The molecular biology of arteriviruses.

.The establishment of an arterivirus family acknowledgesthemanyuniquebiologicalandmolecularpropertiesofitsfourpresent members. On the other hand, the affiliation with thecoronavirusesrecognizesanintriguingancestralrelationshipatthelevelofgenomeorganizationandreplication.ThegenomesequencesofEAV,PRRSV,LDVandSHFVwereinstrumentalin uniting and reclassifying the arteriviruses (den Boon

[1]  J. Zimmerman,et al.  Studies of porcine reproductive and respiratory syndrome (PRRS) virus infection in avian species. , 1997, Veterinary microbiology.

[2]  E. Tabuchi,et al.  Clinical and Virological Findings on Experimental Equine Viral Arteritis in Horses , 1981 .

[3]  J. Harty,et al.  Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus , 1990, Journal of virology.

[4]  D. Brian,et al.  Recombination and Coronavirus Defective Interfering RNAs☆ , 1997, Seminars in Virology.

[5]  S. Goyal,et al.  Isolation of Swine Infertility and Respiratory Syndrome Virus (Isolate ATCC VR-2332) in North America and Experimental Reproduction of the Disease in Gnotobiotic Pigs , 1992, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[6]  A. Shelokov,et al.  Simian hemorrhagic fever. I. Clinical and epizootiologic aspects of an outbreak among quarantined monkeys. , 1968, The American journal of tropical medicine and hygiene.

[7]  E. Snijder,et al.  The 5' end of the equine arteritis virus replicase gene encodes a papainlike cysteine protease , 1992, Journal of virology.

[8]  M. Lai,et al.  The Molecular Biology of Coronaviruses , 1997, Advances in Virus Research.

[9]  J. Tratschin,et al.  An indirect ELISA for the detection of antibodies against porcine reproductive and respiratory syndrome virus using recombinant nucleocapsid protein as antigen. , 1997, Journal of virological methods.

[10]  Marian C. Horzinek,et al.  Hemagglutinin-esterase, a novel structural protein of torovirus , 1997, Journal of virology.

[11]  H. Sentsui,et al.  Studies on equine viral arteritis. I. Characterization of the virus and trial survey on antibody with vero cell cultures. , 1975, Nihon juigaku zasshi. The Japanese journal of veterinary science.

[12]  R. Hamilton,et al.  Differences among Isolates of Simian Hemorrhagic Fever (SHF) Virus , 1986, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[13]  T. Inada,et al.  Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro. , 1991, The Journal of general virology.

[14]  E. D. Chirnside,et al.  Expression cloning and antigenic analysis of the nucleocapsid protein of equine arteritis virus , 1995, Virus Research.

[15]  J. Armstrong,et al.  Coronavirus mRNA synthesis involves fusion of non-contiguous sequences. , 1983, The EMBO journal.

[16]  J. Garcia,et al.  Epitope mapping of the nucleocapsid protein of European and North American isolates of porcine reproductive and respiratory syndrome virus. , 1997, The Journal of general virology.

[17]  P. Plagemann,et al.  Pseudotype virions formed between mouse hepatitis virus and lactate dehydrogenase-elevating virus (LDV) mediate LDV replication in cells resistant to infection by LDV virions , 1995, Journal of virology.

[18]  Broen Jj,et al.  Immunoglobulin transfer from immune-reconstituted SCID mice to nursing neonates: blood distribution of antibody and association with perinatal virus protection. , 1993 .

[19]  W. Swart,et al.  Replication of lactate dehydrogenase-elevating virus in macrophages. 1. Evidence for cytocidal replication. , 1982, The Journal of general virology.

[20]  Alex Pottie.  The Propagation of Influenza from Stallions to Mares , 1888 .

[21]  T. Matsumura,et al.  Induction of immune response and protection from equine viral arteritis (EVA) by formalin inactivated-virus vaccine for EVA in horses. , 1990, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.

[22]  J. Meulenberg,et al.  Infectious Transcripts from Cloned Genome-Length cDNA of Porcine Reproductive and Respiratory Syndrome Virus , 1998, Journal of Virology.

[23]  G. Palmer,et al.  Differential glycosylation of the ectodomain of the primary envelope glycoprotein of two strains of lactate dehydrogenase-elevating virus that differ in neuropathogenicity. , 1995, Virus research.

[24]  E. D. Chirnside,et al.  Comparison of M and N gene sequences distinguishes variation amongst equine arteritis virus isolates. , 1994, The Journal of general virology.

[25]  F. Wagenaar,et al.  Comparative morphogenesis of three PRRS virus strains. , 1997, Veterinary microbiology.

[26]  A. Gorbalenya,et al.  Proteolytic Processing of the Open Reading Frame 1b-Encoded Part of Arterivirus Replicase Is Mediated by nsp4 Serine Protease and Is Essential for Virus Replication , 1999, Journal of Virology.

[27]  R. Rowland,et al.  Lactate dehydrogenase-elevating virus (LDV): subgenomic mRNAs, mRNA leader and comparison of 3'-terminal sequences of two LDV isolates , 1992, Virus Research.

[28]  P. Plagemann,et al.  The IA antigen is not the major receptor for lactate dehydrogenase-elevating virus on macrophages from CBA and BALB/c mice. , 1988, Virus research.

[29]  F. Wagenaar,et al.  Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad. , 1992, Veterinary microbiology.

[30]  G. Wensvoort,et al.  Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome (PEARS)). , 1991, The Veterinary quarterly.

[31]  Marian C. Horzinek,et al.  The genome of equine arteritis virus. , 1975, Virology.

[32]  G. St-Laurent,et al.  Expression cloning and humoral immune response to the nucleocapsid and membrane proteins of equine arteritis virus , 1997, Clinical and diagnostic laboratory immunology.

[33]  R. Rowland,et al.  Sequences of 3' end of genome and of 5' end of open reading frame 1a of lactate dehydrogenase-elevating virus and common junction motifs between 5' leader and bodies of seven subgenomic mRNAs. , 1993, The Journal of general virology.

[34]  Sharon L. Smith,et al.  Sequence of the 3′ end of the simian hemorrhagic fever virus genome , 1997, Gene.

[35]  M. Brinton,et al.  Genotypic variation among six isolates of lactate dehydrogenase-elevating virus. , 1986, The Journal of general virology.

[36]  J. Zimmerman,et al.  Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs. , 1996, Viral immunology.

[37]  E. Godeny,et al.  Analysis of simian hemorrhagic fever virus (SHFV) subgenomic RNAs, junction sequences, and 5' leader. , 1995, Virology.

[38]  M. Lai.  Recombination in large RNA viruses: Coronaviruses , 1996, Seminars in Virology.

[39]  Y. Inaba,et al.  Effect of heparin on infection of cells by porcine reproductive and respiratory syndrome virus. , 1997, American journal of veterinary research.

[40]  E. Koonin,et al.  Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus , 1993, Journal of virology.

[41]  Marian C. Horzinek,et al.  Structural proteins of equine arteritis virus. , 1976, Journal of virology.

[42]  J. H. Strauss,et al.  Evolution of RNA viruses. , 1988, Annual review of microbiology.

[43]  Marian C. Horzinek,et al.  Toroviruses: replication, evolution and comparison with other members of the coronavirus-like superfamily. , 1993, The Journal of general virology.

[44]  W. Cafruny,et al.  Immune response to lactate dehydrogenase-elevating virus: isolation of infectious virus-immunoglobulin G complexes and quantitation of specific antiviral immunoglobulin G response in wild-type and nude mice , 1982, Infection and immunity.

[45]  Bryans Jt,et al.  Isolation of a filterable agent causing arteritis of horses and abortion by mares; its differentiation from the equine abortion (influenza) virus. , 1957 .

[46]  J. Christopher-Hennings,et al.  Serum Immune Responses to the Proteins of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus , 1994, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[47]  K. Faaberg,et al.  ORF 3 of lactate dehydrogenase-elevating virus encodes a soluble, nonstructural, highly glycosylated, and antigenic protein. , 1997, Virology.

[48]  E. D. de Kluyver,et al.  Characterization of proteins encoded by ORFs 2 to 7 of Lelystad virus , 1995, Virology.

[49]  J. D. den Boon,et al.  Equine arteritis virus subgenomic mRNA synthesis: analysis of leader-body junctions and replicative-form RNAs , 1996, Journal of virology.

[50]  G. Palmer,et al.  Sequence of the genome of lactate dehydrogenase-elevating virus: heterogenicity between strains P and C. , 1995, Virology.

[51]  J. Harty,et al.  A nested set of eight RNAs is formed in macrophages infected with lactate dehydrogenase-elevating virus , 1991, Journal of virology.

[52]  M. Ackermann,et al.  Porcine reproductive and respiratory syndrome virus enters cells through a low pH-dependent endocytic pathway. , 1996, Virus research.

[53]  Mccollum Wh,et al.  Stability of viability and immunizing potency of lyophilized, modified equine arteritis live-virus vaccine. , 1981 .

[54]  F. Lilly,et al.  Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms , 1960, Science.

[55]  J. Dopazo,et al.  Phylogenetic relationships of european strains of porcine reproductive and respiratory syndrome virus (PRRSV) inferred from DNA sequences of putative ORF-5 and ORF-7 genes. , 1996, Virus research.

[56]  M. Murtaugh,et al.  Genetic variation in the PRRS virus. , 1998, Advances in experimental medicine and biology.

[57]  K. Faaberg,et al.  Detection of negative-stranded subgenomic RNAs but not of free leader in LDV-infected macrophages , 1994, Virus Research.

[58]  M. Murtaugh,et al.  Subgenomic RNA7 is transcribed with different leader-body junction sites in PRRSV (strain VR2332) infection of CL2621 cells. , 1998, Advances in experimental medicine and biology.

[59]  R. Rowland,et al.  Cytotoxic T cells are elicited during acute infection of mice with lactate dehydrogenase-elevating virus but disappear during the chronic phase of infection , 1995, Journal of virology.

[60]  C. Contag,et al.  Age-dependent poliomyelitis of mice: expression of endogenous retrovirus correlates with cytocidal replication of lactate dehydrogenase-elevating virus in motor neurons , 1989, Journal of virology.

[61]  J. Sagripanti,et al.  The cap structure of simian hemorrhagic fever virion RNA. , 1986, Virology.

[62]  J. Bryans,et al.  Temporal distribution of equine arteritis virus in respiratory mucosa, tissues and body fluids of horses infected by inhalation. , 1971, Research in veterinary science.

[63]  P. Plagemann,et al.  Structure and chemical-physical characteristics of lactate dehydrogenase-elevating virus and its RNA , 1975, Journal of virology.

[64]  M. Raamsman,et al.  The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer , 1995, Journal of virology.

[65]  P. Plagemann,et al.  Cell surface receptors for lactate dehydrogenase-elevating virus on subpopulation of macrophages. , 1985, Virus research.

[66]  S. Dea,et al.  Intracellular synthesis, processing, and transport of proteins encoded by ORFs 5 to 7 of porcine reproductive and respiratory syndrome virus. , 1996, Virology.

[67]  W. H. Mccollum,et al.  Responses of horses vaccinated with avirulent modified-live equine arteritis virus propagated in the E. Derm (NBL-6) cell line to nasal inoculation with virulent virus. , 1986, American journal of veterinary research.

[68]  J. Bryans,et al.  Isolation of a filterable agent causing arteritis of horses and abortion by mares; its differentiation from the equine abortion (influenza) virus. , 1957, The Cornell veterinarian.

[69]  P. Rossitto,et al.  A 29K envelope glycoprotein of equine arteritis virus expresses neutralization determinants recognized by murine monoclonal antibodies. , 1993, The Journal of general virology.

[70]  K. Faaberg,et al.  The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography. , 1995, Virology.

[71]  R. Hamilton,et al.  Elimination of Persistent Simian Hemorrhagic Fever (SHF) Virus Infection in Patas Monkeys , 1986, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[72]  J. Coutelier,et al.  Difference in neutralization between lactate dehydrogenase-elevating virus isolated from acutely and chronically infected mice. , 1994, The Journal of general virology.

[73]  G. Wensvoort,et al.  Experimental reproduction of porcine epidemic abortion and respiratory syndrome (mystery swine disease) by infection with Lelystad virus: Koch's postulates fulfilled. , 1991, The Veterinary quarterly.

[74]  W. Spaan,et al.  Coronavirus Replication, Transcription, and RNA Recombination , 1995 .

[75]  J. Sagripanti.  Polyadenylic acid sequences in the genomic RNA of the togavirus of simian hemorrhagic fever. , 1985, Virology.

[76]  J. D. den Boon,et al.  Comparison of the genome organization of toro- and coronaviruses: Evidence for two nonhomologous RNA recombination events during berne virus evolution , 1991, Virology.

[77]  R. Zinkernagel,et al.  Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity. , 1997, Journal of immunology.

[78]  Z. Chen,et al.  The neutralization epitope of lactate dehydrogenase-elevating virus is located on the short ectodomain of the primary envelope glycoprotein. , 1998, Virology.

[79]  D. Paton,et al.  Production, characterization and reactivity of monoclonal antibodies to porcine reproductive and respiratory syndrome virus. , 1995, The Journal of general virology.

[80]  A. Gorbalenya,et al.  Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease , 1997, Journal of virology.

[81]  J. Harty,et al.  Formalin inactivation of the lactate dehydrogenase-elevating virus reveals a major neutralizing epitope not recognized during natural infection , 1988, Journal of virology.

[82]  Marian C. Horzinek,et al.  Coronaviruses: structure and genome expression. , 1988, The Journal of general virology.

[83]  M. Voets,et al.  Mystery swine disease in The Netherlands: the isolation of Lelystad virus. , 1991, The Veterinary quarterly.

[84]  Marian C. Horzinek,et al.  Equine arteritis virus-infected cells contain six polyadenylated virus-specific RNAs , 1982, Virology.

[85]  J. Patton,et al.  Neutralization determinants of laboratory strains and field isolates of equine arteritis virus: identification of four neutralization sites in the amino-terminal ectodomain of the G(L) envelope glycoprotein. , 1997, Virology.

[86]  F. Bürki.  Eigenschaften des Virus der Equinen Arteritis , 1965 .

[87]  E. Koonin,et al.  Complete Genomic Sequence and Phylogenetic Analysis of the Lactate Dehydrogenase-Elevating Virus (LDV) , 1993, Virology.

[88]  M. Meredith.  Porcine reproductive and respiratory syndrome. , 1993 .

[89]  J. Hedges,et al.  Genetic variation in open reading frame 2 of field isolates and laboratory strains of equine arteritis virus , 1996, Virus Research.

[90]  S. Weiss,et al.  Characterization of the leader papain-like proteinase of MHV-A59: identification of a new in vitro cleavage site. , 1995, Virology.

[91]  R. Rowland,et al.  Neonatal infection of mice with lactate dehydrogenase-elevating virus results in suppression of humoral antiviral immune response but does not alter the course of viraemia or the polyclonal activation of B cells and immune complex formation. , 1994, The Journal of general virology.

[92]  A. Gorbalenya,et al.  The Arterivirus Nsp4 Protease Is the Prototype of a Novel Group of Chymotrypsin-like Enzymes, the 3C-like Serine Proteases (*) , 1996, The Journal of Biological Chemistry.

[93]  J. Zimmerman,et al.  Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis, and induces germ cell death by apoptosis , 1997, Journal of virology.

[94]  W. H. Mccollum,et al.  Vaccination for equine viral arteritis. , 1970 .

[95]  A. D. de Vries,et al.  Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus , 1995, Journal of Virological Methods.

[96]  A. Petersen,et al.  Porcine reproductive and respiratory syndrome: temperature and pH stability of Lelystad virus and its survival in tissue specimens from viraemic pigs. , 1994, Veterinary microbiology.

[97]  K. Conzelmann,et al.  Molecular characterization of porcine respiratory and reproductive syndrome virus (PRRSV), a member of the arterivirus group , 1993 .

[98]  J. Meulenberg,et al.  Posttranslational processing and identification of a neutralization domain of the GP4 protein encoded by ORF4 of Lelystad virus , 1997, Journal of virology.

[99]  J. D. den Boon,et al.  Equine Arteritis Virus Subgenomic RNA Transcription: UV Inactivation and Translation Inhibition Studies , 1995, Virology.

[100]  J. Meulenberg,et al.  Identification and characterization of a sixth structural protein of Lelystad virus: the glycoprotein GP2 encoded by ORF2 is incorporated in virus particles. , 1996, Virology.

[101]  Mccollum Wh.  Responses of horses vaccinated with avirulent modified-live equine arteritis virus propagated in the E. Derm (NBL-6) cell line to nasal inoculation with virulent virus. , 1986 .

[102]  J. Harty,et al.  Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus. , 1986, Virus research.

[103]  R. Bende,et al.  Proteins encoded by open reading frames 3 and 4 of the genome of Lelystad virus (Arteriviridae) are structural proteins of the virion , 1996, Journal of virology.

[104]  U. Balasuriya,et al.  Phylogenetic analysis of open reading frame 5 of field isolates of equine arteritis virus and identification of conserved and nonconserved regions in the GL envelope glycoprotein. , 1995, Virology.

[105]  W. Cafruny,et al.  Immunoglobulin transfer from immune-reconstituted SCID mice to nursing neonates: blood distribution of antibody and association with perinatal virus protection. , 1993, Regional immunology.

[106]  J. Zimmerman,et al.  Excretion of porcine reproductive and respiratory syndrome virus in semen after experimentally induced infection in boars. , 1994, Journal of the American Veterinary Medical Association.

[107]  Xiaotao Lu,et al.  Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59 , 1995, Journal of virology.

[108]  S. Dea,et al.  Ultrastructural characteristics and morphogenesis of porcine reproductive and respiratory syndrome virus propagated in the highly permissive MARC-145 cell clone. , 1995, Advances in experimental medicine and biology.

[109]  S. Sawicki,et al.  Coronavirus transcription: subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis , 1990, Journal of virology.

[110]  D. Baltimore,et al.  The evolution of RNA viruses , 2017 .

[111]  S. Sawicki,et al.  Coronaviruses use discontinuous extension for synthesis of subgenome-length negative strands. , 1995, Advances in experimental medicine and biology.

[112]  J. Coutelier,et al.  Neutralization and sensitization of lactate dehydrogenase-elevating virus with monoclonal antibodies. , 1988, The Journal of general virology.

[113]  W. Cafruny.  Lactate dehydrogenase-elevating virus: biology and pathogenesis. , 1989, Critical reviews in microbiology.

[114]  C. Prieto,et al.  Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis , 1996, Journal of virology.

[115]  A. Shelokov,et al.  Simian hemorrhagic fever. 3. Isolation and characterization of a viral agent. , 1968, The American journal of tropical medicine and hygiene.

[116]  I. Brierley.  Probing the mechanism of ribosomal frameshifting on viral RNAs. , 1993, Biochemical Society transactions.

[117]  R. Baric,et al.  Characterization of replicative intermediate RNA of mouse hepatitis virus: presence of leader RNA sequences on nascent chains , 1983, Journal of virology.

[118]  H. Böhm,et al.  [Equine arteritis virus: multiplication in BHK 21-cells buoyant density and electron microscopical demonstration]. , 1970, Archiv fur die gesamte Virusforschung.

[119]  A. Shelokov,et al.  Simian Hemorrhagic Fever Virus: A New Togavirus , 1975, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[120]  D. Brian,et al.  A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[121]  A. D. de Vries,et al.  Comparison of equine arteritis virus isolates using neutralizing monoclonal antibodies and identification of sequence changes in GL associated with neutralization resistance. , 1995, The Journal of general virology.

[122]  K. Conzelmann,et al.  Porcine reproductive and respiratory syndrome virus (PRRSV): monoclonal antibodies detect common epitopes on two viral proteins of European and U.S. isolates. , 1996, Veterinary microbiology.

[123]  A. D. de Vries,et al.  Identification of the Leader-Body Junctions for the Viral Subgenomic mRNAs and Organization of the Simian Hemorrhagic Fever Virus Genome: Evidence for Gene Duplication during Arterivirus Evolution , 1998, Journal of Virology.

[124]  J. Wellink,et al.  Evolution of plus-strand RNA viruses. , 1988, Intervirology.

[125]  T. Molitor,et al.  Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine. , 1997, Viral immunology.

[126]  G. Palmer,et al.  Disulfide bonds between two envelope proteins of lactate dehydrogenase-elevating virus are essential for viral infectivity , 1995, Journal of virology.

[127]  T. Inada,et al.  Ia antigens and Fc receptors of mouse peritoneal macrophages as determinants of susceptibility to lactic dehydrogenase virus. , 1985, The Journal of general virology.

[128]  H. Laude,et al.  Complete genomic sequence of the transmissible gastroenteritis virus. , 1995, Advances in experimental medicine and biology.

[129]  M. Raamsman,et al.  Monoclonal antibodies to equine arteritis virus proteins identify the GL protein as a target for virus neutralization. , 1994, The Journal of general virology.

[130]  T. Brown,et al.  Characterisation and Mutational Analysis of an ORF 1a-Encoding Proteinase Domain Responsible for Proteolytic Processing of the Infectious Bronchitis Virus 1a/1b Polyprotein , 1995, Virology.

[131]  Marian C. Horzinek,et al.  Equine arteritis virus , 1997, Theriogenology.

[132]  C. Contag,et al.  Genomic differences between strains of lactate dehydrogenase-elevating virus. , 1986, Intervirology.

[133]  J. D. den Boon,et al.  Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily , 1991, Journal of virology.

[134]  C. Contag,et al.  Protection of C58 mice from lactate dehydrogenase-elevating virus-induced motor neuron disease by non-neutralizing antiviral antibodies without interference with virus replication , 1987, Journal of Neuroimmunology.

[135]  E. Godeny,et al.  Molecular characterization of the 3' terminus of the simian hemorrhagic fever virus genome , 1995, Journal of virology.

[136]  A. Gorbalenya,et al.  Mouse Hepatitis Virus Strain A59 RNA Polymerase Gene ORF 1a: Heterogeneity among MHV Strains , 1994, Virology.

[137]  W. London.  Epizootiology, transmission and approach to prevention of fatal simian haemorrhagic fever in rhesus monkeys , 1977, Nature.

[138]  J. Harty,et al.  Extensive cytocidal replication of lactate dehydrogenase-elevating virus in cultured peritoneal macrophages from 1-2-week-old mice. , 1989, Virus research.

[139]  W. H. Mccollum,et al.  Stability of viability and immunizing potency of lyophilized, modified equine arteritis live-virus vaccine. , 1981, American journal of veterinary research.

[140]  J. Meulenberg,et al.  Subgenomic RNAs of Lelystad virus contain a conserved leader-body junction sequence. , 1993, The Journal of general virology.

[141]  Marian C. Horzinek,et al.  Intracellular equine arteritis virus (EAV)-specific RNAs contain common sequences. , 1986, Virology.

[142]  J. D. den Boon,et al.  Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases , 1995, Journal of virology.

[143]  A. Wolstenholme,et al.  Replication of lactate dehydrogenase-elevating virus in macrophages. 2. Mechanism of persistent infection in mice and cell culture. , 1982, The Journal of general virology.

[144]  J. Coutelier,et al.  The murine antibody response to lactate dehydrogenase-elevating virus. , 1986, The Journal of general virology.

[145]  P. Halbur,et al.  A nested set of six or seven subgenomic mRNAs is formed in cells infected with different isolates of porcine reproductive and respiratory syndrome virus. , 1996, The Journal of general virology.

[146]  J. D. den Boon,et al.  An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[147]  H. Varmus,et al.  Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region , 1988, Cell.

[148]  D. Cavanagh.  Nidovirales: a new order comprising Coronaviridae and Arteriviridae. , 1997, Archives of virology.

[149]  J. Christopher-Hennings,et al.  Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies , 1993, Journal of clinical microbiology.

[150]  V. Blinov,et al.  Coronavirus genome: prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis. , 1989, Nucleic acids research.

[151]  R. Rowland,et al.  Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection , 1997, Journal of virology.

[152]  J. Clark.  Transmission of Pinkeye from Apparently Healthy Stallions to Mares , 1892 .

[153]  M. Murtaugh,et al.  Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States. , 1996, The Journal of general virology.

[154]  P. Rottier,et al.  Identification of a neutralization site in the major envelope glycoprotein (GL) of equine arteritis virus. , 1995, Virology.

[155]  T. Raabe,et al.  Nucleotide Sequence of the Human Coronavirus 229E RNA Polymerase Locus , 1993, Virology.

[156]  S. Goyal,et al.  Comparison of Porcine Alveolar Macrophages and CL 2621 for the Detection of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Anti-PRRS Antibody , 1993, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[157]  P. Branton,et al.  Regulation of apoptosis by viral gene products , 1997, Journal of virology.

[158]  J. Ziebuhr,et al.  Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity , 1995, Journal of virology.

[159]  D. Brian,et al.  Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[160]  Marian C. Horzinek,et al.  The coronaviruslike superfamily. , 1993, Advances in experimental medicine and biology.

[161]  T. Brown,et al.  Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus. , 1987, The Journal of general virology.

[162]  J. Meulenberg,et al.  Lelystad Virus, the Causative Agent of Porcine Epidemic Abortion and Respiratory Syndrome (PEARS), Is Related to LDV and EAV , 1993, Virology.

[163]  J. Harty,et al.  Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses. , 1989, Virus research.

[164]  T. Inada,et al.  Comparison of the ability of lactate dehydrogenase-elevating virus and its virion RNA to infect murine leukemia virus-infected or -uninfected cell lines , 1993, Journal of virology.

[165]  A. Bøtner,et al.  Examination of virus shedding in semen from vaccinated and from previously infected boars after experimental challenge with porcine reproductive and respiratory syndrome virus. , 1997, Veterinary microbiology.

[166]  R. Baric,et al.  Function of a 5'-end genomic RNA mutation that evolves during persistent mouse hepatitis virus infection in vitro , 1995, Journal of virology.

[167]  A. Gorbalenya,et al.  Viral cysteine proteinases , 1996, Perspectives in drug discovery and design : PD3.

[168]  M. Raamsman,et al.  The two major envelope proteins of equine arteritis virus associate into disulfide-linked heterodimers , 1995, Journal of virology.

[169]  S. Dea,et al.  Monoclonal antibodies to the ORF5 product of porcine reproductive and respiratory syndrome virus define linear neutralizing determinants. , 1997, The Journal of general virology.

[170]  R. Bende,et al.  Nucleocapsid protein N of Lelystad virus: expression by recombinant baculovirus, immunological properties, and suitability for detection of serum antibodies , 1995, Clinical and diagnostic laboratory immunology.

[171]  A. Gorbalenya,et al.  Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains , 1996, Journal of virology.

[172]  E. Snijder,et al.  Proteolytic processing of the replicase ORF1a protein of equine arteritis virus , 1994, Journal of virology.

[173]  Marian C. Horzinek,et al.  All subgenomic mRNAs of equine arteritis virus contain a common leader sequence. , 1990, Nucleic acids research.

[174]  M. Kozak,et al.  An analysis of vertebrate mRNA sequences: intimations of translational control , 1991, The Journal of cell biology.

[175]  O. Wood,et al.  Electron microscopic study of tissue cultures infected with simian haemorrhagic fever virus. , 1970, The Journal of general virology.

[176]  You-Kyung Hwang,et al.  A 68-Nucleotide Sequence within the 3′ Noncoding Region of Simian Hemorrhagic Fever Virus Negative-Strand RNA Binds to Four MA104 Cell Proteins , 1998, Journal of Virology.

[177]  V. Moennig,et al.  Lactate Dehydrogenase-Elevating Virus, Equine Arteritis Virus, and Simian Hemorrhagic Fever Virus: A New Group of Positive-Strand RNA Viruses , 1992, Advances in Virus Research.

[178]  P. Rottier,et al.  Equine arteritis virus-neutralizing antibody in the horse is induced by a determinant on the large envelope glycoprotein GL. , 1995, Journal of General Virology.

[179]  G. Dougan,et al.  Temperature-sensitive mutants of equine arteritis virus , 1980 .

[180]  S. Baker,et al.  Identification of the polymerase polyprotein products p72 and p65 of the murine coronavirus MHV-JHM , 1996, Virus Research.

[181]  Marian C. Horzinek,et al.  The Genome Organization of the Nidovirales: Similarities and Differences between Arteri-, Toro-, and Coronaviruses☆ , 1997, Seminars in Virology.

[182]  E. Koonin,et al.  The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase , 1991, Virology.

[183]  S. Goyal,et al.  Characterization of Swine Infertility and Respiratory Syndrome (SIRS) Virus (Isolate ATCC VR-2332) , 1992, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[184]  A. Gorbalenya,et al.  The Arterivirus Nsp2 Protease. , 1995, The Journal of Biological Chemistry.