Improving the detection sensitivity of pH‐weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals

To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial‐temporal relationship among diffusion, perfusion, and pH deficits in acute stroke patients.

[1]  Ravinder Reddy,et al.  CEST signal at 2 ppm (CEST@2ppm) from Z‐spectral fitting correlates with creatine distribution in brain tumor , 2014, NMR in biomedicine.

[2]  Jiadi Xu,et al.  Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum , 2017, NeuroImage.

[3]  Jiadi Xu,et al.  Variable delay multi‐pulse train for fast chemical exchange saturation transfer and relayed‐nuclear overhauser enhancement MRI , 2014, Magnetic resonance in medicine.

[4]  Manabu Inoue,et al.  MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study , 2012, The Lancet Neurology.

[5]  Jinyuan Zhou,et al.  Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI , 2011, Translational Stroke Research.

[6]  Olli Gröhn,et al.  Quantitative T1ρ and Magnetization Transfer Magnetic Resonance Imaging of Acute Cerebral Ischemia in the Rat , 2002 .

[7]  W D Heiss,et al.  Ischemic Penumbra: Evidence From Functional Imaging in Man , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  G. B. Pike,et al.  Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI , 2001, Magnetic resonance in medicine.

[9]  Jean-Claude Baron,et al.  Imaging the ischaemic penumbra , 2004, Current opinion in neurology.

[10]  Peter Jezzard,et al.  Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging , 2014, Brain : a journal of neurology.

[11]  B. Quesson,et al.  Magnetization transfer imaging of rat brain under non-steady-state conditions. Contrast prediction using a binary spin-bath model and a super-lorentzian lineshape. , 1998, Journal of magnetic resonance.

[12]  Hye-Young Heo,et al.  Whole‐brain amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging in glioma patients using low‐power steady‐state pulsed chemical exchange saturation transfer (CEST) imaging at 7T , 2016, Journal of magnetic resonance imaging : JMRI.

[13]  Nirbhay N. Yadav,et al.  Chemical exchange saturation transfer (CEST): What is in a name and what isn't? , 2011, Magnetic resonance in medicine.

[14]  John C Gore,et al.  CEST imaging of fast exchanging amine pools with corrections for competing effects at 9.4 T , 2017, NMR in biomedicine.

[15]  Yrjö Hiltunen,et al.  Estimation of the Onset Time of Cerebral Ischemia Using T1&rgr; and T2 MRI in Rats , 2010, Stroke.

[16]  Jinyuan Zhou,et al.  Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging , 2008, Magnetic resonance in medicine.

[17]  Keith Muir,et al.  Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial , 2008, The Lancet Neurology.

[18]  R J Seitz,et al.  Diffusion- and perfusion-weighted MRI. The DWI/PWI mismatch region in acute stroke. , 1999, Stroke.

[19]  Tao Jin,et al.  Spin‐locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons , 2011, Magnetic resonance in medicine.

[20]  Gil Navon,et al.  Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) , 2008, Proceedings of the National Academy of Sciences.

[21]  S M Davis,et al.  Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI , 1998, Neurology.

[22]  John C Gore,et al.  A new NOE-mediated MT signal at around -1.6ppm for detecting ischemic stroke in rat brain. , 2016, Magnetic resonance imaging.

[23]  K Wüthrich,et al.  Protein hydration in aqueous solution. , 1992, Faraday discussions.

[24]  Bennett A Landman,et al.  Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments , 2009, Magnetic resonance in medicine.

[25]  Jinyuan Zhou,et al.  Detection of the Ischemic Penumbra Using pH-Weighted MRI , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  Jinyuan Zhou,et al.  Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging , 2017, Magnetic resonance in medicine.

[27]  Kai Zhang,et al.  Selecting the reference image for registration of CEST series , 2016, Journal of magnetic resonance imaging : JMRI.

[28]  Jinyuan Zhou,et al.  Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI , 2003, Nature Medicine.

[29]  R. Wu,et al.  Fast simulation and optimization of pulse-train chemical exchange saturation transfer (CEST) imaging , 2015, Physics in medicine and biology.

[30]  Kai Zhang,et al.  Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor , 2017, Magnetic resonance in medicine.

[31]  Leif Østergaard,et al.  Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI , 2014, NMR in biomedicine.

[32]  Scott Hamilton,et al.  Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study , 2006, Annals of neurology.

[33]  Daniel Paech,et al.  Downfield‐NOE‐suppressed amide‐CEST‐MRI at 7 Tesla provides a unique contrast in human glioblastoma , 2017, Magnetic resonance in medicine.

[34]  R M Henkelman,et al.  Quantitative interpretation of magnetization transfer , 1993, Magnetic resonance in medicine.

[35]  Richard A. E. Edden,et al.  Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T , 2013, NeuroImage.

[36]  H. An,et al.  Defining the Ischemic Penumbra Using Hyperacute Neuroimaging: Deriving Quantitative Ischemic Thresholds , 2012, Translational Stroke Research.

[37]  M. Kaste,et al.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. , 2008, The New England journal of medicine.

[38]  L H Schwamm,et al.  Time course of lesion development in patients with acute stroke: serial diffusion- and hemodynamic-weighted magnetic resonance imaging. , 1998, Stroke.

[39]  Michael Erb,et al.  Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla , 2003, Magnetic resonance in medicine.

[40]  B. Siesjö Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. , 1992, Journal of neurosurgery.

[41]  Dong-Hoon Lee,et al.  Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques , 2017, Magnetic resonance in medicine.

[42]  S. Morita,et al.  False-negative diffusion-weighted MRI in acute cerebellar stroke. , 2011, Auris, nasus, larynx.

[43]  Jinyuan Zhou,et al.  Three‐dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement , 2013, Journal of magnetic resonance imaging : JMRI.

[44]  Tao Jin,et al.  MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear overhauser effect at 9.4 T , 2013, Magnetic resonance in medicine.

[45]  P. V. van Zijl,et al.  Accurate Quantitation of Water-amide Proton Exchange Rates Using the Phase-Modulated CLEAN Chemical EXchange (CLEANEX-PM) Approach with a Fast-HSQC (FHSQC) Detection Scheme , 1998, Journal of biomolecular NMR.

[46]  Guoxing Lin,et al.  Chemical exchange saturation transfer effect in blood , 2014, Magnetic resonance in medicine.

[47]  P. Jezzard,et al.  Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients , 2014, NMR in biomedicine.

[48]  J. Krakauer,et al.  Pretreatment Blood–Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator , 2014, Stroke.

[49]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[50]  Jinyuan Zhou,et al.  Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[51]  Jinyuan Zhou,et al.  Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain , 2010, Magnetic resonance in medicine.

[52]  Ravinder Reddy,et al.  A technique for in vivo mapping of myocardial creatine kinase metabolism , 2014, Nature Medicine.

[53]  Jing Yuan,et al.  APT‐weighted and NOE‐weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses , 2013, Magnetic resonance in medicine.

[54]  Donald H. Lee,et al.  Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review. , 2006, Stroke.

[55]  B. Siesjö,et al.  Thresholds in cerebral ischemia - the ischemic penumbra. , 1981, Stroke.

[56]  K. Hossmann Viability thresholds and the penumbra of focal ischemia , 1994, Annals of neurology.

[57]  G. Schlaug,et al.  The ischemic penumbra: operationally defined by diffusion and perfusion MRI. , 1999, Neurology.

[58]  K. Hossmann Pathophysiological basis of translational stroke research. , 2009, Folia neuropathologica.

[59]  K. Minematsu [Intravenous thrombolytic therapy in acute ischemic stroke]. , 2000, No to shinkei = Brain and nerve.

[60]  Ravinder Reddy,et al.  Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI , 2012, NMR in biomedicine.

[61]  Susumu Mori,et al.  Mechanism of magnetization transfer during on‐resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids , 2003, Magnetic resonance in medicine.

[62]  R R Edelman,et al.  Clinical Outcome in Ischemic Stroke Predicted by Early Diffusion-Weighted and Perfusion Magnetic Resonance Imaging: A Preliminary Analysis , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[63]  J. Alger,et al.  Beyond Mismatch: Evolving Paradigms in Imaging the Ischemic Penumbra With Multimodal Magnetic Resonance Imaging , 2003, Stroke.

[64]  Jinyuan Zhou,et al.  Chemical exchange saturation transfer imaging and spectroscopy , 2006 .

[65]  Hye-Young Heo,et al.  Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semi‐solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 tesla , 2016, Magnetic resonance in medicine.

[66]  Xuna Zhao,et al.  Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T , 2011, Magnetic resonance in medicine.

[67]  Jinyuan Zhou,et al.  Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments , 2004, Magnetic resonance in medicine.

[68]  Paul A Bottomley,et al.  Chemical exchange saturation transfer (CEST) imaging with fast variably‐accelerated sensitivity encoding (vSENSE) , 2017, Magnetic resonance in medicine.

[69]  L H Schwamm,et al.  Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. , 1999, Radiology.

[70]  Hye-Young Heo,et al.  Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla , 2016, Magnetic resonance in medicine.

[71]  M. Luby,et al.  Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison , 2007, The Lancet.

[72]  Jinyuan Zhou,et al.  Simplified quantitative description of amide proton transfer (APT) imaging during acute ischemia , 2007, Magnetic resonance in medicine.

[73]  Yi Zhang,et al.  Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI , 2015, Magnetic resonance in medicine.

[74]  Tao Jin,et al.  Magnetic resonance imaging of the Amine–Proton EXchange (APEX) dependent contrast , 2012, NeuroImage.

[75]  Suk-Tak Chan,et al.  pH-sensitive MRI demarcates graded tissue acidification during acute stroke ― pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI , 2016, NeuroImage.

[76]  Adrian F Hernandez,et al.  Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. , 2013, JAMA.

[77]  R. Knab,et al.  Tissue at risk is overestimated in perfusion-weighted imaging: MR imaging in acute stroke patients without vessel recanalization. , 2005, AJNR. American journal of neuroradiology.