MICROWAVE-ASSISTED SYNTHESIS OF SOME NOVEL BENZIMIDAZOLE COMPOUNDS CONTAINING OXADIAZOLE MOIETY

N-Heterocycles have attracted scientists’ attention due to their numerous pharmaceutical applications. Benzimidazole ring takes an important place among these heterocycles because it is found naturally in the structure of vitamin B12 and shows similarity with adenine and guanine. Also, some benzimidazole derivatives are constituent of important drugs like Imet 3393 (anti-cancer), Thiabendazole (anti-helmintic), and Astemizole (antihismaminic). Another important pharmacophore, 1, 3, 4 oxadiazole nucleus has been incorporated into some important drugs. In addition, compounds including benzimidazole and oxadiazole moiety in their structure have been obtained as antimicrobial and anti-cancer agent. 12 The structures of two benzimidazole compounds which are developed