Optimized radiotherapy treatment planning using the complication probability factor (CPF).

Abstract A major obstacle to effective computerized optimization of radiotherapy treatment planning has been the lack of a biologically meaningful and clinically useful objective function. Our approach employs a Complication Probability Factor (CPF) based directly on radiobiological principles and clinical data. The CPF measures the likelihood that a given dose distribution will lead to serious complications in the patient as a result of damage to healthy tissue. A computerized search can be made for a treatment plan which delivers an acceptable tumoricidal dose, yet minimizes the CPF as averaged over the total volume of healthy tissue irradiated. The program is run on a PDP 11/55‡ in conjunction with a commercial treatment planning package.∗∗

[1]  J Strackee,et al.  Pseudo optimization of radiotherapy treatment planning. , 1976, British Journal of Radiology.

[2]  K E Halnan,et al.  Optimization of X-ray Treatment Planning by Computer Judgement , 1967, Physics in medicine and biology.

[3]  C. Orton,et al.  A simplification in the use of the NSD concept in practical radiotherapy. , 1973, The British journal of radiology.

[4]  E S Sternick,et al.  A FORTRAN program for the optimization of radiotherapy treatment planning using the complication probability factor (CPF). , 1980, Computer programs in biomedicine.

[5]  A Dritschilo,et al.  The complication probability factor: a method for selection of radiation treatment plans. , 1978, The British journal of radiology.

[6]  Raymond G. Wood.  Computers in radiotherapy, physical aspects , 1974 .

[7]  S. McDonald,et al.  Optimization of external beam radiation therapy. , 1977, International journal of radiation oncology, biology, physics.

[8]  M R Sontag,et al.  Clinical application of a CT based treatment planning system. , 1978, Computerized tomography.

[9]  J. S. Orr,et al.  Optimisation of radiotherapy treatment planning. , 1972, Computer programs in biomedicine.

[10]  J. Mize.  Optimization Techniques With Fortran , 1973 .

[11]  L. Hodes.  Semiautomatic optimization of external beam radiation treatment planning. , 1974, Radiology.

[12]  C S Hope,et al.  Computer Optimization of 4 MeV Treatment Planning , 1965 .

[13]  J. Kereiakes,et al.  The method of linear programming applied to radiation treatment planning. , 1968, Radiology.

[14]  Godwin C. Ovuworie.  Introduction to Operations Research Techniques , 1978 .

[15]  M Goitein,et al.  The utility of computed tomography in radiation therapy: an estimate of outcome. , 1979, International journal of radiation oncology, biology, physics.

[16]  B. Bjärngard.  Optimization in radiation therapy. , 1977, International journal of radiation oncology, biology, physics.

[17]  W. DeGinder,et al.  Optimization of external beam radiotherapy: quantitative study of relative radiation effects and isoeffect patterns using PC-12 computer. , 1977, International journal of radiation oncology, biology, physics.

[18]  C S Hope,et al.  A computer program for optimised stationary beam treatment planning using score functions. , 1972, Computer programs in biomedicine.

[19]  A T Redpath,et al.  A set of fortran subroutines for optimizing radiotherapy plans. , 1975, Computer programs in biomedicine.

[20]  R E Cooper.  A gradient method of optimizing external-beam radiotherapy treatment plans. , 1978, Radiology.

[21]  A T Redpath,et al.  A new technique for radiotherapy planning using quadratic programming. , 1976, Physics in medicine and biology.