] J. Girard,et al. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. , 2005, Biochimie.
[134] D. Hardie,et al. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.
[135] A. Prescott,et al. AMP-activated protein kinase : greater AMP dependence , and preferential nuclear localization , of complexes containing the α 2 isoform , 1998 .