Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice.

[1]  H. Sousa,et al.  Celecoxib promotes degranulation of CD8(+) T cells in HPV-induced lesions of K14-HPV16 transgenic mice. , 2016, Life sciences.

[2]  Mechthild Krause,et al.  CD8+ tumour‐infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK‐ROG) , 2016, International journal of cancer.

[3]  P. Stern,et al.  Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma , 2015, British Journal of Cancer.

[4]  M. Bottai,et al.  A model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer. , 2015, European journal of cancer.

[5]  O. Taglialatela‐Scafati,et al.  Ptaquiloside, the major carcinogen of bracken fern, in the pooled raw milk of healthy sheep and goats: an underestimated, global concern of food safety. , 2015, Journal of agricultural and food chemistry.

[6]  H. Sousa,et al.  MicroRNA-21 expression and susceptibility to HPV-induced carcinogenesis - role of microenvironment in K14-HPV16 mice model. , 2015, Life sciences.

[7]  H. C. Hansen,et al.  Land management of bracken needs to account for bracken carcinogens--a case study from Britain. , 2015, Journal of environmental management.

[8]  H. Sousa,et al.  A Role for MicroRNA-155 Expression in Microenvironment Associated to HPV-Induced Carcinogenesis in K14-HPV16 Transgenic Mice , 2015, PloS one.

[9]  Tae Jin Kim,et al.  Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients , 2014, Nature Communications.

[10]  H. C. B. Hansen,et al.  The naturally occurring carcinogen ptaquiloside is present in groundwater below bracken vegetation , 2014, Environmental toxicology and chemistry.

[11]  E. Sturgis,et al.  Epidemiology of HPV-associated oropharyngeal cancer. , 2014, Oral oncology.

[12]  P. Oliveira,et al.  Ptaquiloside‐induced early‐stage urothelial lesions show increased cell proliferation and intact β‐catenin and E‐cadherin expression , 2014, Environmental toxicology.

[13]  A. Woltman,et al.  Understanding MHC Class I Presentation of Viral Antigens by Human Dendritic Cells as a Basis for Rational Design of Therapeutic Vaccines , 2014, Front. Immunol..

[14]  H. C. Hansen,et al.  Determination of ptaquiloside and pterosin B derived from bracken (Pteridium aquilinum) in cattle plasma, urine and milk. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[15]  C. Lopes,et al.  Illudane-type sesquiterpenes: Challenges and opportunities for toxicology and chemotherapy , 2014 .

[16]  R. Medeiros,et al.  Bovine papillomavirus: opening new trends for comparative pathology , 2014, Archives of Virology.

[17]  Fabricio M. Lopes,et al.  Ptaquiloside reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium. , 2013, Toxicology.

[18]  Sanda Remakus,et al.  Memory CD8⁺ T cell protection. , 2013, Advances in experimental medicine and biology.

[19]  C. Long,et al.  Food uses of ferns in China: a review , 2012 .

[20]  I. Malheiro,et al.  Multiple genotoxic activities of ptaquiloside in human lymphocytes: aneugenesis, clastogenesis and induction of sister chromatid exchange. , 2012, Mutation research.

[21]  P. Oliveira,et al.  Bracken-associated human and animal health hazards: chemical, biological and pathological evidence. , 2012, Journal of hazardous materials.

[22]  L. Nasir,et al.  Papillomavirus E5: the smallest oncoprotein with many functions , 2011, Molecular Cancer.

[23]  P. Oliveira,et al.  Ptaquiloside-induced, B-cell lymphoproliferative and early-stage urothelial lesions in mice. , 2011, Toxicon : official journal of the International Society on Toxinology.

[24]  M. Fletcher,et al.  Residue potential of norsesquiterpene glycosides in tissues of cattle fed Austral bracken (Pteridium esculentum). , 2011, Journal of agricultural and food chemistry.

[25]  J. Oliveira-Filho,et al.  A retrospective study of 586 tumours in Brazilian cattle. , 2011, Journal of comparative pathology.

[26]  S. Wacholder,et al.  Human papillomavirus testing in the prevention of cervical cancer. , 2011, Journal of the National Cancer Institute.

[27]  D. Gardner,et al.  Selenium reverses Pteridium aquilinum-induced immunotoxic effects. , 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  Diana M. Mitchell,et al.  An activation marker finds a function. , 2010, Immunity.

[29]  H. Fukumasu,et al.  Immunomodulatory effects of Pteridium aquilinum on natural killer cell activity and select aspects of the cellular immune response of mice , 2009, Journal of immunotoxicology.

[30]  M. Clementi,et al.  Human papillomavirus infections: new perspectives for prevention and treatment. , 2007, The new microbiologica.

[31]  Michael Y. Gerner,et al.  Signals required for programming effector and memory development by CD8+ T cells , 2006, Immunological reviews.

[32]  T. Carvalho,et al.  Urinary bladder lesions in bovine enzootic haematuria. , 2006, Journal of comparative pathology.

[33]  L. Coussens,et al.  De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. , 2005, Cancer cell.

[34]  R. Schreiber,et al.  The three Es of cancer immunoediting. , 2004, Annual review of immunology.

[35]  R. Koup,et al.  Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. , 2003, Journal of immunological methods.

[36]  Mark J. Smyth,et al.  Functional significance of the perforin/granzyme cell death pathway , 2002, Nature Reviews Immunology.

[37]  M. Alonso-amelot,et al.  Human carcinogenesis and bracken fern: a review of the evidence. , 2002, Current medicinal chemistry.

[38]  D. Hanahan,et al.  Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice. , 1997, Cancer research.

[39]  D. Hanahan,et al.  Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. , 1996, The American journal of pathology.

[40]  D. Hanahan,et al.  Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice , 1994, Journal of virology.

[41]  S. Syrjänen,et al.  Human papillomavirus involvement in esophageal precancerous lesions and squamous cell carcinomas as evidenced by microscopy and different DNA techniques. , 1992, Scandinavian journal of gastroenterology.

[42]  J. Slot,et al.  Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes , 1991, The Journal of experimental medicine.

[43]  M. Ojika,et al.  Studies on Pteridium aquilinum var. latiusculum, IV. Isolation of three p-hydroxystyrene glycosides and an efficient method for the isolation of ptaquiloside, an unstable bracken carcinogen. , 1985, Journal of natural products.

[44]  K. Wakamatsu,et al.  Ptaquiloside, a novel norsesquiterpene glucoside from bracken, var. , 1983 .

[45]  J. Mason,et al.  Carcinogenic Activity of Bracken , 1965, Nature.