Incidence, predictive factors and clinical significance of development of portal vein thrombosis in cirrhosis: A prospective study

The role of portal vein thrombosis (PVT) in the natural history of cirrhosis is controversial. There are few prospective studies validating risk factors for development of PVT. We analysed the incidence, factors associated with PVT development and its influence on cirrhosis decompensations and orthotopic liver transplant (OLT)‐free survival.

[1]  D. Valla,et al.  Nonselective beta‐blockers and the risk of portal vein thrombosis in patients with cirrhosis: results of a prospective longitudinal study , 2019, Alimentary pharmacology & therapeutics.

[2]  M. Senzolo,et al.  Mortality in liver transplant recipients with portal vein thrombosis – an updated meta‐analysis , 2018, Transplant international : official journal of the European Society for Organ Transplantation.

[3]  T. Lisman,et al.  Mechanisms of enhanced thrombin‐generating capacity in patients with cirrhosis , 2018, Journal of thrombosis and haemostasis : JTH.

[4]  F. Peyvandi,et al.  Evaluation of coagulation during treatment with directly acting antivirals in patients with hepatitis C virus related cirrhosis , 2017, Liver international : official journal of the International Association for the Study of the Liver.

[5]  P. Mannucci,et al.  Changing Concepts of Cirrhotic Coagulopathy , 2017, The American Journal of Gastroenterology.

[6]  D. Christodoulou,et al.  von Willebrand factor and procoagulant imbalance predict outcome in patients with cirrhosis and thrombocytopenia. , 2016, Journal of hepatology.

[7]  P. Ambrosino,et al.  The risk of venous thromboembolism in patients with cirrhosis , 2016, Thrombosis and Haemostasis.

[8]  E. Horváth-Puhó,et al.  Survival after splanchnic vein thrombosis: A 20-year nationwide cohort study. , 2016, Thrombosis research.

[9]  A. Farcomeni,et al.  Portal vein thrombosis relevance on liver cirrhosis: Italian Venous Thrombotic Events Registry , 2016, Internal and Emergency Medicine.

[10]  G. Ioannou,et al.  Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis. , 2015, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[11]  Ashish Kumar,et al.  Review article: portal vein obstruction – epidemiology, pathogenesis, natural history, prognosis and treatment , 2015, Alimentary pharmacology & therapeutics.

[12]  S. Chevret,et al.  Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study , 2015, Hepatology.

[13]  D. Valla,et al.  The coagulation system in patients with end‐stage liver disease , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[14]  Philip Wong,et al.  Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver , 2014, Hepatology.

[15]  C. Miller,et al.  Impact of untreated portal vein thrombosis on pre and post liver transplant outcomes in cirrhosis. , 2013, Annals of hepatology.

[16]  O. Yokosuka,et al.  De novo Portal Vein Thrombosis in Virus-Related Cirrhosis: Predictive Factors and Long-Term Outcomes , 2013, The American Journal of Gastroenterology.

[17]  B. Runyon,et al.  Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012 , 2013, Hepatology.

[18]  A. Luca,et al.  Natural course of extrahepatic nonmalignant partial portal vein thrombosis in patients with cirrhosis. , 2012, Radiology.

[19]  R. Groszmann,et al.  Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis , 2011, Hepatology.

[20]  A. Cucchetti,et al.  Portal Vein Thrombosis and Liver Transplantation: Evolution During 10 Years of Experience at the University of Bologna , 2011, Annals of surgery.

[21]  S. Møller EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. , 2010, Journal of hepatology.

[22]  R. Merion,et al.  Portal vein thrombosis and liver transplant survival benefit , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[23]  A. Burroughs,et al.  Systematic review: portal vein thrombosis in cirrhosis , 2010, Alimentary pharmacology & therapeutics.

[24]  J. Marrero,et al.  Portal vein thrombosis and survival in patients with cirrhosis , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[25]  A. Gasbarrini,et al.  Thrombotic risk factors in patients with liver cirrhosis: correlation with MELD scoring system and portal vein thrombosis development. , 2009, Journal of hepatology.

[26]  Paolo Bucciarelli,et al.  High levels of factor VIII and risk of extra-hepatic portal vein obstruction. , 2009, Journal of hepatology.

[27]  A. Sanyal,et al.  Prevention and Management of Gastroesophageal Varices and Variceal Hemorrhage in Cirrhosis , 2007, The American Journal of Gastroenterology.

[28]  Ramon Planas,et al.  Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. , 2007, Gastroenterology.

[29]  J. Plevris Paper alert , 2007 .

[30]  M. Björck,et al.  Incidence and risk of venous thromboembolism in patients with verified arterial thrombosis: a population study based on 23 796 consecutive autopsies , 2006, Journal of thrombosis and haemostasis : JTH.

[31]  M. Colombo,et al.  The natural history of compensated cirrhosis due to hepatitis C virus: A 17‐year cohort study of 214 patients , 2006, Hepatology.

[32]  V. Paradis,et al.  Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation , 2005, Gut.

[33]  R. Fisher,et al.  Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death , 2004 .

[34]  M. Margaglione,et al.  Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. , 2004, Journal of hepatology.

[35]  A. Alberti,et al.  Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications , 2004, Gut.

[36]  J. Mir,et al.  Liver transplantation in patients with portal vein thrombosis , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[37]  L. Blendis,et al.  Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension , 1995, Hepatology.

[38]  G. Ferraioli,et al.  Interobserver and interquipment variability of echo‐doppler examination of the portal vein: Effect of a cooperative training program , 1995, Hepatology.

[39]  R. de Franchis Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. , 2015, Journal of hepatology.

[40]  R. de Franchis Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. , 2005, Journal of hepatology.

[41]  E. J. van der Jagt,et al.  The value of Doppler ultrasound in cirrhosis and portal hypertension. , 1999, Scandinavian journal of gastroenterology. Supplement.

[42]  L. Bolondi,et al.  Value of measurement of mean portal flow velocity by Doppler flowmetry in the diagnosis of portal hypertension. , 1992, Journal of hepatology.