Comparing P300 modulations: target-to-target interval versus infrequent nontarget-to-nontarget interval in a three-stimulus task.

This study examined temporal determinants of the P300 component of the ERP in a three-stimulus visual oddball task. Frequent standards, with equiprobable targets and infrequent nontargets, were utilized. We tested whether the infrequent nontarget-to-nontarget interval (infrequent NNI) influences P300 amplitudes and latencies analogously to the target-to-target interval (TTI). EEG was recorded from 27 participants, and response time and P300 effects of TTIs and infrequent NNIs were assessed. Increases in TTI augmented target P300 amplitudes and decreased latencies and response times. However, this modulation of P300 amplitude was weak for manipulations of infrequent NNI. P300 latencies increased initially before decreasing across infrequent NNI levels. Together, these findings support the notion that the P300 has an underlying temporal mechanism that is modulated by motivationally significant events. Theoretical implications are discussed.

[1]  J. Polich,et al.  P300 from auditory and somatosensory stimuli: probability and inter-stimulus interval. , 1991, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[2]  I. Jentzsch,et al.  Sequence-sensitive subcomponents of P300: topographical analyses and dipole source localization. , 2001, Psychophysiology.

[3]  N. Squires,et al.  The effect of stimulus sequence on the waveform of the cortical event-related potential. , 1976, Science.

[4]  C. Gonsalvez,et al.  Target-to-target interval versus probability effects on P300 in one- and two-tone tasks. , 2003, Psychophysiology.

[5]  Andrew Heathcote,et al.  Sequence effects support the conflict theory of N2 and P3 in the Go/NoGo task. , 2010, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[6]  Piotr Jaskowski,et al.  Evidence for an Integrative Role of P3b in Linking Reaction to Perception , 2005 .

[7]  J. Cohen,et al.  P300, stimulus intensity, modality, and probability. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[8]  J. Polich.  Probability and inter-stimulus interval effects on the P300 from auditory stimuli. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[9]  R. Verleger.  Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3 , 1988, Behavioral and Brain Sciences.

[10]  E Gordon,et al.  Is the target-to-target interval a critical determinant of P3 amplitude? , 1999, Psychophysiology.

[11]  J. Polich.  Updating P300: An integrative theory of P3a and P3b , 2007, Clinical Neurophysiology.

[12]  E. Donchin,et al.  Probability effects on stimulus evaluation and response processes. , 1992, Journal of experimental psychology. Human perception and performance.

[13]  J. Polich,et al.  P300 amplitude is determined by target-to-target interval. , 2002, Psychophysiology.

[14]  E. Donchin,et al.  On quantifying surprise: the variation of event-related potentials with subjective probability. , 1977, Psychophysiology.

[15]  Vince D Calhoun,et al.  fMRI in an oddball task: effects of target-to-target interval. , 2005, Psychophysiology.

[16]  H. Semlitsch,et al.  A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. , 1986, Psychophysiology.

[17]  Ray Johnson.  For Distinguished Early Career Contribution to Psychophysiology: Award Address, 1985 , 1986 .

[18]  M K Kaiser,et al.  MANOVA method for analyzing repeated measures designs: an extensive primer. , 1985, Psychological bulletin.

[19]  J. Polich,et al.  P300, probability, and interstimulus interval. , 1990, Psychophysiology.

[20]  T W Picton,et al.  Temporal and sequential probability in evoked potential studies. , 1981, Canadian journal of psychology.

[21]  Jonathan D. Cohen,et al.  An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. , 2005, Annual review of neuroscience.

[22]  E. Donchin,et al.  On the dependence of P300 latency on stimulus evaluation processes. , 1984, Psychophysiology.

[23]  E Donchin,et al.  P300 and stimulus categorization: two plus one is not so different from one plus one. , 1980, Psychophysiology.

[24]  Jonathan D. Cohen,et al.  Decision making, the P3, and the locus coeruleus-norepinephrine system. , 2005, Psychological bulletin.

[25]  R. Verleger.  On the utility of P3 latency as an index of mental chronometry. , 1997, Psychophysiology.

[26]  Evian Gordon,et al.  Numbers of preceding nontargets differentially affect responses to targets in normal volunteers and patients with schizophrenia: A study of event-related potentials , 1995, Psychiatry Research.

[27]  A. Engel,et al.  What is novel in the novelty oddball paradigm? Functional significance of the novelty P3 event-related potential as revealed by independent component analysis. , 2005, Brain research. Cognitive brain research.

[28]  C. Gonsalvez,et al.  Target-to-target interval, intensity, and P300 from an auditory single-stimulus task. , 2007, Psychophysiology.

[29]  E. Donchin.  Presidential address, 1980. Surprise!...Surprise? , 1981, Psychophysiology.

[30]  E. Donchin,et al.  Is the P300 component a manifestation of context updating? , 1988, Behavioral and Brain Sciences.

[31]  R. Johnson.  A triarchic model of P300 amplitude. , 1986, Psychophysiology.

[32]  E. Donchin,et al.  The influence of stimulus deviance and novelty on the P300 and novelty P3. , 2002, Psychophysiology.

[33]  W. Pritchard.  Psychophysiology of P300. , 1981, Psychological bulletin.

[34]  Christopher D. Wickens,et al.  The effects of stimulus sequence on event related potentials: A comparison of visual and auditory sequences , 1977 .

[35]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[36]  Emanuel Donchin,et al.  The P300 component of the event-related brain potential as an index of information processing , 1982, Biological Psychology.

[37]  H. Jasper,et al.  The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. , 1999, Electroencephalography and clinical neurophysiology. Supplement.