Evaluation of the safety and efficacy of recombinant factor IX (nonacog alfa) in minimally treated and previously treated Chinese patients with haemophilia B

R. YANG,* Y . ZHAO, † X. WANG,‡ J . SUN,§ J . J IN , ¶ D. WU,** R . CHARNIGO,† † A. O ’BRIEN,†† Z. ZHONG‡‡ and P . RENDO†† *Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin; †Peking Union Medical College Hospital, Beijing; ‡Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai; §Nanfang Hospital, Southern Medical University, Guangzhou; ¶The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou; **The First Affiliated Hospital of Soochow University, Suzhou, China; ††Pfizer Inc, Collegeville, PA USA; and ‡‡Pfizer Inc, Beijing, China

[1]  R. Wu,et al.  Low dose secondary prophylaxis reduces joint bleeding in severe and moderate haemophilic children: a pilot study in China , 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

[2]  P. Monahan,et al.  Safety and efficacy of investigator‐prescribed BeneFIX® prophylaxis in children less than 6 years of age with severe haemophilia B , 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

[3]  M. Poon,et al.  Haemophilia care in China: achievements of a decade of World Federation of Hemophilia treatment centre twinning activities , 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

[4]  L. Valentino,et al.  Reformulated BeneFix®: efficacy and safety in previously treated patients with moderately severe to severe haemophilia B , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[5]  V. Blanchette,et al.  The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. , 2005, Blood.

[6]  R. Yang,et al.  Retrospective analysis of 1312 patients with haemophilia and related disorders in a single Chinese institute , 2003, Haemophilia : the official journal of the World Federation of Hemophilia.

[7]  M. Haase Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates. , 2002, Blood.

[8]  K. Hanley,et al.  The manufacturing process for recombinant factor IX. , 1998, Seminars in hematology.