The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

[1]  D. St Johnston,et al.  LKB1 and AMPK maintain epithelial cell polarity under energetic stress , 2013, The Journal of cell biology.

[2]  S. Gamblin,et al.  AMP-activated protein kinase: also regulated by ADP? , 2011, Trends in biochemical sciences.

[3]  Clemens Diwoky,et al.  Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia , 2011, Science.

[4]  B. Kemp,et al.  AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase , 2011, Science.

[5]  M. Birnbaum,et al.  ADaPting to Energetic Stress , 2011, Science.

[6]  G. Shulman,et al.  Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. , 2011, Cell metabolism.

[7]  B. Faubert,et al.  Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. , 2011, Genes & development.

[8]  John B. Thomas,et al.  A Hormone-Dependent Module Regulating Energy Balance , 2011, Cell.

[9]  R. Evans,et al.  Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.

[10]  Chawnshang Chang,et al.  Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity , 2011, Diabetes.

[11]  P. Rakic,et al.  AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization , 2011, Science.

[12]  Vincent Mirouse,et al.  The LKB1/AMPK polarity pathway , 2011, FEBS letters.

[13]  Mengwei Zang,et al.  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.

[14]  B. Viollet,et al.  AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner , 2011, PloS one.

[15]  B. Viollet,et al.  AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress , 2011, Proceedings of the National Academy of Sciences.

[16]  David Carling,et al.  AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. , 2011, The Biochemical journal.

[17]  David Carling,et al.  Structure of Mammalian AMPK and its regulation by ADP , 2011, Nature.

[18]  Xiaodong Wang,et al.  Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK , 2011, Proceedings of the National Academy of Sciences.

[19]  R. Lifton,et al.  AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane*♦ , 2011, The Journal of Biological Chemistry.

[20]  M. Montminy,et al.  CREB and the CRTC co-activators: sensors for hormonal and metabolic signals , 2011, Nature Reviews Molecular Cell Biology.

[21]  G. Manning,et al.  Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB , 2011, Nature.

[22]  D. Hardie AMPK and autophagy get connected , 2011, The EMBO journal.

[23]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[24]  B. Viollet,et al.  Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.

[25]  R. Moran,et al.  Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. , 2010, Cancer research.

[26]  Joseph S. Takahashi,et al.  Circadian Integration of Metabolism and Energetics , 2010, Science.

[27]  J. Girard,et al.  Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. , 2010, The Journal of clinical investigation.

[28]  Hong-Gang Wang,et al.  The Association of AMPK with ULK1 Regulates Autophagy , 2010, PloS one.

[29]  Gerd Walz,et al.  Primary cilia regulate mTORC1 activity and cell size through Lkb1 , 2010, Nature Cell Biology.

[30]  S. Morrison,et al.  Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells , 2010, Nature.

[31]  B. Kemp,et al.  β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) , 2010, Proceedings of the National Academy of Sciences.

[32]  T. Williams,et al.  Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase , 2010, Molecular biology of the cell.

[33]  J. Brenman,et al.  Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila , 2010, PloS one.

[34]  D. Hardie Targeting the Core of Transcription , 2010, Science.

[35]  David Carling,et al.  Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation , 2010, Science.

[36]  N. Mizushima,et al.  Autophagy in mammalian development and differentiation , 2010, Nature Cell Biology.

[37]  D. Klionsky,et al.  Eaten alive: a history of macroautophagy , 2010, Nature Cell Biology.

[38]  J. Auwerx,et al.  AMP-activated protein kinase and its downstream transcriptional pathways , 2010, Cellular and Molecular Life Sciences.

[39]  B. Viollet,et al.  Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.

[40]  F. Ross,et al.  Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010, Cell metabolism.

[41]  S. Gygi,et al.  Network organization of the human autophagy system , 2010, Nature.

[42]  K. Kaibuchi,et al.  AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation , 2010, Nature Cell Biology.

[43]  B. Viollet,et al.  Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. , 2010, Cell metabolism.

[44]  N. Mizushima,et al.  The role of the Atg1/ULK1 complex in autophagy regulation. , 2010, Current opinion in cell biology.

[45]  A. Prescott,et al.  New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion , 2010, Science Signaling.

[46]  B. Viollet,et al.  Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways. , 2010, Experimental cell research.

[47]  J. Auwerx,et al.  Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. , 2010, Cell metabolism.

[48]  Charles Schmidt GSK/Sirtris compounds dogged by assay artifacts , 2010, Nature Biotechnology.

[49]  Venkataraman Thanabal,et al.  SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦ , 2010, The Journal of Biological Chemistry.

[50]  C. Thompson,et al.  The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation , 2009, Proceedings of the National Academy of Sciences.

[51]  N. Oshiro,et al.  Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy , 2009, Molecular and Cellular Biology.

[52]  D. Hardie,et al.  Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP , 2009, The Biochemical journal.

[53]  B. Viollet,et al.  AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol , 2009, Diabetes.

[54]  G. Rutter,et al.  Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation , 2009, Islets.

[55]  S. Panda,et al.  AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation , 2009, Science.

[56]  S. J. Deminoff,et al.  The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy , 2009, Proceedings of the National Academy of Sciences.

[57]  R. Shaw,et al.  The LKB1–AMPK pathway: metabolism and growth control in tumour suppression , 2009, Nature Reviews Cancer.

[58]  H. Clevers,et al.  LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. , 2009, Physiological reviews.

[59]  Gaochao Zhou,et al.  AMPK: an emerging drug target for diabetes and the metabolic syndrome. , 2009, Cell metabolism.

[60]  P. Puigserver,et al.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.

[61]  A. López-Rivas,et al.  TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells , 2009, The EMBO journal.

[62]  M. Schwartz,et al.  Regulation of LKB1/STRAD Localization and Function by E-Cadherin , 2009, Current Biology.

[63]  R. Roy,et al.  Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival , 2009, Nature.

[64]  L. Marroquin,et al.  Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. , 2008, Toxicology and applied pharmacology.

[65]  Claudio R. Santos,et al.  SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth , 2008, Cell metabolism.

[66]  Maria M. Mihaylova,et al.  AMPK and PPARδ Agonists Are Exercise Mimetics , 2008, Cell.

[67]  K. Sakamoto,et al.  Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. , 2008, American journal of physiology. Endocrinology and metabolism.

[68]  Zhi-mei Liu,et al.  Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice. , 2008, Biochemical and biophysical research communications.

[69]  A. Means,et al.  Hypothalamic CaMKK2 contributes to the regulation of energy balance. , 2008, Cell metabolism.

[70]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[71]  B. Kemp,et al.  AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.

[72]  Daniel J. Klionsky,et al.  Autophagy fights disease through cellular self-digestion , 2008, Nature.

[73]  A. Nakashima,et al.  AMP-activated Protein Kinase Phosphorylates Golgi-specific Brefeldin A Resistance Factor 1 at Thr1337 to Induce Disassembly of Golgi Apparatus* , 2008, Journal of Biological Chemistry.

[74]  U. Stochaj,et al.  Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway. , 2007, American journal of physiology. Cell physiology.

[75]  S. Gygi,et al.  The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.

[76]  S. Gygi,et al.  An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans , 2007, Current Biology.

[77]  D. Hardie,et al.  AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.

[78]  Filip Rolland,et al.  A central integrator of transcription networks in plant stress and energy signalling , 2007, Nature.

[79]  B. Viollet,et al.  Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iϵ (CKIϵ)-dependent Degradation of Clock Protein mPer2* , 2007, Journal of Biological Chemistry.

[80]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[81]  Jun Hee Lee,et al.  Energy-dependent regulation of cell structure by AMP-activated protein kinase , 2007, Nature.

[82]  T. Wandless,et al.  SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes , 2007, Nature Medicine.

[83]  P. Fisher,et al.  Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. , 2007, Molecular biology of the cell.

[84]  S. Okamoto,et al.  Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase , 2007, Molecular and Cellular Biology.

[85]  Gordon B. Mills,et al.  The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.

[86]  P. Sengupta,et al.  KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC , 2007, The EMBO journal.

[87]  L. Cantley,et al.  Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase , 2007, Proceedings of the National Academy of Sciences.

[88]  D. Hardie,et al.  AMP-activated protein kinase as a drug target. , 2007, Annual review of pharmacology and toxicology.

[89]  E. Inoue,et al.  AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. , 2006, Biochemical and biophysical research communications.

[90]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[91]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[92]  M. Caplan,et al.  AMP-activated protein kinase regulates the assembly of epithelial tight junctions , 2006, Proceedings of the National Academy of Sciences.

[93]  Michael D. Schneider,et al.  A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.

[94]  D. Vertommen,et al.  New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases , 2006, Molecular and Cellular Biology.

[95]  D. Hardie Neither LKB1 nor AMPK are the direct targets of metformin. , 2006, Gastroenterology.

[96]  Mengwei Zang,et al.  Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice , 2006, Diabetes.

[97]  D. Hardie,et al.  Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes , 2006, The Journal of experimental medicine.

[98]  Kei Sakamoto,et al.  LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.

[99]  L. Kifle,et al.  Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.

[100]  M. Febbraio,et al.  Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. , 2006, American journal of physiology. Endocrinology and metabolism.

[101]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[102]  A. Means,et al.  The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.

[103]  A. Edelman,et al.  Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.

[104]  R. Heath,et al.  Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.

[105]  E. Olson,et al.  An expression screen reveals modulators of class II histone deacetylase phosphorylation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[106]  B. Viollet,et al.  Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. , 2005, Diabetes.

[107]  Russell G. Jones,et al.  AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.

[108]  Mengwei Zang,et al.  AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells* , 2004, Journal of Biological Chemistry.

[109]  H. Ronne,et al.  Snf1‐related protein kinase 1 is needed for growth in a normal day–night light cycle , 2004, The EMBO journal.

[110]  Lewis C Cantley,et al.  The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[111]  B. Lu,et al.  PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila , 2004, Cell.

[112]  Jérôme Boudeau,et al.  LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.

[113]  Hans C Clevers,et al.  Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD , 2004, Cell.

[114]  David Carling,et al.  Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .

[115]  Jérôme Boudeau,et al.  Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.

[116]  Yu Hong,et al.  AMP-activated Protein Kinase Regulates HNF4α Transcriptional Activity by Inhibiting Dimer Formation and Decreasing Protein Stability* , 2003, Journal of Biological Chemistry.

[117]  Daniel St Johnston,et al.  A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.

[118]  R. Drenan,et al.  The FKBP12‐rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase , 2002, EMBO reports.

[119]  E. Gulve,et al.  Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations. , 2002, Biochemical and biophysical research communications.

[120]  H. Yamashita,et al.  Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription , 2002, The Journal of Biological Chemistry.

[121]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[122]  P. Roach,et al.  Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p , 2001, Molecular and Cellular Biology.

[123]  K. Petersen,et al.  Mechanism by which metformin reduces glucose production in type 2 diabetes. , 2000, Diabetes.

[124]  Kazuya Nagano,et al.  Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex , 2000, The Journal of cell biology.

[125]  D. Morton,et al.  The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.

[126]  A. Prescott,et al.  AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. , 1998, The Biochemical journal.

[127]  G. Drewes,et al.  MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption , 1997, Cell.

[128]  J. Goldstein,et al.  Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[129]  David Carling,et al.  A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis , 1987, FEBS letters.

[130]  E. Olson,et al.  The many roles of histone deacetylases in development and physiology: implications for disease and therapy , 2009, Nature Reviews Genetics.

[131]  M. Carlson,et al.  SNF1/AMPK pathways in yeast. , 2008, Frontiers in bioscience : a journal and virtual library.

[132]  I. Macara,et al.  Regulates LKB 1 Localization by Blocking Access to Importin-, and by Association with Crm 1 and Exportin-7 , 2007 .

[133]  J. Girard,et al.  Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. , 2005, Biochimie.

[134]  D. Hardie,et al.  AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.

[135]  A. Prescott,et al.  AMP-activated protein kinase : greater AMP dependence , and preferential nuclear localization , of complexes containing the α 2 isoform , 1998 .