Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies

[1]  R. Bellomo,et al.  Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis , 2021, Intensive Care Medicine.

[2]  G. Van den Berghe,et al.  Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice , 2021, Endocrinology.

[3]  C. Sprung,et al.  Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 , 2021, Intensive Care Medicine.

[4]  I. Dimopoulou,et al.  Increased Glucocorticoid Receptor Alpha Expression and Signaling in Critically Ill Coronavirus Disease 2019 Patients* , 2021, Critical care medicine.

[5]  Samuel M. Brown,et al.  Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. , 2021, JAMA.

[6]  G. Van den Berghe,et al.  The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis , 2021, Critical Care.

[7]  E. Greimel,et al.  Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation , 2020, Translational Psychiatry.

[8]  Jiqian Xu,et al.  Glucocorticoid-Induced Leucine Zipper: A Promising Marker for Monitoring and Treating Sepsis , 2020, Frontiers in Immunology.

[9]  D. Annane,et al.  Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS , 2020, Intensive Care Medicine.

[10]  G. Chrousos,et al.  General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections , 2020, Frontiers in Endocrinology.

[11]  Jesse B. Sullivan,et al.  Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis. , 2020, Chest.

[12]  S. Orfanos,et al.  Longitudinal evaluation of glucocorticoid receptor alpha/beta expression and signalling, adrenocortical function and cytokines in critically ill steroid-free patients , 2019, Molecular and Cellular Endocrinology.

[13]  G. Van den Berghe,et al.  Adrenal function and dysfunction in critically ill patients , 2019, Nature Reviews Endocrinology.

[14]  C. Riccardi,et al.  Glucocorticoid-Induced Leucine Zipper: A Novel Anti-inflammatory Molecule , 2019, Front. Pharmacol..

[15]  A. Agouridis,et al.  Adrenal Aging and Its Implications on Stress Responsiveness in Humans , 2019, Front. Endocrinol..

[16]  C. Deutschman,et al.  Cecal Ligation and Puncture Alters Glucocorticoid Receptor Expression , 2018, Critical care medicine.

[17]  B. Souweine,et al.  Hydrocortisone plus Fludrocortisone for Adults with Septic Shock , 2018, The New England journal of medicine.

[18]  R. Bellomo,et al.  Adjunctive Glucocorticoid Therapy in Patients with Septic Shock , 2018, The New England journal of medicine.

[19]  G. Van den Berghe,et al.  Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 , 2018, Intensive Care Medicine.

[20]  G. Fries,et al.  The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease , 2017, International journal of molecular sciences.

[21]  P. Marik,et al.  Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) , 2017, Intensive Care Medicine.

[22]  G. Van den Berghe,et al.  Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness. , 2017, Journal of visualized experiments : JoVE.

[23]  Thaddeus S Block,et al.  The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness , 2017, The Journal of Steroid Biochemistry and Molecular Biology.

[24]  A. Blumenthal,et al.  Glucocorticoid Sensitivity Is Highly Variable in Critically Ill Patients With Septic Shock and Is Associated With Disease Severity* , 2016, Critical care medicine.

[25]  Suzi Hong,et al.  Glucocorticoid mediated regulation of inflammation in human monocytes is associated with depressive mood and obesity , 2016, Psychoneuroendocrinology.

[26]  Shery Jacob,et al.  A simple practice guide for dose conversion between animals and human , 2016, Journal of basic and clinical pharmacy.

[27]  C. Epperson,et al.  Sex differences and stress across the lifespan , 2015, Nature Neuroscience.

[28]  K. Manolopoulos,et al.  Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT). , 2015, The Journal of clinical endocrinology and metabolism.

[29]  J. Cidlowski,et al.  Sexually dimorphic actions of glucocorticoids: beyond chromosomes and sex hormones , 2014, Annals of the New York Academy of Sciences.

[30]  J. Cidlowski,et al.  Glucocorticoid receptor signaling in health and disease. , 2013, Trends in pharmacological sciences.

[31]  Lianne Abrahams,et al.  11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. , 2013, The Journal of clinical investigation.

[32]  J. Seckl,et al.  11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. , 2013, Physiological reviews.

[33]  I. Goecke,et al.  Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay , 2013, Critical Care.

[34]  J. Briegel,et al.  Effect of heparin during extracorporeal detoxification in the severity of thrombocytopenia in patients with severe sepsis , 2012, Critical Care.

[35]  P. Garrido,et al.  Aging and stress: past hypotheses, present approaches and perspectives. , 2011, Aging and disease.

[36]  Robert H. Oakley,et al.  Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids* , 2010, The Journal of Biological Chemistry.

[37]  I. Cuthill,et al.  Reporting : The ARRIVE Guidelines for Reporting Animal Research , 2010 .

[38]  S. Lamberts,et al.  Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis , 2009, Intensive Care Medicine.

[39]  P. Marik Critical illness-related corticosteroid insufficiency. , 2009, Chest.

[40]  Brian H Cuthbertson,et al.  Hydrocortisone therapy for patients with septic shock. , 2008, The New England journal of medicine.

[41]  G. Van den Berghe,et al.  Cortisol response to critical illness: effect of intensive insulin therapy. , 2006, The Journal of clinical endocrinology and metabolism.

[42]  N. H. Steigbigel Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock , 2003, Current infectious disease reports.

[43]  T. Pritts,et al.  Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[44]  S. Lamberts,et al.  Temperature‐induced down‐regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock , 1995, Clinical endocrinology.

[45]  J. Harmon,et al.  Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines. , 1993, Endocrinology.

[46]  J L Coolens,et al.  Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. , 1987, Journal of steroid biochemistry.